Abstract: Provided are compositions, methods, and kits relating to the detection of a circulating or soluble form of the EphA2 receptor tyrosine kinase.

Abstract: Provided are compositions, methods, and kits relating to the detection of a circulating or soluble form of the KET receptor tyrosine kinase.

Abstract: A method of storing information relating to the transmission of messages by an entity over a given time period comprises the step of creating a signature comprising a plurality of parameters related to the transmission of messages over that time period wherein the parameters comprise at least one parameter related to the transmission of messages over a portion of the period and also related to the position of the portion in the period, to enable output data to be derived from the stored information. The signature may be updated by a weighted averaging process with other more recent signatures. Application in fraud detection where signature representing information in many call detail records from a particular subscriber is fed to a neural network.

Abstract: The present invention describes clinically and medically important methods of examining, screening over time, and monitoring the outcome of a cancer patient who is undergoing treatment or therapy for his or her disease. More specifically, the invention provides a method of monitoring the progression of disease, or the effectiveness of cancer treatment, in a cancer patient by measuring the levels of one or more analytes of the plasminogen activator (uPA) system, namely, uPA, PAI-1 and the complex of uPA:PAI-1, in a sample taken from the cancer patient, preferably, before treatment, at the start of treatment, and at various time intervals during treatment. As a result of performing the method, an increase or elevation in the levels of one or more of the PA system analytes in the cancer patient compared with the levels one or more of the respective PA system analytes in normal control individuals serves as an indicator of cancer advancement or progression and/or a lack of treatment effectiveness for the patient.

Abstract: Admission of rapidly varying traffic flows to a communications network is controlled by sampling the traffic flows each at an ingress, and sampling an aggregate flow of said flows at some or all of the resources used by the aggregate flow. From this sampling, a mean bandwidth requirement for each traffic flow and a measure of the variance from that mean are determined. First and second prices for the mean and variance components of the controlled traffic flows that are calculated. These price calculations are used to determine an admission cost for each said flow so as to regulate the admission of that flow via a feedback price mechanism.

Abstract: A communications network has multiple resource-allocation layers and incorporates a management structure for allocating resources to allocate resources requested by a first layer of said layers from a second of said layers. At a first layer, the management structure provides an indication to a second layer of the required resources that are to be allocated from the second layer. The second layer automatically offers the required resource together with a condition for use of those resources. This condition includes a notional price factor which is dependent on current demand. Under the control of the manager, the first layer determines if the condition for use of the offered resources is acceptable and, if so, automatically accepts the offered resources from the second layer. In a preferred embodiment, ingress to an underlying multi-wavelength transport layer of the network is controlled via a virtual port which allocates traffic to real ports one for each wavelength supported by the transport layer.

Abstract: The present invention is directed to the detection and quantification of total PDGFR-? in body fluids, particularly serial changes of total PDGFR-? levels in a subject's body fluids. Further, the invention is directed to detecting and quantitatiing total PDGFR-? in conjunction with one or more other proteins, such as, oncoproteins, angiogenic factors, tumor markers, inhibitors, growth factor receptors, metastasis proteins, and tumor suppressors. The disclosed methods are diagnostic/prognostic for diseases, and useful to select therapies for patients with diseases, preferably preneoplastic/neoplastic diseases. The disclosed methods are particularly useful to monitor the status of a patient's disease, and/or to monitor how a patient is responding to a therapy.

Abstract: Congestion control in a communications network, e.g. an Internet Protocol (IP) network, is effected by controlling the egress rate of traffic from the output buffer of the system routers or switches. The traffic egressing from an output buffer is sampled at sequential intervals to determine a bit rate at each interval. An autocorrelation function is calculated from these samples and is used to provide an estimated statistical measure or parameter indicative of congestion and related to a long range dependence of the traffic. A calculation is then made as to whether an increase or a decrease in the buffer output rate would result in a decrease in the congestion parameter, and the buffer output rate is adjusted accordingly.

