Patents by Inventor Peter Grootenhuis

Peter Grootenhuis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulators of ATP-binding cassette transporters
    Publication number: 20070264196
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: March 13, 2006
    Publication date: November 15, 2007
    Inventors: Sara Ruah, Anna Hazlewood, Peter Grootenhuis, Jinglan Zhou
  • Modulators of ATP-binding cassette transporters
    Publication number: 20070244159
    Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Application
    Filed: April 9, 2007
    Publication date: October 18, 2007
    Inventors: Sara Hadida Ruah, Peter Grootenhuis, Frederick Van Goor, Jinglan Zhou, Brian Bear, Mark Miller, Jason McCartney, Mehdi Numa
  • Substituted thiazoles and oxazoles as corticotropin releasing hormone ligands
    Patent number: 7276526
    Abstract: Provided herein are novel substituted thiazoles and oxazoles of the Formula (I): as well as compositions, including pharmaceutical compositions, containing the same, and the use thereof in the treatment of various neurological and psychological disorders, e.g., affective disorder, anxiety and depression, treatable by antagonizing CRF receptors.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: October 2, 2007
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Andreas Termin, Peter Grootenhuis, Dean Wilson, Valentina Molteni, Long Mao
  • Modulators of ATP-binding cassette transporters
    Publication number: 20070105833
    Abstract: 4-amido-pyrimidine compounds, derivatives and compositions thereof, and synthetic methods described herein are useful for modulating ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: May 22, 2006
    Publication date: May 10, 2007
    Inventors: Sara Ruah, Anna Hazlewood, Peter Grootenhuis, Ashvani Singh, Thomas Cleveland, Frederick Van-Goor
  • Quinazolines useful as modulators of ion channels
    Publication number: 20060217377
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: September 2, 2004
    Publication date: September 28, 2006
    Inventors: Jesus Gonzalez, Dean Wilson, Andreas Termin, Peter Grootenhuis, Yulian Zhang, Benjamin Petzoldt, Lev Fanning, Timothy Neubert, Roger Tung, Esther Martinborough, Nicole Zimmerman
  • Modulators of ATP-binding cassette transporters
    Publication number: 20060074075
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: June 24, 2005
    Publication date: April 6, 2006
    Inventors: Sara Hadida-Ruah, Anna Hazelwood, Peter Grootenhuis, Fred Goor, Ashvani Singh, Jinglan Zhou, Jason McCartney
  • Modulators of ATP-binding cassette transporters
    Publication number: 20060052358
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: January 31, 2005
    Publication date: March 9, 2006
    Inventors: Sarah Ruah, Peter Grootenhuis, Mark Miller, Matthew Hamilton
  • Organic compounds
    Patent number: 6949669
    Abstract: Compounds of general formula (I) wherein the substituents are as defined in claim 1 are suitable for use as herbicides
    Type: Grant
    Filed: January 23, 2001
    Date of Patent: September 27, 2005
    Assignee: Syngenta Crop Protection, Inc.
    Inventors: Gerald Wayne Craig, Martin Eberle, Martin Zeller, Steven Scott Bondy, Daniel Dennis Comer, Soan Cheng, Julie Elizabeth Penzotti, Peter Grootenhuis, Jürg Ehrler
  • Modulators of ATP-Binding Cassette transporters
    Publication number: 20050176789
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: September 7, 2004
    Publication date: August 11, 2005
    Inventors: Sara Hadida Ruah, Mark Miller, Ashvani Singh, Thomas Cleveland, Lewis Makings, Matthew Hamilton, Peter Grootenhuis
  • Modulators of muscarinic receptors
    Publication number: 20050171141
    Abstract: The modulator compounds described herein modulate muscarinic receptors and are useful for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: December 7, 2004
    Publication date: August 4, 2005
    Inventors: Peter Grootenhuis, Miguel Garcia-Guzman Blanco, Lewis Makings, Philip Martin Londo
  • Modulators of ATP-binding cassette transporters
    Publication number: 20050148648
    Abstract: The present invention provides compounds of Formula I useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein RB, n, B, RC, RD, RE, A, and Z are described generally and in classes and subclasses below. The present invention also provides pharmaceutical compositions, methods and kits associated with Formula I, useful for as modulators, and for the treatments of disease and disease conditions associated with ABC transporter proteins.
