Abstract: Methods for forming a sequence encoded oligomer includes oligomerizing first and second antibody-oligonucleotide conjugates through hybridization using at least one template oligo nucleotide. The first antibody-oligonucleotide conjugate comprises an oligonucleotide strand comprising a first sequence and a second sequence joined by an alkyne. The second antibody-oligonucleotide conjugate comprises an oligonucleotide strand comprising a third sequence and a fourth sequence joined by an alkyne.

Abstract: The present disclosure provides compositions comprising protein crystals and methods for programmable biomaterial synthesis. The methods of the disclosure provide the ability to organize proteins within protein crystals with control over protein orientation.