Abstract: A computer implemented method for quantifying and predicting the progression of interstitial lung disease is disclosed herein. The method comprises obtaining at least one image based on a scan of at least a part of a patient's lung, segmenting the image to obtain a lung mask defining the periphery of the lung and to identify structures within the lung mask, and applying a weighting to the identified structures based on the relative position of the structures relative to the lung periphery to obtain a weighted score. The method may then comprise quantifying the extent of interstitial lung disease, and/or predicting the progression of interstitial lung disease, based on the weighted score.

Abstract: The present disclosure provides methods and systems for nucleic acid sequencing. Such systems and methods may use a single flow cell to perform unbiased and/or biased sequencing to generate libraries of nucleic acid molecules. An aspect of the present disclosure provides a method for increasing complexity of a sample for sequencing, the method comprising: providing a first nucleic acid sample having a first degree of complexity that differs from a desired degree of complexity; providing a second nucleic acid sample having a second degree of complexity that differs from the first degree of complexity and that differs from the desired degree of complexity; pooling at least a portion of the first nucleic acid sample and at least a portion of the second nucleic acid sample, thereby generating a pooled nucleic acid sample having the desired degree of complexity; and sequencing at least a portion of the pooled nucleic acid sample.

Abstract: A computer implemented method for quantifying and predicting the progression of interstitial lung disease is disclosed herein. The method comprises obtaining at least one image based on a scan of at least a part of a patient's lung, segmenting the image to obtain a lung mask defining the periphery of the lung and to identify structures within the lung mask, and applying a weighting to the identified structures based on the relative position of the structures relative to the lung periphery to obtain a weighted score. The method may then comprise quantifying the extent of interstitial lung disease, and/or predicting the progression of interstitial lung disease, based on the weighted score.

Abstract: The present disclosure provides methods of assessing tumor status (e.g., progression, regression, recurrence, etc.) in a subject. In an aspect, a method for assessing tumor status (e.g., progression, regression, recurrence, etc.) of a subject may comprise: based on first and second WGS data of cfDNA molecules of a subject at different time points, determing (i) a first and second plurality of CNAs and (ii) a first and a second plurality of fragment lengths; processing the first and second plurality of CNAs to determine a CNA profile change; comparing the first and second plurality of fragment lengths to determine a fragment length profile change; determining a first or second tumor fraction of the subject at the first or second timepoint, based at least in part on the CNA profile change and the fragment length profile change; and detecting a tumor status of the subject based at least in part on the first or second tumor fraction.

Abstract: The present disclosure provides methods and systems for nucleic acid sequencing. Such systems and methods may use a single flow cell to perform unbiased and/or biased sequencing to generate libraries of nucleic acid molecules. An aspect of the present disclosure provides a method for increasing complexity of a sample for sequencing, the method comprising: providing a first nucleic acid sample having a first degree of complexity that differs from a desired degree of complexity; providing a second nucleic acid sample having a second degree of complexity that differs from the first degree of complexity and that differs from the desired degree of complexity; pooling at least a portion of the first nucleic acid sample and at least a portion of the second nucleic acid sample, thereby generating a pooled nucleic acid sample having the desired degree of complexity; and sequencing at least a portion of the pooled nucleic acid sample.

Abstract: A method of producing a structure having a polymer surface with a plurality of surface domains, the surface being formed by the steps of: forming a liquid composition comprising at least one surface polymer, at least one block copolymer and at least one common solvent, the at least one block copolymer having the general formulae A-B-C, wherein A is a polymer which is the same as the surface polymer or fully miscible or partially immiscible with the surface polymer; B is a polymer which is more immiscible in the surface polymer than polymer A; and C is a terminal group; and solidifying the liquid composition to form the structure having the surface with the plurality of surface domains.

Abstract: A main object of the present invention is to provide an air cathode capable of achieving both high initial discharge capacity and high capacity retention. In the present invention, the problem is solved by providing an air cathode used in a metal-air battery, comprising: an air cathode layer containing a conductive material, a particulate catalyst and a fibrous catalyst; and an air cathode current collector for collecting current of the air cathode layer, wherein the ratio of the fibrous catalyst to the total weight of the particulate catalyst and the fibrous catalyst is 10% by weight or less.

Abstract: A method of producing a structure having a polymer surface with a plurality of surface domains, the surface being formed by the steps of: forming a liquid composition comprising at least one surface polymer, at least one block copolymer and at least one common solvent, the at least one block copolymer having the general formulae A-B-C, wherein A is a polymer which is the same as the surface polymer or fully miscible or partially immiscible with the surface polymer; B is a polymer which is more immiscible in the surface polymer than polymer A; and C is a terminal group; and solidifying the liquid composition to form the structure having the surface with the plurality of surface domains.

Abstract: Alertness level is predicted on computers or sliding charts by relationship of sleep drives and wake drives, which are separately moved relative to destination time and time zone differential. Wake drives are moved with home time. Sleep drive is moved with bedtime and sleep debt relative to times and a sleep debt scale, respectively. Resulting displays predict alertness, drowsiness, wake drives in relation to sleep drives, best bedtime, sleep debt and illumination recommendations.