Abstract: Oral formulations comprising one or more proteasome inhibitors for use as a treatment of coronavirus infection in a subject. Also disclosed are the use of such for the treatment or prevention of SARS-CoV-2 infection in humans.

Abstract: The present disclosure provides methods and systems for screening or detecting a tumor or following disease progression that may be applied to cell-free nucleic acids, such as cell-free DNA. The method may use detection of methylation signals within a single sequencing read in identified genomic regions as input features to train a machine learning model and generate a classifier useful for stratifying populations of individuals. The method may comprise extracting DNA from a cell-free sample obtained from a subject, converting the DNA for methylation sequencing, generating sequencing reads, detecting proliferative cell disorder-associated signals in the sequencing information, and training a machine learning model to provide a discriminator capable of distinguishing groups in a subject population such as healthy, cancer, or distinguishing disease subtype or stage. The method may be used for, e.g., predicting, prognosticating, and/or monitoring response to treatment, tumor load, relapse, or cancer development.

Abstract: In various embodiments, the invention is a versatile, automated system to allow researchers to continuously measure gas flux rates from multiple chambers over time without (or with reduced) need for personnel in the field. The invention is compatible with any high-frequency analyzer or vial filler and most chamber designs.

Abstract: In various embodiments, the invention is a versatile, automated system to allow researchers to continuously measure gas flux rates from multiple chambers over time without (or with reduced) need for personnel in the field. The invention is compatible with any high-frequency analyzer or vial filler and most chamber designs.

Abstract: A data-processing apparatus is provided. The data-processing apparatus creates and dynamically maintains relationships between operational data and output data. The data-processing apparatus has first line items for storing operational data. The first line items have operational attributes and at least one treatment attribute. The treatment attribute specifies qualifiers used to create qualified operational data. Impact attributes specify destinations for the qualified operational data in a set of second line items which is arranged to hold the output data. The data-processing apparatus is particularly suited to use as a business planning tool.

Abstract: A computer-implemented modular planning tool and method are provided which allow a line item (50) to be joined to another line item (50) so that data attributes (54), data structure (56) and data contained in the data structure (56) are shared by both line items (50). This is achieved using a join attribute of a line item (50) to point to another line item (50).

Abstract: A apparatus is provided for updating data within a business planning tool. The apparatus comprises a computer memory (22) arranged to store operational data in a plurality of line items (50), each line item (50) being arranged to represent operational data in data cells (52) occupying space in a plurality of dimensions (X, Y), and each line item (50) having data cells in a first dimension (Y) configured to represent the operational data in a at least one hierarchy level, and having data cells in a second dimension (X) arranged to represent the respective operational data over at least one time period.

Abstract: Techniques are described for specifying virtual datasets within an enterprise software system. A computer-implemented system, for example, includes an enterprise planning system and a computing device coupled to the enterprise planning system via a network connection. The computing device includes an object store that stores a dataset, an application programming interface (API) that defines an operation for specifying the virtual dataset from the dataset, and an object model that stores a virtual dataset to the object store in response to receiving the operation defined by the API. The computing device further includes a plurality of applications that utilize the virtual dataset for a further operation defined by the API without resolving the virtual dataset.

Abstract: A apparatus is provided for updating data within a business planning tool. The apparatus comprises a computer memory (22) arranged to store operational data in a plurality of line items (50), each line item (50) being arranged to represent operational data in data cells (52) occupying space in a plurality of dimensions (X, Y), and each line item (50) having data cells in a first dimension (Y) configured to represent the operational data in a at least one hierarchy level, and having data cells in a second dimension (X) arranged to represent the respective operational data over at least one time period.

Abstract: A data-processing apparatus is provided. The data-processing apparatus creates and dynamically maintains relationships between operational data and output data. The data-processing apparatus has first line items for storing operational data. The first line items have operational attributes and at least one treatment attribute. The treatment attribute specifies qualifiers used to create qualified operational data. Impact attributes specify destinations for the qualified operational data in a set of second line items which is arranged to hold the output data. The data-processing apparatus is particularly suited to use as a business planning tool.

Abstract: Techniques are described for specifying virtual datasets within an enterprise software system. A computer-implemented system, for example, includes an enterprise planning system and a computing device coupled to the enterprise planning system via a network connection. The computing device includes an object store that stores a dataset, an application programming interface (API) that defines an operation for specifying the virtual dataset from the dataset, and an object model that stores a virtual dataset to the object store in response to receiving the operation defined by the API. The computing device further includes a plurality of applications that utilize the virtual dataset for a further operation defined by the API without resolving the virtual dataset.

Abstract: Methods, systems, and computer program products sustain a fleet of configuration-controlled assets. The method involves integrating a plurality of previously separate systems with reusable business transactions associated with managing a fleet of vehicles. The method also involves receiving operational data associated with a vehicle of the fleet, integrating the operational data per customer requirements, packaging and distributing the operational data to the plurality of systems, and installing and distributing the operational data to one or more applications of the plurality of systems utilizing reusable business transactions. The system utilizes a plurality of applications and a plurality of logical subsystems, which are connected to each other through gateways. The logical subsystems use a common format defined by a set of messages. However, the applications can use a plurality of different formats.

Abstract: A cyclone separator assembly comprising a pressure vessel divided internally by first and second generally parallel dividing plates to define an overflow chamber, an underflow chamber, and an inlet chamber intermediate the overflow and underflow chambers, the dividing plates having aligned bores therein for receiving and supporting respective end regions of respective cyclone separator tubes, the ends of the bores in the first dividing plate opening into the overflow chamber being partially obstructed by restraining means restricting displacement of the cyclone tubes in a direction towards the overflow chamber.