Patents by Inventor Peter Guillaume Marie Wuts

Peter Guillaume Marie Wuts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for preparing 7-carboxy substituted steroids
    Patent number: 7196208
    Abstract: This invention relates to processes for the preparation of 7-carboxy substituted steroid compounds of Formula I, wherein R1 is selected from H or COR4; R4 is C1–C6 alkyl or C1–C6 alkoxy; R3 is C1–C6 alkyl; Z1 is —CH2— or ?wherein O—COR4 is in the ? configuration; Z2 is —CH—; or Z1 and Z2 may be taken together to form a carbon-carbon double bond; Q is These intermediates are useful in the preparation of 7-carboxy substituted steroid compounds, and particularly, the invention is directed to novel and advantageous methods for the preparation of 9,11-?-epoxy-17-?-hydroxy-3-oxopregn-4-ene-?-7-21-dicarboxylic acid, ?-lactone, methyl ester (eplerenone; epoxymexrenone).
    Type: Grant
    Filed: March 21, 2003
    Date of Patent: March 27, 2007
    Inventor: Peter Guillaume Marie Wuts
  • 5-androsten-3?-ol steroid intermediates and processes for their preparation
    Patent number: 7002028
    Abstract: The present invention provides 5-androsten-3?-ol steroid intermediates and processes for their preparation.
    Type: Grant
    Filed: June 1, 2004
    Date of Patent: February 21, 2006
    Assignee: Warner-Lambert Company
    Inventors: Michael J. White, Peter Guillaume Marie Wuts, Doris Beck
  • Microbial method for hydrolysis and oxidation of androst-5-ene and pregn-5-ene steroid esters
    Publication number: 20040265948
    Abstract: A microbial method for hydrolysis and oxidation of androst-5-ene and pregn-5-ene steroid esters is disclosed.
    Type: Application
    Filed: May 10, 2004
    Publication date: December 30, 2004
    Inventors: Michael Jon White, Doris M. Beck, Peter Guillaume Marie Wuts, Ivan Gale Gilbert
  • 5-Androsten-3beta-ol steroid intermediates and processes for their preparation
    Publication number: 20040220158
    Abstract: The present invention provides 5-androsten-3&bgr;-ol steroid intermediates and processes for their preparation.
    Type: Application
    Filed: June 1, 2004
    Publication date: November 4, 2004
    Inventors: Michael J. White, Peter Guillaume Marie Wuts, Doris Beck
  • Process for preparing S-(2-aminoethyl)-2-methyl-L-cysteine
    Publication number: 20040122099
    Abstract: The instant invention provides a process for the preparation of S-(2-aminoethyl)-2-methyl-L-cysteine comprised of the steps of (i) esterification of 2-methyl-L-cysteine; (ii) alkylation of the cysteine ester of step (i) to provide an N-protected S-(2-aminoethyl)-2-methyl-L-cysteine ester; and (iii) hydrolysis of the intermediate of step (ii) to provide the title compound in a salt free state.
    Type: Application
    Filed: October 29, 2003
    Publication date: June 24, 2004
    Inventor: Peter Guillaume Marie Wuts
  • Processes for preparing C-7 substituted steroids
    Publication number: 20040097475
    Abstract: This invention relates to processes for the preparation of novel 7-carboxy substituted steroid compounds of Formula I, 1
    Type: Application
    Filed: March 21, 2003
    Publication date: May 20, 2004
    Inventor: Peter Guillaume Marie Wuts
  • Processes for preparing 7-carboxy substituted steroids
    Publication number: 20040087562
    Abstract: This invention relates to processes for the preparation of 7-carboxy substituted steroid compounds of Formula I, 1
    Type: Application
    Filed: March 21, 2003
    Publication date: May 6, 2004
    Inventor: Peter Guillaume Marie Wuts
  • 5-Androsten-3beta-ol steroid intermediates and processes for their preparation
    Publication number: 20040034215
    Abstract: The present invention provides 5-androsten-3&bgr;-ol steroid intermediates and processes for their preparation.
    Type: Application
    Filed: March 21, 2003
    Publication date: February 19, 2004
    Inventors: Michael J. White, Peter Guillaume Marie Wuts, Doris Beck
  • Process to prepare (5R)-(methylamino)-5, 6-dihydro-4H-imidazo[4,5,1-ij]-quinolin-2(1H)-one
    Patent number: 6586595
    Abstract: The present invention is an improved prosess to prepare (5R)-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one the compound of formula (VII)
    Type: Grant
    Filed: August 22, 2001
    Date of Patent: July 1, 2003
    Assignee: Pharmacia & Upjohn Company
    Inventor: Peter Guillaume Marie Wuts
  • Aminohydroxylation of olefins in the presence of acetamide
    Patent number: 6509491
    Abstract: The present invention is a process to prepare on of a phenylisoserine ester of the formula (II) &phgr;—CH(NH—CO—CH3)—CH(OH)—CO—O—R1 with reduced amount of diol by-product by the use of a compound of the formula R2—CO—NH2 where R2 is C1-C6 alkyl with the proviso that R2 is not tertiary.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: January 21, 2003
    Assignee: Pharmacia & Upjohn Company
    Inventor: Peter Guillaume Marie Wuts
  • Process to prepare (5R)-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]-quinolin-2(1H)-one
    Publication number: 20020183520
    Abstract: The present invention is an improved prosess to prepare (5R)-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one the compound of formula (VII)
    Type: Application
    Filed: August 22, 2001
    Publication date: December 5, 2002
    Inventor: Peter Guillaume Marie Wuts
  • Process to prepare (5R)-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]-quinolin-2(1h)-one
    Patent number: 6355802
    Abstract: The present invention is an improved prosess to prepare (5R)-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one the compound of formula (VII).
    Type: Grant
    Filed: January 31, 2000
    Date of Patent: March 12, 2002
    Assignee: Pharmacia & Upjohn COmpany
    Inventor: Peter Guillaume Marie Wuts
  • Aminohydroxylation of olefins in the presence of acetamide
    Publication number: 20010029306
    Abstract: The present invention is a process to prepare on of a phenylisoserine ester of the formula (II)
    Type: Application
    Filed: February 28, 2001
    Publication date: October 11, 2001
    Inventor: Peter Guillaume Marie Wuts