Patents by Inventor Peter H. Seeburg

Peter H. Seeburg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Glycoprotein hormone receptor molecules
    Publication number: 20020061557
    Abstract: The invention relates to the purification, and cloning of receptors for the luteinizing hormone, choriogonadotropin, follicle stimulating hormone, and thyroid stimulating hormone. The invention additionally concerns the uses for such molecules in the diagnosis and therapy of human conditions.
    Type: Application
    Filed: June 7, 2001
    Publication date: May 23, 2002
    Applicant: Genentech, Inc.
    Inventors: Karoly Nikolics, Keith C. McFarland, Deborah L. Segaloff, Peter H. Seeburg
  • Luteinizing hormone/choriogonadotropin (LH/CG) receptor
    Patent number: 6261800
    Abstract: The invention relates to the purification, and cloning of receptors for the luteinizing hormone, choriogonadotropin, follicle stimulating hormone, and thyroid stimulating hormone. The invention additionally concerns the uses for such molecules in the diagnosis and therapy of human conditions.
    Type: Grant
    Filed: March 7, 1994
    Date of Patent: July 17, 2001
    Assignee: Genentech, Inc.
    Inventors: Karoly Nikolics, Keith C. McFarland, Deborah L. Segaloff, Peter H. Seeburg
  • Nucleic acid encoding the mature .beta..sub.B chain of inhibin and method for synthesizing polypeptides using such nucleic acid
    Patent number: 5716810
    Abstract: DNA encoding the prepro inhibin .alpha. and .beta. chains has been isolated. This DNA is ligated into expression vectors and used to transform host cells for the preparation of inhibin or activin. Also provided are prohormone domains and other inhibin .alpha. or .beta. chain derivatives having therapeutic or diagnostic interest. The compositions provided herein are useful in the manipulation of fertility in animals.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: February 10, 1998
    Assignee: Genentech, Inc.
    Inventors: Anthony J. Mason, Peter H. Seeburg
  • Nucleic acid encoding the mature .beta..sub.A chain of inhibin and method for synthesizing polypeptides using such nucleic acid
    Patent number: 5665568
    Abstract: DNA encoding the prepro inhibin .alpha. and .beta. chains has been isolated. This DNA is ligated into expression vectors and used to transform host cells for the preparation of inhibin or activin. Also provided are prohormone domains and other inhibin .alpha. or .beta. chain derivatives having therapeutic or diagnostic interest. The compositions provided herein are useful in the manipulation of fertility in animals.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: September 9, 1997
    Assignee: Genentech, Inc.
    Inventors: Anthony J. Mason, Peter H. Seeburg
  • Nucleic acid encoding the mature .alpha. chain of inhibin and method for synthesizing polypeptides using such nucleic acid
    Patent number: 5525488
    Abstract: DNA encoding the prepro inhibin .alpha. and .beta. chains has been isolated. This DNA is ligated into expression vectors and used to transform host cells for the preparation of inhibin or activin. Also provided are prohormone domains and other inhibin .alpha. or .beta. chain derivatives having therapeutic or diagnostic interest. The compositions provided herein are useful in the manipulation of fertility in animals.
    Type: Grant
    Filed: February 17, 1994
    Date of Patent: June 11, 1996
    Assignee: Genentech, Inc.
    Inventors: Anthony J. Mason, Peter H. Seeburg
  • DNA for expression of bovine growth hormone
    Patent number: 5489529
    Abstract: High-level expression of bovine growth hormone is achieved using DNA encoding bovine growth hormone which, when transcribed, produces messenger RNA (mRNA) that at its 5' end is substantially free of secondary structure that is capable of interfering with translation of the mRNA.
    Type: Grant
    Filed: July 19, 1993
    Date of Patent: February 6, 1996
    Inventors: Herman A. de Boer, Herbert L. Heyneker, Peter H. Seeburg
  • Nucleic acid encoding the .alpha. chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid
    Patent number: 5310661
    Abstract: DNA encoding the prepro inhibin .alpha. and .beta. chains has been isolated. This DNA is ligated into expression vectors and used to transform host cells for the preparation of inhibin or activin. Also provided are prohormone domains and other inhibin .alpha. or .beta. chain derivatives having therapeutic or diagnostic interest. The compositions provided herein are useful in the manipulation of fertility in animals.
