Abstract: The present disclosure relates to: a) crystalline forms of N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide; b) pharmaceutical compositions comprising one or more crystalline forms of N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide, and, optionally, one or more pharmaceutically acceptable carriers; c) methods of treating a tumor a cancer, or a Rasopathy disorder by administering one or more crystalline forms of N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide to a subject in need thereof; and methods of producing essentially pure Form IV of N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide.

Abstract: Aspects of the present disclosure include systems and methods for generating and managing user authentication rules of a computing device. In an example, a computing device may include a memory storing instructions and a processor communicatively coupled with the memory and configured to execute the instructions. The processor may determine a state of the computing device, wherein the state of the computing device is one of a locked state or an unlocked state. The processor may determine a user authentication rule corresponding to the state of the computing device. The processor may also identify whether a combination of signals associated with the user authentication rule of the computing device are received by the computing device. The processor may also change or maintain the state of the computing device based on the combination of signals being received.

Abstract: A communal computing device, such as an interactive digital whiteboard, can become unlocked if a user is near the device. The communal computing device may use a sensor such as a camera to capture images of a person and obtain an identifier from a personal device such as a smartphone. A cloud-based provider that is trusted by both the communal computing device and the personal device may associate both the image and the identifier of the personal device with the same user identity. Obtaining the user identity from multiple, different sources provides a secure technique for the communal computing device to recognize a user without the user directly interacting with the communal computing device. If the sensor no longer detects the user or the personal device is no longer detected, then the communal computing device may log off the user. The personal device may be used to confirm log off.

Abstract: The present disclosure relates to: a) crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide, h) pharmaceutical compositions comprising one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide, and, optionally, one or more pharmaceutically acceptable carriers; c) methods of treating a tumor a cancer, or a Rasopathy disorder by administering one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide to a subject in need thereof; and methods of producing essentially pure Form IV of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide.

Abstract: The present disclosure relates to: a) crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide; b) pharmaceutical compositions comprising one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide, and, optionally, one or more pharmaceutically acceptable carriers; c) methods of treating a tumor a cancer, or a Rasopathy disorder by administering one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide to a subject in need thereof; and methods of producing essentially pure Form IV of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide.

Abstract: A system and method to identify a digital representation of a first musical composition including a set of musical blocks. A set of parameters associated with video content are identified. In accordance with one or more rules, one or more of the set of musical blocks of the first musical composition are modified based on the set of parameters to generate a derivative musical composition corresponding to the video content. An audio file including the derivative musical composition corresponding to the video content is generated.

Abstract: A communal computing device, such as an interactive digital whiteboard, can become unlocked if a user is near the device. The communal computing device may use a sensor such as a camera to capture images of a person and obtain an identifier from a personal device such as a smartphone. A cloud-based provider that is trusted by both the communal computing device and the personal device may associate both the image and the identifier of the personal device with the same user identity. Obtaining the user identity from multiple, different sources provides a secure technique for the communal computing device to recognize a user without the user directly interacting with the communal computing device. If the sensor no longer detects the user or the personal device is no longer detected, then the communal computing device may log off the user. The personal device may be used to confirm log off.

Abstract: A user provides an identification (ID) signal (e.g. a biometric ID signal like a self-snapshot) to a trusted cloud-based provider. When the user attempts to authenticate with the cloud-based provider, a similar ID signal (e.g. another self-snapshot) for the user is captured and provided to the cloud-based provider. The cloud-based provider then obtains a secondary ID signal, or a combination of secondary ID signals, and utilizes the secondary ID signal, or signals, to identify a subset of user records to be searched for the ID signal. The subset of the records, rather than all of the user records, can then be searched for the ID signal. The cloud-based provider can then authenticate the user based on the results of the search of the subset of the user records.

Abstract: A user provides an identification (ID) signal (e.g. a biometric ID signal like a self-snapshot) to a trusted cloud-based provider. When the user attempts to authenticate with the cloud-based provider, a similar ID signal (e.g. another self-snapshot) for the user is captured and provided to the cloud-based provider. The cloud-based provider then obtains a secondary ID signal, or a combination of secondary ID signals, and utilizes the secondary ID signal, or signals, to identify a subset of user records to be searched for the ID signal. The subset of the records, rather than all of the user records, can then be searched for the ID signal. The cloud-based provider can then authenticate the user based on the results of the search of the subset of the user records.

Abstract: Process vessels can contain one or more entry zones containing stability-improving materials. The entry zones address bed movement and filtration problems. The stability-improving material can be positioned above a treating zone or above a processing bed within the vessel. Entry Zones are intended to improve the stability of downstream operations.

