Abstract: The present invention relates to the use of (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid of formula (I), prefer-ably in form of one of its salts or solvates or hydrates, preferably (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid in form of monohydrate (I) of formula (I-M-I) or (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)-ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid inform of mono hydrate (II) of formula (I-M-II), in the inhalative treatment of cardiopulmonary and pulmonary disorders, such as pulmonary arterial hypertension (P AH), chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary hypertension (PH) associated with chronic lung disease (PH group 3) such as pulmonary hypertension in chronic obstructive pulmo

Abstract: A hybrid drive unit includes an internal combustion engine, electric machine, and transmission having an input shaft and first and second countershafts. The internal combustion engine is directly couplable via a clutch to the input shaft. There are six shiftable gear pairings, each with a gearwheel arranged coaxially to the input shaft. The first gear pairing has a first gearwheel as an idler gear arranged coaxially to the input shaft and a second gearwheel as an idler gear arranged coaxially to the first countershaft. The electric machine is connected to the first gear pairing so that torques are directable into the transmission via the first gear pairing.

Abstract: A hybrid transmission for a vehicle includes a transmission input shaft extending in a transverse direction, at least one countershaft arranged parallel to the transmission input shaft, a clutch device arranged coaxially with respect to the transmission input shaft and which has at least one clutch, and a differential having a differential input gear. A rotational axis of the differential input gear is arranged parallel to the transmission input shaft. The transmission also includes an electric machine having a rotor with a rotor rotational axis arranged parallel to the transmission input shaft and a transmission control device. As viewed in a longitudinal direction perpendicular to the transverse direction, the differential input gear, the transmission input shaft, and a transmission controller including the transmission control device are arranged in succession in the sequence specified.

Abstract: A hybrid transmission for a vehicle includes a transmission input shaft extending in a transverse direction, at least one countershaft arranged parallel to the transmission input shaft, a clutch device arranged coaxially with respect to the transmission input shaft and which has at least one clutch, and a differential having a differential input gear. A rotational axis of the differential input gear is arranged parallel to the transmission input shaft. The transmission also includes an electric machine having a rotor with a rotor rotational axis arranged parallel to the transmission input shaft and a transmission control device. As viewed in a longitudinal direction perpendicular to the transverse direction, the differential input gear, the transmission input shaft, and a transmission controller including the transmission control device are arranged in succession in the sequence specified.

Abstract: According to one aspect of the presently disclosed subject there is provided a computerized method for scoring performance of a move of a trainee in a trainee frame input in relation to a move of a trainer in a trainer video wherein the trainer move includes at least one trainer keyframe. The method comprising obtaining a trainee frame input comprising a trainee move, the trainee move comprising a plurality of trainee frames, based on the at least one trainer keyframe, processing the plurality of trainee frames to provide a move performance score, indicative of the performance of the trainee move in relation to the trainer move, with respect to at least one aspect of the performance. In some examples, the aspects can be one of a similarity aspect, a timing aspect, or a motion dynamics aspect or a combination thereof.

Abstract: A hybrid transmission for a vehicle includes a transmission input shaft extending in a transverse direction, at least one countershaft arranged parallel to the transmission input shaft, a clutch device arranged coaxially with respect to the transmission input shaft and which has at least one clutch, and a differential having a differential input gear. A rotational axis of the differential input gear is arranged parallel to the transmission input shaft. The transmission also includes an electric machine having a rotor with a rotor rotational axis arranged parallel to the transmission input shaft and a transmission control device. As viewed in a longitudinal direction perpendicular to the transverse direction, the differential input gear, the transmission input shaft, and a transmission controller including the transmission control device are arranged in succession in the sequence specified.

Abstract: A hybrid transmission for a vehicle includes a transmission input shaft extending in a transverse direction, at least one countershaft arranged parallel to the transmission input shaft, a clutch device arranged coaxially with respect to the transmission input shaft and which has at least one clutch, and a differential having a differential input gear. A rotational axis of the differential input gear is arranged parallel to the transmission input shaft. The transmission also includes an electric machine having a rotor with a rotor rotational axis arranged parallel to the transmission input shaft and a transmission control device. As viewed in a longitudinal direction perpendicular to the transverse direction, the differential input gear, the transmission input shaft, and a transmission controller including the transmission control device are arranged in succession in the sequence specified.