    Type: Application
    Filed: October 8, 2004
    Publication date: July 7, 2005
    Inventors: Sara Hadida Ruah, Ashvani Singh, Mark Miller, Matthew Hamilton, Peter Grootenhuis
  • Phenyl-piperazine derivatives as modulators of muscarinic receptors
    Publication number: 20050137211
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: September 27, 2004
    Publication date: June 23, 2005
    Inventors: Miguel Blanco, Daniele Bergeron, Peter Grootenhuis, Dennis Hurley, Akiko Nakatani, Lewis Makings, Daniel DiSepio, Gabriel Raffai
  • Thiazoles and oxazoles useful as modulators of ATP-Binding Cassette transporters
    Publication number: 20050130970
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: November 15, 2004
    Publication date: June 16, 2005
    Inventors: Mark Miller, Sarah Ruah, Peter Grootenhuis, Matthew Hamilton
  • Modulators of ATP-binding cassette transporters
    Publication number: 20050113423
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: March 12, 2004
    Publication date: May 26, 2005
    Inventors: Frederick VanGoor, Sara Ruah, Ashvani Singh, Eric Olson, Lewis Makings, Jesus Gonzalez, James Rader, Fred Chambers, Mark Miller, Peter Grootenhuis, Yahua Liu
  • Modulators of ATP-Binding Cassette transporters
    Publication number: 20050059687
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: June 7, 2004
    Publication date: March 17, 2005
    Inventors: Lewis Makings, Ashavini Singh, Mark Miller, Sarah Ruah, Peter Grootenhuis, Matthew Hamilton, Anna Hazlewood, Liming Huang
  • Modulators of VR1 receptor
    Publication number: 20050004133
    Abstract: The present invention relates to compounds useful as modulators of the vanilloid receptor, and also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: June 4, 2004
    Publication date: January 6, 2005
    Inventors: Lewis Makings, Peter Grootenhuis, Dennis Hurley, Roger Tung, Andreas Termin
  • Organic compounds
    Publication number: 20040049065
    Abstract: Compounds of general formula (I) wherein the substituents are as defined in claim 1 are suitable for use as herbicides.
    Type: Application
    Filed: October 18, 2002
    Publication date: March 11, 2004
    Inventors: Gerald Wayne Craig, Martin Eberle, Martin Zeller, Steven Scott Bondy, Daniel Dennis Comer, Soan Cheng, Julie Elizabeth Penzotti, Peter Grootenhuis, Jurg Ehrler
  • Substituted thiazoles and oxazoles as corticotropin releasing hormone ligands
    Publication number: 20030114502
    Abstract: Provided herein are novel substituted thiazoles and oxazoles of the Formula (I): 1
    Type: Application
    Filed: July 10, 2002
    Publication date: June 19, 2003
    Inventors: Andreas Termin, Peter Grootenhuis, Dean Wilson, Valentina Molteni
  • Synthetic polysaccharides, preparation method therefor and pharmaceutical compositions containing same
    Patent number: 6534481
    Abstract: A synthetic polysaccharide including an antithrombin III binding domain consisting of a concatenation of five monosaccharides supporting a total of two carboxylic acid functions and at least four sulpho groups, said domain being directly bound at the non-reducing end by a thrombin binding domain including a concatenation of 10-25 monosaccharide units selected from hexoses, pentoses or deoxy sugars of which all the hydroxyl groups are etherified by a C1-6 alkyl group or esterified in the form of sulpho groups, as well as salts and particularly pharmaceutically acceptable salts thereof, are disclosed.
    Type: Grant
    Filed: September 7, 1999
    Date of Patent: March 18, 2003
    Assignees: Sanofi-Synthelabo, Akzo Nobel
    Inventors: Pierre Alexandre Driguez, Philippe Duchaussoy, Jean Marc Herbert, Maurice Petitou, Constant Van Boeckel, Peter Grootenhuis, Johannes Basten, Cornelia Dreef-Tromp