Patents by Inventor Peter Ghazal
Peter Ghazal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10851415Abstract: Sepsis remains a leading cause of morbidity and mortality in neonates worldwide. There is also clinically a low threshold for suspicion of infection in neonates, in particular as presentation varies greatly from very subtle to catastrophic collapse. The lack of reliably sensitive tests and the potential life-threatening consequences of delayed treatment of infection results in the widespread use of empirical antibiotics exposing many infants without infection to broad-spectrum antibiotics. The present invention provides a series of patient-invariant biomarkers for screening neonates and other subjects for infection that predicts bacterial infection with high accuracy; and is further shown to have predictive value in identifying infection in suspected cases with blood-culture negative tests.Type: GrantFiled: April 7, 2015Date of Patent: December 1, 2020Assignee: University College Cardiff Consultants LimitedInventors: Peter Ghazal, Paul Dickinson, Thorsten Forster, Claire Smith, Ben Stenson, Mizan Khondoker
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Publication number: 20170022568Abstract: Sepsis remains a leading cause of morbidity and mortality in neonates worldwide. There is also clinically a low threshold for suspicion of infection in neonates, in particular as presentation varies greatly from very subtle to catastrophic collapse. The lack of reliably sensitive tests and the potential life-threatening consequences of delayed treatment of infection results in the widespread use of empirical antibiotics exposing many infants without infection to broad-spectrum antibiotics. The present invention provides a series of patient-invariant biomarkers for screening neonates and other subjects for infection that predicts bacterial infection with high accuracy; and is further shown to have predictive value in identifying infection in suspected cases with blood-culture negative tests.Type: ApplicationFiled: April 7, 2015Publication date: January 26, 2017Inventors: Peter GHAZAL, Paul DICKINSON, Thorsten FORSTER, Claire SMITH, Ben STENSON, Mizan KHONDOKER
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Patent number: 8790595Abstract: Non-rigid tape apparatus and fabrication methods for microfluidic processing applications such as gel electrophoresis are provided, where microfluidic processing is performed on selected areas. Parts of the tape are formed by high pressure plastic film forming. Membranes and other structures are self sealing during and after penetration by pipettes and electrical probes. Rigid exoskeleton elements protect the non-rigid parts during processing and facilitate transport of the tape.Type: GrantFiled: February 7, 2012Date of Patent: July 29, 2014Assignee: Agilent Technologies, Inc.Inventors: Stuart Polwart, Joel Fearnley, Douglas Roy, Peter Ghazal
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Patent number: 8748355Abstract: The present invention relates to methods of detecting specific cell surface antigens present in a sample of cells being tested and in particular blood group antigens, which methods do not employ the addition of extrinsic labels to detect said cell surface antigens. Typically detection is carried out using an intrinsic fluorescence capability of the cells being tested.Type: GrantFiled: March 23, 2006Date of Patent: June 10, 2014Assignee: University Court of the University of EdinburghInventors: Colin Campbell, Peter Ghazal, Juraj Petrik, Janine Scott Robb
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Publication number: 20120285829Abstract: Provided is a method for detecting an analyte, which method comprises: a) applying an alternating voltage to the analyte, wherein the alternating voltage comprises a plurality of superimposed frequencies sufficient to distinguish the presence of the analyte by electrochemical impedance spectrometry (EIS); and b) determining the identity and/or quantity of the analyte from EIS data.Type: ApplicationFiled: December 7, 2010Publication date: November 15, 2012Applicant: ITI SCOTLAND LIMITEDInventors: Andrew Mount, Mizanur Khondoker, Ilenia Ciani, Till Bachmann, Peter Ghazal
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Publication number: 20120195809Abstract: Non-rigid tape apparatus and fabrication methods for microfluidic processing applications such as gel electrophoresis are provided, where microfluidic processing is performed on selected areas. Parts of the tape are formed by high pressure plastic film forming. Membranes and other structures are self sealing during and after penetration by pipettes and electrical probes. Rigid exoskeleton elements protect the non-rigid parts during processing and facilitate transport of the tape.Type: ApplicationFiled: February 7, 2012Publication date: August 2, 2012Applicant: AGILENT TECHNOLOGIES, INC.Inventors: Stuart Polwart, Joel Fearnley, Douglas Roy, Peter Ghazal
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Patent number: 8124029Abstract: Non-rigid tape apparatus and fabrication methods for microfluidic processing applications such as gel electrophoresis are provided, where microfluidic processing is performed on selected areas. Parts of the tape are formed by high pressure plastic film forming. Membranes and other structures are self sealing during and after penetration by pipettes and electrical probes. Rigid exoskeleton elements protect the non-rigid parts during processing and facilitate transport of the tape.Type: GrantFiled: November 27, 2002Date of Patent: February 28, 2012Assignee: LAB901 LimitedInventors: Stuart Polwart, Joel Fearnley, Douglas Roy, Peter Ghazal