Abstract: A hybrid drive unit includes a transmission having an input shaft and first and second countershafts. An internal combustion engine is directly couplable to the input shaft via a clutch. There are seven shiftable gear pairings, each including a gearwheel arranged coaxially to the input shaft. The first gear pairing has a first gearwheel formed as an idler gear and arranged coaxially to the input shaft, and a second gearwheel formed as an idler gear and arranged coaxially to the first countershaft. The electric machine is connected to the first gear pairing such that torques are transmittable from the electric machine to the transmission via the first gear pairing.

Abstract: A dual-clutch transmission includes first and second partial transmissions, a first countershaft to which a first output gear is permanently connected in a rotationally fixed manner, and a second countershaft to which a second output gear is permanently connected in a rotationally fixed manner. A first idler assigned to the first partial transmission and a second idler assigned to the second partial transmission are respectively arranged coaxially to the first countershaft and are couplable to each other in a rotationally fixed manner by a bridge switching element. The first partial transmission includes exactly three single-gear planes, including a first single-gear plane, second single-gear plane having the first idler, and third single-gear plane.

Abstract: A dual-clutch transmission includes two clutches for respectively connecting an input shaft in a rotationally fixed manner to a sub-transmission input shaft. Two layshafts each have one output gear arranged coaxially with respect thereto. A first, second, and third forward idler gear are each arranged coaxially with respect to the one layshaft. A fourth and fifth forward idler gear are each arranged coaxially with respect to the other layshaft. One of the output gears is a larger output gear having a greater diameter or a greater number of teeth than the other, smaller output gear. The first forward idler gear forms a second gear stage, the second forward idler gear forms a third gear stage, etc. The gear stages have a decreasing transmission ratio in the order stated.

Abstract: An electrical connection structure for connecting a piezoelectric element and an electrical circuit to each other with a conductive adhesive is described. The electrical connection structure includes an epoxy, a conductive component surrounded by the epoxy, and a trace feature implemented on top of the electrical connection structure. At least one depression feature can be implemented on top of the electrical connection structure to constrain the epoxy and the at least one conductive component.

Abstract: A hybrid transmission for a vehicle includes a transmission input shaft extending in a transverse direction, at least one countershaft arranged parallel to the transmission input shaft, a clutch device arranged coaxially with respect to the transmission input shaft and which has at least one clutch, and a differential having a differential input gear. A rotational axis of the differential input gear is arranged parallel to the transmission input shaft. The transmission also includes an electric machine having a rotor with a rotor rotational axis arranged parallel to the transmission input shaft and a transmission control device. As viewed in a longitudinal direction perpendicular to the transverse direction, the differential input gear, the transmission input shaft, and a transmission controller including the transmission control device are arranged in succession in the sequence specified.

Abstract: A hybrid transmission for a vehicle includes a transmission input shaft extending in a transverse direction, at least one countershaft arranged parallel to the transmission input shaft, a clutch device arranged coaxially with respect to the transmission input shaft and which has at least one clutch, and a differential having a differential input gear. A rotational axis of the differential input gear is arranged parallel to the transmission input shaft. The transmission also includes an electric machine having a rotor with a rotor rotational axis arranged parallel to the transmission input shaft and a transmission control device. As viewed in a longitudinal direction perpendicular to the transverse direction, the differential input gear, the transmission input shaft, and a transmission controller including the transmission control device are arranged in succession in the sequence specified.

Abstract: A multi-layer piezoelectric microactuator assembly has at least one poled and active piezoelectric layer and one poled but inactive piezoelectric layer. The poled but inactive layer acts as a constraining layer in resisting expansion or contract of the first piezoelectric layer thereby reducing or eliminating bending of the assembly as installed in an environment, thereby increasing the effective stroke length of the assembly. Poling only a single layer would induce stresses into the device; hence, polling both piezoelectric layers even though only one layer will be active in use reduces stresses in the device and therefore increases reliability.

