Abstract: A method for intraoperative planning and facilitating a revision arthroplasty procedure includes displaying a virtual model of a bone, capturing positions of a tracked probe as the tracked probe contacts points at a perimeter of a primary implant component coupled to the bone, generating a virtual representation of an interface between the primary implant component and the virtual model of the bone using the positions of the tracked probe, planning a bone resection using the virtual representation of the interface, and guiding execution of the bone resection.

Abstract: Using a graphical user interface (GUI), a user is guided to generate a logical graph that represents how real data is generated in a situation. The situation is simulated using an artificial intelligence (AI) model a number of times by having the AI model choose paths through the logical graph to generate synthetic data that is representative of the real data. The AI model may also use a reward table that the user is guided to generate via the GUI to execute the simulation, wherein the reward table incentivizes certain paths of the logical graph, and agents of the AI model are trained using the values of this reward table. This synthetic data generated via the AI model can be used for training other AI models.

Abstract: Provided herein are MAPT RNAi agents and compositions comprising a MAPT RNAi agent. Also provided herein are methods of using the MAPT RNAi agents or compositions comprising a MAPT RNAi agent for reducing MAPT expression and/or treating tauopathy in a subject.

Abstract: In equities trading, users typically develop trading strategies designed to achieve profitable returns. The trading strategies may include rules surrounding how to respond to particular market conditions. However, when a wide variety of conflicting market scenarios arise, users are often confused and unsure of how to untangle all the conflicting market conditions and struggle with making a final trading decision. The disclosed trade execution engine uses a switching matrix model to separate the different market conditions and reacts to the different market states based on intelligent execution driving signals.

Abstract: Methods and systems are described herein for determining auxiliary parameters within datasets, the auxiliary parameters being used to segregate the datasets such that anomaly detection may be performed on the segregated datasets. Based on anomaly detection, alert conditions may then be identified. In particular, a system may, using a machine learning model, determine for a particular target feature (e.g., a parameter being monitored) one or more auxiliary features (other parameters) that effect the values of that parameter and transmit the target feature and the auxiliary features in a message to a monitoring system indicating which features to monitor. The collected data may then be received by the system and transformed into a timeseries dataset, which may then be used to detect anomalies within the data and thereby identify any anomalous points.

Abstract: A computing system receives historical match data associated with a plurality of tennis players. The computing system generates player rankings. The player rankings include a player ranking for each tennis player of the plurality of tennis players based on the historical match data. The computing system receives information associated with a tennis tournament. The information includes a subset of tennis players in the tournament and a seeding of each tennis player in the subset of tennis players. The computing system generates initial predictions based on the information associated with the tournament and the player rankings. The computing system identifies a trigger event that causes an update to the initial predictions. Responsive to identifying the trigger event, the computing system generates an updated predictions based on in-match data. The in-match data includes a change to a score in a match of the tournament. The computing system outputs the updated predictions.

Abstract: Apparatus and methods for monitoring and processing wellbore data are disclosed. An integrated digital ecosystem comprises an applied fluid optimization specialist and one or more sensors communicatively coupled to the applied fluid optimization specialist. The applied fluid optimization specialist receives data relating to performance of subterranean operations from the one or more sensors and interprets the data received. The applied fluid optimization specialist then regulates the performance of subterranean operations based on the interpretation of the data received.

Abstract: Apparatus and methods for monitoring and processing wellbore data are disclosed. An integrated digital ecosystem comprises an applied fluid optimization specialist and one or more sensors communicatively coupled to the applied fluid optimization specialist. The applied fluid optimization specialist receives data relating to performance of subterranean operations from the one or more sensors and interprets the data received. The applied fluid optimization specialist then regulates the performance of subterranean operations based on the interpretation of the data received.

Abstract: An integrated digital ecosystem comprises an applied fluid optimization specialist and one or more sensors communicatively coupled to the applied fluid optimization specialist. The applied fluid optimization specialist receives data relating to performance of subterranean operations from the one or more sensors and interprets the data received. The applied fluid optimization specialist then regulates the performance of subterranean operations based on the interpretation of the data received.

