Abstract: The present disclosure relates generally to a class of sulfonamide-based compounds, compositions containing the same and the therapeutic use of the compounds in the treatment of cancer.

Abstract: Provided an apparatus and method for carbonation treatment capable of efficiently carrying out a carbonation treatment. Provided is a carbonation treatment apparatus for subjecting a solid matter contained in a treatment object to a carbonation treatment by bringing the treatment object into contact with carbon dioxide while stirring the treatment object. The apparatus includes: a reaction vessel having a housing space in which the treatment object is housed; at least one stirrer that rotates about a vertically extending axis to stir the treatment object housed in the housing space; and the at least one stirrer being configured to move in planetary motion in the housing space when the treatment object is stirred.

Abstract: A material handling system is described. The material handling system comprises a rigid frame and a moveable liner. The frame includes at least one aperture having an area and wherein the system comprises an actuator system for applying a force to a surface of the liner in the area of the aperture.

Abstract: The present disclosure relates to compounds having the following formula (I): or pharmaceutically acceptable salts, hydrates, derivatives or solvates thereof. Compounds of formula (I) disrupt the activity of the tropomyosin isoform Tpm4.2.

Abstract: The present disclosure relates generally to a class of sulfonamide-based compounds, compositions containing the same and the therapeutic use of the compounds in the treatment of cancer.

Abstract: The present disclosure relates generally to a class of quinazoline compounds, compositions containing the same and the therapeutic use of the compounds in the treatment of cancer.

Abstract: The present invention relates to anti-tropomyosin compounds, processes for their preparation, and methods for treating or preventing a proliferative disease, preferably cancer, using compounds of the invention.

Abstract: The present invention relates to anti-tropomyosin compounds, processes for their preparation, and methods for treating or preventing a disease or disorder, such as a proliferative disease (preferably cancer), using compounds of the invention.

Abstract: The present invention relates to anti-tropomyosin compounds, processes for their preparation, and methods for treating or preventing a disease or disorder, such as a proliferative disease (preferably cancer), using compounds of the invention.

Abstract: The invention relates to methods of screening for compounds that regulate the activity of cell surface proteins. The present invention relates to a method for regulating the insertion or retention of a protein, such as the cystic fibrosis transmembrane conductance regulator (CFTR), in a cell surface membrane. The invention also relates to methods for the diagnosis and treatment or prevention of diseases caused by abnormal insertion or activity of a cell surface membrane protein, such as cystic fibrosis.