    Type: Grant
    Filed: October 8, 1992
    Date of Patent: May 10, 1994
    Assignee: Genentech, Inc.
    Inventors: Anthony J. Mason, Peter H. Seeburg
  • Methods and products for facile microbial expression of DNA sequences
    Patent number: 5260201
    Abstract: Expression levels of polypeptides in recombinant host cell culture are increased by the use of synthetic DNA sequences chosen so that the mRNA transcribed therefrom is free of secondary structure sufficient to interfere with the efficiency of mRNA translation.
    Type: Grant
    Filed: November 28, 1990
    Date of Patent: November 9, 1993
    Assignee: Genentech, Inc.
    Inventors: Herman A. de Boer, Herbert L. Heynerer, Peter H. Seeburg
  • Method for expression of bovine growth hormone
    Patent number: 5254463
    Abstract: Microbial expression of an exogenous polypeptide may be inefficient if the messenger RNA has secondary structure (due to complementarity of spaced regions of the molecule) which impedes interaction with a ribosome. The occurrence of such structure can be predicted. The degeneracy of the genetic code gives freedom to alter the nucleic acid composition of the CDNA to eliminate harmful secondary structure of the MRNA.For example, bovine growth hormone (BGH) is poorly expressed by E. coli transformed with a recombinant plasmid containing the natural BGH gene. The corresponding MRNA has complementary regions at 46-51 and 73-78. Therefore a plasmid PBGH 33-4 was constructed containing a BGH gene whose upstream portion was synthesized (making use of plasmid PHGH 207-1 which contains an efficiently expressible gene for the closely related human growth hormone) so as not to cause the troublesome complementarity. E. coli transformed therewith produced BGH with-a yield of better than 10.sup.5 copies per cell.
    Type: Grant
    Filed: September 12, 1990
    Date of Patent: October 19, 1993
    Assignee: Genentech, Inc.
    Inventors: Herman A. de Boer, Herbert L. Heyneker, Peter H. Seeburg
  • Nucleic acid encoding the ba chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid
    Patent number: 5215893
    Abstract: DNA encoding the prepro inhibin .alpha. and .beta. chains has been isolated. This DNA is ligated into expression vectors and used to transform host cells for the preparation of inhibin or activin. Also provided are prohormone domains and other inhibin .alpha. and .beta. chain derivatives having therapeutic or diagnostic interest. The compositions provided herein are useful in the manipulation of fertility in animals.
    Type: Grant
    Filed: August 12, 1991
    Date of Patent: June 1, 1993
    Assignee: Genentech, Inc.
    Inventors: Anthony J. Mason, Peter H. Seeburg
  • Nucleic acid encoding .beta. chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid
    Patent number: 5089396
    Abstract: DNA encoding the prepro inhibin .alpha. and .beta. chains has been isolated. This DNA is ligated into expression vectors and used to transform host cells for the preparation of inhibin or activin. Also provided are prohormone domains and other inhibin .alpha. and .beta. chain derivatives having therapeutic or diagnostic interest. The compositions provided herein are useful in the manipulation of fertility in animals.
    Type: Grant
    Filed: July 5, 1988
    Date of Patent: February 18, 1992
    Assignee: Genentech, Inc.
    Inventors: Anthony J. Mason, Peter H. Seeburg
  • Prepro-LHRH C-terminal peptide DNA
    Patent number: 5075224
    Abstract: DNA encoding a novel polypeptide hormone, designated CTP, has been identified in the human genome. CTP is expressed as a fusion protein (proLHRH) with luteinizing hormone releasing hormone (LHRH), and is post-translationally processed to CTP and LHRH. CTP, its derivatives, and its fusions, including proLHRH, are useful in therapy and diagnostics.
    Type: Grant
    Filed: April 2, 1991
    Date of Patent: December 24, 1991
    Assignee: Genentech, Inc.