Abstract: Congestion control in a communications network, e.g. an Internet Protocol (IP) network, is effected by controlling the egress rate of traffic from the output buffer of the system routers or switches. The traffic egressing from an output buffer is sampled at sequential intervals to determine a bit rate at each interval. An autocorrelation function is calculated from these samples and is used to provide an estimated statistical measure or parameter indicative of congestion and related to a long range dependence of the traffic. A calculation is then made as to whether an increase or a decrease in the buffer output rate would result in a decrease in the congestion parameter, and the buffer output rate is adjusted accordingly.

Abstract: A method of storing information relating to the transmission of messages by an entity over a given time period comprises the step of

Abstract: Admission of rapidly varying traffic flows to a communications network is controlled by sampling the traffic flows each at an ingress, and sampling an aggregate flow of said flows at some or all of the resources used by the aggregate flow. From this sampling, a mean bandwidth requirement for each traffic flow and a measure of the variance from that mean are determined. First and second prices for the mean and variance components of the controlled traffic flows that are calculated. These price calculations are used to determine an admission cost for each said flow so as to regulate the admission of that flow via a feedback price mechanism.

Abstract: A communications network has multiple resource-allocation layers and incorporates a management structure for allocating resources to allocate resources requested by a first layer of said layers from a second of said layers. At a first layer, the management structure provides an indication to a second layer of the required resources that are to be allocated from the second layer. The second layer automatically offers the required resource together with a condition for use of those resources. This condition includes a notional price factor which is dependent on current demand. Under the control of the manager, the first layer determines if the condition for use of the offered resources is acceptable and, if so, automatically accepts the offered resources from the second layer. In a preferred embodiment, ingress to an underlying multi-wavelength transport layer of the network is controlled via a virtual port which allocates traffic to real ports one for each wavelength supported by the transport layer.

Abstract: A method of predicting at least one future value of a time series of data using a neural network comprising the steps of:(I) inputting a plurality of values of the time series into the neural network;(ii) inputting information about a time into the neural network; and(iii) obtaining outputs from the neural network said outputs comprising predicted future value(s) of the time series.

Abstract: A method of managing the processing of information using a first neural network, the information relating to the transmission of messages in a telecommunications network, uses the steps of:(i) monitoring the performance of the first neural network in processing the information;(ii) creating a second neural network of the same topology as the first when a predetermined performance threshold is reached, and(iii) retraining the second neural network while continuing to process the information using the first neural network. If the neural networks are implemented using objects, such retraining can be facilitated by using a persistance mechanism to enable the objects to be stored and moved. Applications in fraud detection.

Abstract: A generic anomaly detection engine is described which provides neural network technology to process information such as call detail records and detect anomalies in the information, such as mobile phone fraud. Information from call detail records is pre-processed to form signatures which represent the calling behavior of a subscriber. These signatures are formed in one of a plurality of predetermined formats. The generic anomaly detection engine is instantiated in order to create an anomaly detector which is suitable for a particular situation and during the instantiation process the topology of the neural network components is automatically adjusted to fit the required situation. The topology is adjusted to according to the format of the signatures.

Abstract: Brassiere made of elastic material, the cup assembly of which is constructed, around the two cups, at least with shoulder straps and side panels which merge into a back panel. The shoulder straps and/or the side panels are of broadened design. The brassiere is provided, on the side next to the body, with a complete lining accessible for compression pads, or is provided, on the side next to the body with lining pockets (5) in selected positions, in which compression pads (10) of resilient material can be removably accommodated. At least one lining pocket for accommodating a compression pad (11) can also be provided in the cups of the cup assembly and/or in the back panel. The compression pad is composed of a thin strip of resilient material, such as foam rubber, and has chamfered edges. The strip can be covered with seam-free material, or is accommodated in lining pockets of thin seam-free material, and has, for example, a thickness of at least 1 cm.