Abstract: Various implementations disclosed herein include devices, systems, and methods for configuring objective-effectuators. A device includes a display, a non-transitory memory and one or more processors coupled with the display and the non-transitory memory. A method includes, while displaying a computer-generated reality (CGR) representation of a first objective-effectuator in a CGR environment, determining to display a CGR representation of a second objective-effectuator in association with the CGR representation of the first objective-effectuator. In some implementations, the second objective-effectuator is associated with a set of configuration parameters. In some implementations, the method includes determining a value for at least a first configuration parameter of the set of configuration parameters based on a type of the first objective-effectuator.

Abstract: A method for facilitating the distribution of the flow of one or more streams within a bed vessel is provided. Disposed within the bed vessel are internal materials and structures including multiple operating zones. One type of operating zone can be a processing zone composed of one or more beds of solid processing material. Another type of operating zone can be a treating zone. Treating zones can facilitate the distribution of the one or more streams fed to processing zones. The distribution can facilitate contact between the feed streams and the processing materials contained in the processing zones.

Abstract: Aspects of the present disclosure include systems and methods for generating and managing user authentication rules of a computing device. In an example, a computing device may include a memory storing instructions and a processor communicatively coupled with the memory and configured to execute the instructions. The processor may determine a state of the computing device, wherein the state of the computing device is one of a locked state or an unlocked state. The processor may determine a user authentication rule corresponding to the state of the computing device. The processor may also identify whether a combination of signals associated with the user authentication rule of the computing device are received by the computing device. The processor may also change or maintain the state of the computing device based on the combination of signals being received.

Abstract: A communal computing device, like an interactive digital whiteboard, can detect the start and end of user sessions with the device. When a communal computing device detects the end of a user session, the it can determine if a personal device that was connected at the start of the user session or during the user session was also connected at the end of the user session. If so, the device can initiate actions based on the session start or end signals such as, but not limited to, transmitting a message to an organizer of a meeting scheduled during the time of the user session, transmitting a message to a participant of a meeting scheduled during the time of the user session, transmitting a message to an administrator, or generating a notification, such as a user interface reminding a user to take their personal device.

Abstract: A system and method to identify a digital representation of a first musical composition including a set of musical blocks. A set of parameters associated with source content are identified. In accordance with one or more rules, one or more of the set of musical blocks of the first musical composition are modified based on the set of parameters to generate a derivative musical composition. An audio file including the derivative musical composition is generated.

Abstract: A method for facilitating the distribution of the flow of one or more streams within a bed vessel is provided. Disposed within the bed vessel are internal materials and structures including multiple operating zones. One type of operating zone can be a processing zone composed of one or more beds of solid processing material. Another type of operating zone can be a treating zone. Treating zones can facilitate the distribution of the one or more streams fed to processing zones. The distribution can facilitate contact between the feed streams and the processing materials contained in the processing zones.

Abstract: A method for enabling gas exchange and chemical reactions with one or more liquid streams contained in a reactive process vessel are provided. One or more exchange layers within the process vessel can be composed of both collector media and releaser media. The exchange layers allow elements to facilitate increased performance of vessel operations by promoting gas component mixing and diffusion. Improved rates of gas component exchange mean less coking and more gas components available for reaction.

Abstract: The present disclosure relates to a) crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide; b) pharmaceutical compositions comprising one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide, and, optionally, one or more pharmaceutically acceptable carriers; c) methods of treating a tumor a cancer, or a Rasopathy disorder by administering one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide to a subject in need thereof, and methods of producing essentially pure Form IV of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide.

Abstract: A device may receive first information that includes a first data element. The device may receive second information that includes a second data element. The first data element and the second data element may be associated with different area identifiers. The device may associate the first information and the second information with a geographic area. The device may determine, for the geographic area, a first data element score based on the first data element. The device may determine, for the geographic area, a second data element score based on the second data element. The device may determine, for the geographic area, a market index based on the first data element score and the second data element score. The device may provide information regarding the market index to permit and/or cause an action to be performed in association with the geographic area.

Abstract: A method for enabling gas exchange and chemical reactions with one or more liquid streams contained in a reactive process vessel are provided. One or more exchange layers within the process vessel can be composed of both collector media and releaser media. The exchange layers allow elements to facilitate increased performance of vessel operations by promoting gas component mixing and diffusion. Improved rates of gas component exchange mean less coking and more gas components available for reaction.