Abstract: A positioning method and system is proposed, which is used to select an appropriate positioning mode in order to acquire positioning server information according to actual environment and usage requirements of a mobile terminal equipment, the system includes a setting module, a reading module and a calling module. The method implements the steps of: dividing in advance a region into a plurality of subdomains, and respectively defining an identification and its corresponding positioning mode for each subdomain; when the mobile terminal equipment entering into one of the subdomains, reading the identification corresponding to the subdomain, then searching for the corresponding positioning mode according to the preset data, and acquiring the corresponding positioning service information through executing the positioning mode.