Abstract: Novel .alpha.-phenyl-2-(aza)benzothiazolylthioglycolic acids, derivatives thereof and pharmacologically acceptable salts thereof are disclosed, as well as their use as intermediates in the preparation of 2-substituted-3-hydroxy-thiazolo[2,3-b]-benzothiazolium salts, 2-substituted-thiazolo[2,3-b]benzothiazol-3(2H)-one mesoionic didehydro derivatives, 2-substituted-thiazolo[2',3'-2,3]thiazolo[5,4-b]pyridin-3(2H)-one mesoionic didehydro derivatives and related compounds, and their use as modulators of the immune response.

Abstract: There are disclosed compounds having the formula ##STR1## wherein R.sup.1 is hydrogen, lower alkyl, trifluoromethyl or halo;R.sup.2 is hydrogen, trifluoromethyl or halo; andR.sup.3 is hydrogen, nitro or carboxy;which possess lipoxygenase and cyclo-oxygenase inhibitory activity, making them useful as anti-inflammatory agents and which also possess analgesic activity.

Abstract: .alpha.-Mercaptobenzylacetic acid derivatives of imidazole-containing compounds and analogues thereof, and their use as immunomodulating agents are disclosed.

Abstract: Thioacetonitriles and other derivatives of benzo- and azabenzothiazoles and their use as antiviral agents are disclosed.

Abstract: Thioacetonitrile of imidazo- and triazolo pyridines and their use as antiviral agents are disclosed.

Abstract: The compounds of this invention are designated as quinoxalinyl esters of carbamimidothioic acids and exhibit the pharmacological properties of preventing gastric ulcers, reducing gastric secretions and lowering blood pressure. The compounds have the following structural formula: ##STR1## in which Q is hydrogen or nitro;A is hydrogen, methyl, ethyl, propyl, isopropyl, n-butyl, carbomethoxy, carbethoxy, carbopropoxy, carbisopropoxy, carbobutoxy, carbisobutoxy, or carbo-t-butoxy; andR.sup.1, R.sup.2, and R.sup.3 are, independently, hydrogen, methyl, ethyl, propyl, isopropyl, n-butyl, isobutyl, t-butyl, allyl, or R.sup.1 and R.sup.3 may be concatenated with a carbon chain having 4 carbon atoms with R.sup.2 then being hydrogen; except that, when A and Q are hydrogen, R.sup.1, R.sup.2, and R.sup.3 may not all be hydrogen; and with the further exception that, where A is methyl and R.sup.1, R.sup.2, and Q are all hydrogen, R.sup.3 may not be ethyl;or a pharmaceutically acceptable salt thereof.

Abstract: Novel 2-substituted-3-hydroxythiazolo[2,3-b]thiazolium salts, the mesoionic didehydro derivatives thereof and related compounds and their use as modulators of the immune response are disclosed.

Abstract: 3-Hydroxy-3-substituted phenylthiazolo[2,3-b]quinazoline-2-acetic acids, their lactones and related compounds, and their use as immunomodulating agents are disclosed.

Abstract: 3-Substituted phenythiazolo[3'2':1,2]imidazo[4,5-b]pyridine-2-alkanoic acids and their use as immunomodulating agents are disclosed.

Abstract: Substituted 4-hydroxy-2,3-alkylene thiazolium salts are anti-secretory agents useful in the treatment of peptic ulcer disease.

Abstract: Novel 2-substituted-3-hydroxythiazolo[2,3-b]benzo-(and azabenzo)thiazolium salts, the mesoionic didehydro derivatives thereof and related compounds are disclosed, as well as the use thereof as modulators of the immune response.

Abstract: The use of 3-aryl-thiazolo[3,2-a]benzimidazoles, 3-aryl-imidazo[2,1-b]thiazoles, and related compounds as antineoplastic agents, and/or as enhancers of the immune response is disclosed.

Abstract: The antibacterial agents of this invention present the following structural formula: ##SPC1##In whichR.sup.1 is --OH, alkoxycarbonyloxy of 2 to 6 carbon atoms, arylsulfonyl of 6 to 10 carbon atoms or thiocyanato;R.sup.2 is --H, halo or phenyl;R.sup.3 is --H, an alkali metal or --NH.sub.4 ; andY is ##EQU1## wherein R.sup.

Abstract: Compounds of the formula: ##SPC1##Wherein R is hydrogen, lower alkyl, halogen, nitro, trifluoromethyl, or lower alkoxy; and n is 2, 3, or 4; and the non-toxic pharmaceutically acceptable acid addition salts thereof; have CNS-depressant activity.

Abstract: The antibacterial agents of this invention present the following structural formula: ##SPC1##In whichA is a member selected from the group consisting of ##EQU1## M is a member selected from the group consisting of --H, an alkali metal and --NH.sub.4 ; andY is a member selected from the group consisting of ##EQU2## wherein R is --H, alkanoyloxy of 2 to 6 carbon atoms, ##SPC2##Or,When taken with the 3-carboxy group, ##SPC3## .

Abstract: The invention provides anti-bacterial agents of the formula: ##SPC1##R.sup.1 is a member selected from the group consisting of --Cl and ##SPC2##R.sup.2 is a member selected from the group consisting of --H and acetoxy; andM is a member selected from the group consisting of --H, an alkali metal and --NH.sub.4.