    Inventors: Peter H. Seeburg, John P. Adelman
  • Terminal methionyl bovine growth hormone and its use
    Patent number: 4880910
    Abstract: Novel amino terminal methionyl embodiments of bovine growth hormone are prepared in recombinant cell culture. Amino terminal methionyl derivatives of bovine growth hormone are particularly useful in enhancing milk production by dairy cattle.
    Type: Grant
    Filed: June 8, 1984
    Date of Patent: November 14, 1989
    Assignee: Genentech, Inc.
    Inventors: Herman A. de Boer, Herbert L. Heynerer, Peter H. Seeburg
  • Compositions of hormonally active human and porcine inhibin containing an .alpha. chain and 62 chain
    Patent number: 4798885
    Abstract: DNA encoding the prepro inhibin .alpha. and .beta. chains has been isolated. This DNA is ligated into expression vectors and used to transform host cells for the preparation of inhibin or activin. Also provided are prohormone domains and other inhibin .alpha. or .beta. chain derivatives having therapeutic or diagnostic interest. The compositions provided herein are useful in the manipulation of fertility in animals.
    Type: Grant
    Filed: December 31, 1986
    Date of Patent: January 17, 1989
    Assignee: Genentech, Inc.
    Inventors: Anthony J. Mason, Peter H. Seeburg
  • DNA vectors encoding a novel human growth hormone-variant protein
    Patent number: 4670393
    Abstract: A novel non-allelic human growth hormone variant encoding gene is isolated using recombinant DNA techniques. The human growth hormone variant gene or a human growth hormone variant gene fused to a presequence may be inserted into cloning or expression vehicles which in turn may be used to transform cells in culture.
    Type: Grant
    Filed: March 1, 1984
    Date of Patent: June 2, 1987
    Assignee: GENENTECH, Inc.
    Inventor: Peter H. Seeburg
  • Novel human growth hormone like protein HGH-V encoded in the human genome
    Patent number: 4665160
    Abstract: A novel non-allelic human growth hormone variant protein is disclosed. The structure of the protein is determined and the protein product is produced by recombinant DNA methods.
    Type: Grant
    Filed: March 1, 1984
    Date of Patent: May 12, 1987
    Assignee: Genentech, Inc.
    Inventor: Peter H. Seeburg
  • Microorganism containing gene for human chorionic somatomammotropin
    Patent number: 4447538
    Abstract: A microorganism containing a recombinant DNA transfer vector having the coding sequences for human chorionic somatomammotropin.
    Type: Grant
    Filed: February 5, 1982
    Date of Patent: May 8, 1984
    Assignee: Regents of the University of California
    Inventors: Howard M. Goodman, John Shine, Peter H. Seeburg
  • Method for cloning human growth hormone varient genes
    Patent number: 4446235
    Abstract: A novel non-allelic human growth hormone variant is disclosed. It is prepared by a new method of obtaining cDNA from the genomic sequences of a eukaryotic organism.
    Type: Grant
    Filed: March 22, 1982
    Date of Patent: May 1, 1984
    Assignee: Genentech, Inc.
    Inventor: Peter H. Seeburg
  • Purification of nucleotide sequences suitable for expression in bacteria
    Patent number: 4407948
    Abstract: A method for purifying a DNA fragment of specific desired nucleotide sequence containing a restriction site, from a population of DNA molecules homogeneous in length by endonuclease cleavage and fractionation.
    Type: Grant
    Filed: February 5, 1982
    Date of Patent: October 4, 1983
    Assignee: The Regents of the University of California
    Inventors: Howard M. Goodman, John Shine, Peter H. Seeburg
  • Recombinant DNA transfer vectors
    Patent number: 4363877
    Abstract: Recombinant DNA transfer vectors containing codons for human somatomammotropin and for human growth hormone.
    Type: Grant
    Filed: April 19, 1978
    Date of Patent: December 14, 1982
    Assignee: The Regents of the University of California
    Inventors: Howard M. Goodman, John Shine, Peter H. Seeburg