Abstract: System, methods and devices for analyzing drilling fluids are presented herein. A fluid analysis system for determining at least one characteristic of a drilling fluid is disclosed. The system includes a pump and two reversible fluid ports each configured, when in a first state, to intake drilling fluid into the fluid analysis system and, when in a second state, to expel drilling fluid from the fluid analysis system. A valve fluidly couples the reversible fluid ports to the pump. The valve controls the respective states of the reversible fluid ports. At least one measurement module is fluidly coupled to the pump to receive drilling fluid therefrom. The at least one measurement module is configured to determine at least one characteristic of the drilling fluid. Filters can be fluidly coupled with each of the reversible fluid ports. The filters prevent solids of a predetermined size from entering the fluid analysis system.

Abstract: Apparatus and methods for monitoring and processing wellbore data are disclosed. An integrated digital ecosystem comprises an applied fluid optimization specialist and one or more sensors communicatively coupled to the applied fluid optimization specialist. The applied fluid optimization specialist receives data relating to performance of subterranean operations from the one or more sensors and interprets the data received. The applied fluid optimization specialist then regulates the performance of subterranean operations based on the interpretation of the data received.

Abstract: System, methods and devices for analyzing drilling fluids are presented herein. A fluid analysis system for determining at least one characteristic of a drilling fluid is disclosed. The system includes a pump and two reversible fluid ports each configured, when in a first state, to intake drilling fluid into the fluid analysis system and, when in a second state, to expel drilling fluid from the fluid analysis system. A valve fluidly couples the reversible fluid ports to the pump. The valve controls the respective states of the reversible fluid ports. At least one measurement module is fluidly coupled to the pump to receive drilling fluid therefrom. The at least one measurement module is configured to determine at least one characteristic of the drilling fluid. Filters can be fluidly coupled with each of the reversible fluid ports. The filters prevent solids of a predetermined size from entering the fluid analysis system.

Abstract: A device for receiving and dispensing a coatable material such as adhesive, glue, cosmetics and the like. A sleeve-shaped receiving element has a piston-shaped element carrying the coatable material that is displaceable in longitudinal direction by a screw spindle operated by an external rotary grip at the base of the receiving element. The underside of the piston-shaped element is formed to complement the inwardly protruding shape of the sleeve base or grip element, such that there is virtually no free space in which air can collect between the piston-shaped element and the sleeve base when the piston element is fully retracted in the receiving element. Thus the device avoids undesired bubble formation during the filling process, and undesired material break off during use can be largely excluded.

Abstract: A device for receiving and dispensing a coatable material comprises a sleeve-shaped receiving element in which is arranged a piston-shaped element displaceable in longitudinal direction and provided with an internal thread, the element carrying the coatable material and being displaceable by an externally operable socket-shaped rotary grip, wherein the rotary grip comprises a screw spindle co-operable with the internal thread of the piston-shaped element, the device being so improved that detaching of the coating material from the piston-shaped element is reliably avoided without impairing the sealing function.

Abstract: A device for receiving and dispensing a coatable material such as adhesive, glue, cosmetics and the like. A sleeve-shaped receiving element has a piston-shaped element carrying the coatable material that is displaceable in longitudinal direction by a screw spindle operated by an external rotary grip at the base of the receiving element. The underside of the piston-shaped element is formed to complement the inwardly protruding shape of the sleeve base or grip element, such that there is virtually no free space in which air can collect between the piston-shaped element and the sleeve base when the piston element is fully retracted in the receiving element. Thus the device avoids undesired bubble formation during the filling process, and undesired material break off during use can be largely excluded.

Abstract: A device for receiving and dispensing a coatable material comprises a sleeve-shaped receiving element in which is arranged a piston-shaped element displaceable in longitudinal direction and provided with an internal thread, the element carrying the coatable material and being displaceable by an externally operable socket-shaped rotary grip, wherein the rotary grip comprises a screw spindle co-operable with the internal thread of the piston-shaped element, the device being so improved that detaching of the coating material from the piston-shaped element is reliably avoided without impairing the sealing function.