Abstract: Provided herein are combination therapies comprising an epoxytigliane compound (for example, tigilanol tiglate) and either irradiation or a chemotherapeutic agent that is i) a chemotherapeutic agent that damages DNA (for example, cisplatin), or ii) a chemotherapeutic agent that inhibits tumour-associated host-derived cells that support the growth and/or invasion of tumour cells (for example, 5-fluoruracil, or doxorubicin). Pharmaceutical compositions and kits containing epoxytigliane compounds and the chemotherapeutic agents are also provided.

Abstract: The present invention relates to methods of treating tumours comprising the localised administration, for example, intratumourally or topically, of an epoxytiglienone compound (as a monotherapy) to cancerous tumours to generate a systemic anticancer abscopal (anenestic) and/or bystander effect.

Abstract: Systems, methods, and computer-readable media are provided for processing and settling financial transactions. An example method comprises receiving a transaction from an originator. The transaction comprises information associated with an identification of an initiating user or the account. The method comprises determining the actual account number, transmitting a financial services transaction request comprising the actual account number to a financial institution, receiving a response, and transmitting a response back to the originator. Another method comprises receiving, from a user device, a request to associate a financial account with a user account. The method comprises generating and sending an association message to a payment network and receiving a key associated with the financial account for use in initiating financial transactions. Another method comprises utilizing such a key to generate and process a transaction request. Other systems, methods, and media are also provided.

Abstract: Systems, methods, and computer-readable media are provided for processing and settling financial transactions. An example method comprises receiving a transaction from an originator. The transaction comprises information associated with an identification of an initiating user or the account. The method comprises determining the actual account number, transmitting a financial services transaction request comprising the actual account number to a financial institution, receiving a response, and transmitting a response back to the originator. Another method comprises receiving, from a user device, a request to associate a financial account with a user account. The method comprises generating and sending an association message to a payment network and receiving a key associated with the financial account for use in initiating financial transactions. Another method comprises utilizing such a key to generate and process a transaction request. Other systems, methods, and media are also provided.

Abstract: Systems and methods are provided for processing cardless financial transactions at transaction devices such as Automated Teller Machines. An example method comprises receiving a transaction request including at least one transaction parameter and receiving a substitute value representing an account for processing the transaction request. The substitute value is distinct from an account number associated with the account. The method further comprises sending the at least one transaction parameter and the substitute value to a payment network associated with the substitute value and completing the transaction request. A second method comprises receiving a transaction request with at least one transaction parameter and a substitute value. The second method further comprises determining account credentials associated with the substitute value using the account credentials.

Abstract: Systems, methods, and computer-readable media are provided for processing and settling financial transactions. An example method comprises receiving a transaction from an originator. The transaction comprises information associated with an identification of an initiating user or the account. The method comprises determining the actual account number, transmitting a financial services transaction request comprising the actual account number to a financial institution, receiving a response, and transmitting a response back to the originator. Another method comprises receiving, from a user device, a request to associate a financial account with a user account. The method comprises generating and sending an association message to a payment network and receiving a key associated with the financial account for use in initiating financial transactions. Another method comprises utilizing such a key to generate and process a transaction request. Other systems, methods, and media are also provided.

Abstract: Systems and methods are provided for processing cardless financial transactions at transaction devices such as Automated Teller Machines. An example method comprises receiving a transaction request including at least one transaction parameter and receiving a substitute value representing an account for processing the transaction request. The substitute value is distinct from an account number associated with the account. The method further comprises sending the at least one transaction parameter and the substitute value to a payment network associated with the substitute value and completing the transaction request. A second method comprises receiving a transaction request with at least one transaction parameter and a substitute value. The second method further comprises determining account credentials associated with the substitute value using the account credentials.

Abstract: A method of making a fibrous sheet includes providing a first furnish including a primary pulp having papermaking fibers, the papermaking fibers (i) having a weight-weighted average fiber length between about two and seven tenths millimeters and about three millimeters, (ii) a coarseness of about sixteen milligrams per one hundred meters or lower, and (iii) being at least eighty percent of the papermaking fibers of the first furnish, forming a nascent web having at least two layers, one of the at least two layers being (i) a surface layer of the nascent web and (ii) formed from the first furnish, dewatering the nascent web to form a dewatered web, applying the surface layer of the dewatered web to the outer surface of a Yankee drum of a Yankee dryer, and drying the dewatered web with the Yankee dryer to form a fibrous sheet.

Abstract: The current disclosure relates to vapor phase methods of depositing a metal or a semimetal-comprising materials on a substrate. In the methods, various metal or semimetal precursors may be used together with reactants that may generate hydrogen radical or amino radical to react with the metal or semimetal precursor to deposit the metal or semimetal-comprising material on the substrate. The disclosure further relates to materials and structures deposited by the disclosed methods, as well as deposition assemblies.

Abstract: A fluid conduit disinfector includes a conduit with a fluid disinfection channel defined by inner side surface of the conduit, wherein the inner side surface of the conduit is reflective with a germicidal ultraviolet (GUV) light reflectance R of 50%-99%; a GUV light source for emitting GUV light into the fluid disinfection channel; a fan for forcing a fluid to be disinfected to flow through the fluid disinfection channel, and a filter for filtering particles from the fluid. The fluid disinfection channel may include a first section, a second section and a third section, wherein the first section has a cylindrical shape with a first diameter, the third section has a cylindrical shape with a third diameter larger than the first diameter, the second section has a truncated conical shape and is positioned between the first section and the third section.