Abstract: A dual clutch transmission includes an input shaft and a first clutch, which has a first input disc carrier, a first output disc carrier, a first force transfer region, and a first actuating piston. The transmission has a second clutch having a second input disc carrier, a second output disc carrier, a second force transfer region, and a second actuating piston. The transmission includes a first partial transmission having a first partial transmission input shaft, and a second partial transmission having a second partial transmission input shaft. The input shaft, the first input disc carrier, and the second input disc carrier are non-rotationally connected to one another. The first output disc carrier is non-rotationally connected to the first partial transmission input shaft. The second output disc carrier is non-rotationally connected to the second partial transmission input shaft.

Abstract: The present invention relates to a biocompatible device which comprises on its surface an adsorbed layer of a polymer P which is a copolymer of at least one macromonomer selected from an ester E of (meth)acrylic acid and polyethylene oxide or a polyethylene glycol (meth)acrylamide, at least one monomer M selected from alkyl (meth)acrylate, aryloxyalkyl (meth)acrylate, alkyl (meth)acrylamide or aryl (meth)acrylamide, and at least one cationic monomer C selected from cationic ethylenically unsaturated N-containing monomers. It further relates to a process for making a biocompatible device which comprises on its surface an adsorbed layer of the polymer P comprising the following steps: providing a biocompatible device, and applying to the surface of the biocompatible device a solution S of the polymer Pin a solvent L.

Abstract: A dual clutch transmission includes an input shaft having a first clutch having a first input disc carrier, a first output disc carrier, a first force transfer region, and a first actuation piston. The transmission includes a second clutch having a second input disc carrier, a second output disc carrier, a second force transfer region, and a second actuation piston. A first sub-transmission includes a first sub-transmission input shaft and a second sub-transmission has a second sub-transmission input shaft. The input shaft, the first input disc carrier, and the second input disc carrier are connected to one another for fixedly conjoint rotation. The first output disc carrier is connected to the first sub-transmission input shaft for fixedly conjoint rotation. The second output disc carrier is connected to the second sub-transmission input shaft for fixedly conjoint rotation. The second sub-transmission input shaft is arranged coaxially with and radially surrounding the first sub-transmission input shaft.

Abstract: The present invention relates generally to the field of pharmaceuticals, and specifically relates to isofagomine (IFG), novel salts thereof and preparation methods and uses of these, for example, in formulating pharmaceutical compositions for the treatment of Gaucher disease. Also provided are novel crystalline forms of isofagomine salts, methods for preparing the crystalline forms, and their use in formulating pharmaceutical compositions.

Abstract: A dual clutch transmission includes an input shaft having a first clutch having a first input disc carrier, a first output disc carrier, a first force transfer region, and a first actuation piston. The transmission includes a second clutch having a second input disc carrier, a second output disc carrier, a second force transfer region, and a second actuation piston. A first sub-transmission includes a first sub-transmission input shaft and a second sub-transmission has a second sub-transmission input shaft. The input shaft, the first input disc carrier, and the second input disc carrier are connected to one another for fixedly conjoint rotation. The first output disc carrier is connected to the first sub-transmission input shaft for fixedly conjoint rotation. The second output disc carrier is connected to the second sub-transmission input shaft for fixedly conjoint rotation. The second sub-transmission input shaft is arranged coaxially with and radially surrounding the first sub-transmission input shaft.

Abstract: A dual clutch transmission includes an input shaft, a first clutch having a first input disc carrier, a first output disc carrier, a first force transfer region and a first actuation piston. The transmission also includes a second clutch having a second input disc carrier, a second output disc carrier, a second force transfer region, and a second actuation piston. The transmission includes a first sub-transmission having a first sub-transmission input shaft, and a second sub-transmission having a second sub-transmission input shaft. The input shaft, the first input disc carrier, and the second input disc carrier are connected to one another for conjoint rotation. The first output disc carrier is connected to the first sub-transmission input shaft for conjoint rotation. The second output disc carrier is connected to the second sub-transmission input shaft for conjoint rotation. The second sub-transmission input shaft is arranged coaxially with and radially surrounding the first sub-transmission input shaft.