Patents by Inventor Peter Grogg

Peter Grogg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Resin-linker combination for the solid-phase synthesis of peptides and intermediates
    Patent number: 4914151
    Abstract: The present invention relates to a novel polymeric carrier, a process for its production and its use for the preparation of peptides and their intermediates. The process comprises reacting chloromethylated polystyrene (cross-linked with divinylbenzene) with a 4-hydroxy-2-substituted-benzyl alcohol (linker), attaching .alpha.-amino acids with amino and side-chain protection to the carrier thus obtained, and building up a peptide according to the method known in the field of solid phase peptide synthesis (SPPS). The method allows removal of intermediates or final products under extremely mild acidic conditions giving products in high state of purity and yield. The 2-substituent consists of an electron donating group, such as methoxy.
    Type: Grant
    Filed: March 29, 1989
    Date of Patent: April 3, 1990
    Assignee: Bachem Feinchemikalein A.G.
    Inventors: Monika Mergler, Jacques Gosteli, Peter Grogg
  • Resin-linker combination for the solid-phase synthesis of peptides and intermediates
    Patent number: 4831084
    Abstract: The present invention relates to a novel polymeric carrier, a process for its production and its use for the preparation of peptides and their intermediates. The process comprises reacting chloromethylated polystyrene (cross-linked with divinylbenzene) with a 4-hydroxy-2-substituted-benzyl alcohol (linker), attaching .alpha.-amino acids with amino and side-chain protection to the carrier thus obtained, and building up a peptide according to the method known in the field of solid phase peptide synthesis (SPPS). The method allows removal of intermediates or final products under extremely mild acidic conditions giving products in high state of purity and yield. The 2-substituent consists of an electron donating group, such as methoxy.
    Type: Grant
    Filed: May 2, 1988
    Date of Patent: May 16, 1989
    Assignee: Bachem Feinchemikalien A.G.
    Inventors: Monika Mergler, Jacques Gosteli, Peter Grogg