Abstract: An escape system comprises a slide for facilitating evacuation of from a structure to water, wherein the slide comprises at least one helical inflatable path. The or each helical inflatable path may be configured to extend generally vertically between the structure and the water. The slide may comprise a plurality of helical inflatable paths. The slide may comprise spacing means for controlling the pitch between helix turns of the or each of the helical inflatable paths. A bowsing arrangement for the slide is also disclosed.

Abstract: Systems and methods for real-time account access, allowing access to accounts (such as deposit, credit, or debit accounts) through network processing infrastructures such as Electronic Funds Transfer (EFT). In some embodiments, consumers and/or merchants are able to effect transaction requests against accounts, using a pseudo-Identifier or other identifier, and without the need to provide an account number or card number. In other embodiments, payment networks are able to route and process transaction requests against accounts, without having a card number or account number. In other embodiments, account processing systems are able to determine an appropriate account based on transaction requests that do not contain card numbers or account numbers.

Abstract: Systems, methods, and computer-readable media are provided for processing and settling financial transactions. An example method comprises receiving a transaction from an originator. The transaction comprises information associated with an identification of an initiating user or the account. The method comprises determining the actual account number, transmitting a financial services transaction request comprising the actual account number to a financial institution, receiving a response, and transmitting a response back to the originator. Another method comprises receiving, from a user device, a request to associate a financial account with a user account. The method comprises generating and sending an association message to a payment network and receiving a key associated with the financial account for use in initiating financial transactions. Another method comprises utilizing such a key to generate and process a transaction request. Other systems, methods, and media are also provided.

Abstract: Systems and methods for real-time account access, allowing access to accounts (such as deposit, credit, or debit accounts) through network processing infrastructures such as Electronic Funds Transfer (EFT). In some embodiments, consumers and/or merchants are able to effect transaction requests against accounts, using a pseudo-identifier or other identifier, and without the need to provide an account number or card number. In other embodiments, payment networks are able to route and process transaction requests against accounts, without having a card number or account number. In other embodiments, account processing systems are able to determine an appropriate account based on transaction requests that do not contain card numbers or account numbers.

Abstract: Systems and methods for real-time account access, allowing access to accounts (such as deposit, credit, or debit accounts) through network processing infrastructures such as Electronic Funds Transfer (EFT). In some embodiments, consumers and/or merchants are able to effect transaction requests against accounts, using a pseudo-identifier or other identifier, and without the need to provide an account number or card number. In other embodiments, payment networks are able to route and process transaction requests against accounts, without having a card number or account number. In other embodiments, account processing systems are able to determine an appropriate account based on transaction requests that do not contain card numbers or account numbers.

Abstract: Systems, methods, and computer-readable media are provided for processing and settling financial transactions. An example method comprises receiving a transaction from an originator. The transaction comprises information associated with an identification of an initiating user or the account. The method comprises determining the actual account number, transmitting a financial services transaction request comprising the actual account number to a financial institution, receiving a response, and transmitting a response back to the originator. Another method comprises receiving, from a user device, a request to associate a financial account with a user account. The method comprises generating and sending an association message to a payment network and receiving a key associated with the financial account for use in initiating financial transactions. Another method comprises utilizing such a key to generate and process a transaction request. Other systems, methods, and media are also provided.

Abstract: The present invention relates to methods of treating tumours comprising the localised administration, for example, intratumourally or topically, of an epoxytiglienone compound (as a monotherapy) to cancerous tumours to generate a systemic anticancer C abscopal (anenestic) and/or bystander effect.

Abstract: A fluid conduit disinfector includes a conduit with a fluid disinfection channel defined by inner side surface of the conduit, wherein the inner side surface of the conduit is reflective with a germicidal ultraviolet (GUV) light reflectance R of 50%-99%; a GUV light source for emitting GUV light into the fluid disinfection channel; a fan for forcing a fluid to be disinfected to flow through the fluid disinfection channel, and a filter for filtering particles from the fluid. The fluid disinfection channel may include a first section, a second section and a third section, wherein the first section has a cylindrical shape with a first diameter, the third section has a cylindrical shape with a third diameter larger than the first diameter, the second section has a truncated conical shape and is positioned between the first section and the third section.

Abstract: The present invention relates to a combination therapy for tumours comprising the administration of an epoxytigliane compound and an immune checkpoint inhibitor. In particular embodiments, there is a method of treating a tumour and/or treating or preventing one or more bystander tumours with the therapy. Pharmaceutical compositions and kits containing epoxytigliane compounds and immune checkpoint inhibitors are also described.

Abstract: A method of making a fibrous sheet includes providing a first furnish including a primary pulp having papermaking fibers, the papermaking fibers (i) having a weight-weighted average fiber length between about two and seven tenths millimeters and about three millimeters, (ii) a coarseness of about sixteen milligrams per one hundred meters or lower, and (iii) being at least eighty percent of the papermaking fibers of the first furnish, forming a nascent web having at least two layers, one of the at least two layers being (i) a surface layer of the nascent web and (ii) formed from the first furnish, dewatering the nascent web to form a dewatered web, applying the surface layer of the dewatered web to the outer surface of a Yankee drum of a Yankee dryer, and drying the dewatered web with the Yankee dryer to form a fibrous sheet.