Abstract: The invention relates to a method for operating a vehicle brake system and to a vehicle brake system, wherein the vehicle brake system comprises at least one hydraulic vehicle brake (10), having a brake caliper (12), having a brake piston (16), having a brake piston seal (20) which is assigned to the brake caliper (12) and which acts between the brake caliper (12) and brake piston (16), having brake pads (22), and having a brake disk (24), in which method a hydraulic brake pressure acting on the brake piston (16) is built up in a manner dependent on a braking command. The brake pressure is furthermore held in a manner dependent on the braking command. If the braking command is withdrawn, the hydraulic brake pressure acting on the brake piston (16) is reduced to a hydraulic intermediate pressure, and the hydraulic intermediate pressure is held for a defined second period of time. The hydraulic brake pressure is subsequently reduced.

Abstract: In the case of a hydraulic vehicle brake, having a brake caliper (12), having a brake piston (16), having a receiving bore (14) for the brake piston (16), and having a brake piston seal (32) that acts between the brake caliper (12) and the brake piston (16), the brake piston seal (32) is designed as a composite part, with a composite of a base component (34) and a reinforcement insert (36). The reinforcement insert (36) provides the brake piston seal (32) with a degree of elasticity in an axial direction, whereby, after the brake piston (16) has been displaced in the direction of brake pads (22), the brake piston seal (32) displaces the brake piston (16) in the opposite direction.

Abstract: The present invention provides antibodies and antibody-drug conjugates that bind to the extra domain B splice variant of fibronectin 1 and methods for preparing and using the same.

Abstract: The present invention provides antibodies and antibody-drug conjugates that bind to the extra domain B splice variant of fibronectin 1 and methods for preparing and using the same.

Abstract: The present invention provides antibodies and antibody-drug conjugates that bind to the extra domain B splice variant of fibronectin 1 and methods for preparing and using the same.

Abstract: Methods are provided for detecting 5T4-positive circulating tumor cells in a mammalian subject. Methods of diagnosing 5T4-positive cancer in a mammalian subject are provided. The methods of detection or diagnosis indicate the presence of 5T4-positive metastatic cancer or early stage 5T4-positive cancer.

Abstract: Disclosed are anti-5T4 antibody drug conjugates and methods for preparing and using the same.

Abstract: In one aspect, identification and communication systems are described herein. An identification and communication system described herein, in some embodiments, comprises one or more query units and one or more response units, wherein at least one response unit comprises one or more detectors comprising one or more optical fibers operable to direct one or more signals received from at least one query unit to the one or more detectors. In some embodiments, at least one optical fiber is operable to receive a signal from at least one query unit through the side of the optical fiber. In some embodiments, at least one optical fiber comprises a fluorescent plastic fiber (FPF). In some embodiments, at least one optical fiber is disposed in a textile.

Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.

Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.

Abstract: In one aspect, identification and communication systems are described herein. In some embodiments, an identification and communication system comprises one or more query units and one or more response units, wherein at least one query unit comprises a query beam source comprising a light emitting diode (LED) operable to emit a query beam. In some embodiments, the query beam is substantially collimated. In some embodiments, an identification and communication system comprises one or more query units and one or more response units, wherein at least one query unit comprises a first query beam source operable to emit a first component beam and a second query beam source operable to emit a second component beam. In some embodiments, the first query beam source comprises an LED and the second query beam source comprises a laser. In some embodiments, the first component beam and the second component beam are substantially concentric.

Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.

Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.

Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.

Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.

Abstract: In some embodiments, an identification and communication system described herein comprises one or more query units and one or more response units, wherein at least one query unit comprises a query beam source operable to emit a query beam and at least one response unit comprises at least one detector comprising an application specific integrated circuit (ASIC) comprising an amplifier operable to amplify the query beam. In some embodiments, a system comprises one or more query units and one or more response units, wherein at least one response unit comprises at least one detector capable of detecting incident radiation having a power of about 100 pW or less. In some embodiments, a system comprises at least one component of a response unit disposed in a first housing mounted to a weapon and at least one component of a query unit disposed in a second housing mounted to the weapon.

Abstract: In one aspect, identification and communication systems are described herein. In some embodiments, an identification and communication system comprises one or more query units and one or more response units, wherein at least one query unit is a handheld device. In some embodiments, the handheld device does not comprise a weapon and is not mounted on a weapon. In some embodiments, the handheld device comprises a flashlight. In some embodiments, the handheld device comprises a stylus. In some embodiments, the handheld device comprises a smart device in communication with the stylus. In some embodiments, the handheld device comprises a display screen. In some embodiments, the handheld device comprises a query controller and the display screen is operable to display data provided by the query controller.

Abstract: Methods are provided for detecting 5T4-positive circulating tumor cells in a mammalian subject. Methods of diagnosing 5T4-positive cancer in a mammalian subject are provided. The methods of detection or diagnosis indicate the presence of 5T4-positive metastatic cancer or early stage 5T4-positive cancer.

Abstract: Disclosed are anti-5T4 antibody drug conjugates and methods for preparing and using the same.

Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.