Patents by Inventor Peter H. Ermann

Peter H. Ermann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclic hydrazide derivatives of monocyclic .beta.-lactam antibiotics
    Patent number: 5318963
    Abstract: Antibacterial activity has been found in compounds of the formula.Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein: A is a bond or alkylene;Q completes a 5- or 6-membered saturated or unsaturated (including aromatic) heterocyclic ring having one or two, heteroatoms in the ring selected from nitrogen, ##STR2## sulfur or oxygen; X is attached to an available carbon atom in the heterocyclic ring and is hydrogen or oxo;Y is attached to an available carbon atom in the heterocyclic ring and is hydrogen, amino, hydroxyl, halogen, carboxamide, nitrile, or carboxyl, except that Y is not carboxyl when the bicyclic ring completed by Q is 2-quinolyl, 3-quinolyl, or quinoxalyl;and the remaining symbols are as defined in the specification.
    Type: Grant
    Filed: November 30, 1990
    Date of Patent: June 7, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter H. Ermann, Henner Straub
  • 4-methoxy-5-methyl-pyran-3-ol natural products and derivatives thereof
    Patent number: 5270334
    Abstract: Novel antibiotic substances, including novel natural products, having the general formula ##STR1## wherein R.sub.1 and R.sub.2 are as defined herein, are disclosed. These compounds have been found to be cytochrome P450 inhibitors.
    Type: Grant
    Filed: July 1, 1992
    Date of Patent: December 14, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Joseph O'Sullivan, Douglas W. Phillipson, Henner Straub, Peter H. Ermann
  • 6,7-dihydroxyquinoxalines as intermediates to beta-lactam antibiotics
    Patent number: 5037983
    Abstract: Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof and possessing antibacterial activiy, and intermediates to compounds of formula I having the formula ##STR2##
    Type: Grant
    Filed: December 1, 1989
    Date of Patent: August 6, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Joseph E. Sundeen, Peter H. Ermann
  • Heteroaroylhydrazide derivatives of monocyclic beta-lactam antibiotics
    Patent number: 4904775
    Abstract: Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof and possessing antibacterial activity, and intermediates to compounds of formula I having the formula
    Type: Grant
    Filed: May 16, 1988
    Date of Patent: February 27, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Joseph E. Sundeen, Peter H. Ermann
  • 2-Oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines
    Patent number: 4871841
    Abstract: Antibacterial activity is exhibited by 2-azetidinones having a 3-acylamino substituent and having an activating group in the 1-position of the formula ##STR1## wherein R.sub.4 is ##STR2## wherein A.sub.1 is a single bond, ##STR3## --NH-- or ##STR4## A.sub.2 is a single bond, --NH--, --CH.sub.2 --CH.sub.2 --NH-- or ##STR5## A.sub.3 is a single bond, --CH.dbd.CH--, --(CH.sub.2).sub.t --, --NH--(CH.sub.2).sub.p -- or ##STR6## wherein t is 1, 2, 3 or 4 and p is 0 or 1; and A.sub.4 is a single bond --CH.sub.2 --, --NH--CH.sub.2 --, or --N.dbd.CH--.
    Type: Grant
    Filed: December 23, 1987
    Date of Patent: October 3, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Peter H. Ermann
  • 2-oxo-1-(((substituted sulfonyl)amino)-carbonyl)azetidines
    Patent number: 4801705
    Abstract: Antibacterial activity is exhibited by .beta.
    Type: Grant
    Filed: June 23, 1986
    Date of Patent: January 31, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Hermann Breuer, Jakob-Matthias Drossard, Peter H. Ermann, Henner Straub, Uwe D. Treuner
  • 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines
    Patent number: 4777252
    Abstract: Antibacterial activity is exhibited by 3-acylamino-2-oxoazetidines having in the 1-position an activating group of the formula ##STR1## wherein R is ##STR2## and R.sub.
    Type: Grant
    Filed: August 13, 1987
    Date of Patent: October 11, 1988
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: William A. Slusarchyk, Peter H. Ermann
  • N-hydroxy protecting groups and process for the preparation of 3-acylamino-1-hydroxy-2-azetidinones
    Patent number: 4633017
    Abstract: Processes for preparing the useful intermediates having the formula ##STR1## are disclosed herein, utilizing novel chemical compounds having the formula ##STR2##
    Type: Grant
    Filed: October 24, 1985
    Date of Patent: December 30, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Richard H. Mueller, Jakob-Matthias Drossard, Peter H. Ermann
  • N-hydroxyl protecting groups and process and intermediates for the preparation of 3-acylamino-1-hydroxy-2-azetidinones
    Patent number: 4581170
    Abstract: Processes for preparing the useful intermediates having the formula ##STR1## are disclosed herein, utilizing novel chemical compounds having the formula ##STR2##
    Type: Grant
    Filed: August 3, 1984
    Date of Patent: April 8, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Richard H. Mueller, Jakob-Matthias Drossard, Peter H. Ermann