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Publication number: 20100203516Abstract: Provided is a method for detecting an analyte, wherein the analyte is labelled with one or more labels relatable to the analyte, which method comprises: a) performing an optical detection method on the labelled analyte to obtain optical data from the one or more labels; b) performing an electrical detection method on the labelled analyte to obtain electrical data from the one or more labels; and c) determining the identity and/or quantity of the analyte from both the optical and electrical data.Type: ApplicationFiled: January 25, 2008Publication date: August 12, 2010Applicant: ITI SCOTLAND LIMITEDInventors: Colin Campbell, Peter Ghazal, John Beattie, Andrew Mount, Till Bachmann
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Publication number: 20090022628Abstract: Non-rigid tape apparatus and fabrication methods for microfluidic processing applications such as gel electrophoresis are provided, where microfluidic processing is performed on selected areas. Parts of the tape are formed by high pressure plastic film forming. Membranes and other structures are self sealing during and after penetration by pipettes and electrical probes. Rigid exoskeleton elements protect the non-rigid parts during processing and facilitate transport of the tape.Type: ApplicationFiled: September 30, 2008Publication date: January 22, 2009Inventors: Stuart Polwart, Joel Fearnley, Douglas Roy, Peter Ghazal
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Publication number: 20080318798Abstract: The present invention relates to methods of detecting specific cell surface antigens present in a sample of cells being tested and in particular blood group antigens, which methods do not employ the addition of extrinsic labels to detect said cell surface antigens. Typically detection is carried out using an intrinsic fluorescence capability of the cells being tested.Type: ApplicationFiled: March 23, 2006Publication date: December 25, 2008Inventors: Colin Campbell, Peter Ghazal, Juraj Petrik, Janine Scott Robb
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Publication number: 20070190656Abstract: The present invention provides a macromolecular switch (51) suitable for use in a data acquisition and/or processing device. The switch comprises a macromolecular structure (10) having an ion binding site (14), and is flippable between a plurality of discretely different conformations corresponding to different ion binding conditions at the ion binding site (14). The macromolecular structure (10) is provided with at least one electrochemical input device (43) for applying such different ion binding conditions to the ion binding site (14) in response to corresponding external input signals. The invention also provides a method for data acquisition and/or processing, using a macromolecular structure switch of the invention.Type: ApplicationFiled: May 4, 2004Publication date: August 16, 2007Inventors: Jason Crain, Anthony Walton, Peter Ghazal, Andrew Mount, John Beattie, Colin Campbell, Jonathan Terry, Stuart Evans
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Publication number: 20050089449Abstract: Non-rigid tape apparatus and fabrication methods for microfluidic processing applications such as gel electrophoresis are provided, where microfluidic processing is performed on selected areas. Parts of the tape are formed by high pressure plastic film forming. Membranes and other structures are self sealing during and after penetration by pipettes and electrical probes. Rigid exoskeleton elements protect the non-rigid parts during processing and facilitate transport of the tape.Type: ApplicationFiled: November 27, 2002Publication date: April 28, 2005Applicant: Lab 901 LtdInventors: Stuart Polwart, Joel Fearnley, Douglas Roy, Peter Ghazal
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Publication number: 20050079104Abstract: Non-rigid tape apparatus and fabrication methods for microfluidic processing applications such as gel electrophoresis are provided, where microfluidic processing is performed on selected areas. Parts of the tape are formed by high pressure plastic film forming. Membranes and other structures are self sealing during and after penetration by pipettes and electrical probes. Rigid exoskeleton elements protect the non-rigid parts during processing and facilitate transport of the tape.Type: ApplicationFiled: November 27, 2002Publication date: April 14, 2005Inventors: Stuart Polwart, Joel Fearnley, Douglas Roy, Peter Ghazal
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Patent number: 6692954Abstract: The present invention relates to a recombinant DNA construct comprising a YAC vector and at least a portion of the HCMV genome. The vector is useful as a basic research tool with which to study CMV biology, or as a vaccine with which to immunize a mammalian host against infection by CMV.Type: GrantFiled: November 3, 2000Date of Patent: February 17, 2004Assignee: The Scripps Research InstituteInventors: Peter Ghazal, Huang Huang