Abstract: The present disclosure relates to compounds that are capable of penetrating the blood brain barrier to modulate the activity of EGFR tyrosine kinase. The disclosure further relates to methods of treating glioblastoma and other EGFR-mediated cancers, such as those that have been determined to have altered glucose metabolism in the presence of inhibitors. The present disclosure also provides methods of administering to a subject a glucose metabolism inhibitor and a cytoplasmic p53 stabilizer.

Abstract: Techniques for customizing knowledge representation systems including identifying, based on a plurality of concepts in a knowledge representation (KR), a group of one or more concepts relevant to user context information, and providing the identified group of one more concepts to a user. The KR may include a combination of modules. The modules may include a kernel and a customized module customized for the user. The kernel may accessible via a second KR.

Abstract: Systems, methods, and devices allow intravascular or percutaneous mapping, orientation and/or ablation, in bodily cavities or lumens. A device includes elongate members, moveable between an unexpanded configuration and an expanded or fanned configuration. The elongate members form a stack in the unexpanded configuration to fit through a catheter sheath. The elongate members follow respective arcuate or curvilinear paths as advanced from the sheath into the bent or coiled stack configuration, adopting volute, scroll or rho shapes, and may be nested. The elongated members are fanned or radially spaced circumferentially with respect to one another into the expanded or fanned configuration. Transducer elements carried by elongate members sense various physiological characteristics of or proximate tissue, and/or may apply energy to or proximate tissue. The elongate members are rotatable in groups or as a group in the expanded configuration. The device is retractable.

Abstract: Systems and methods for purifying precursor compounds are provided. A method comprises one or more of the following steps: mixing a crude product solution with a first solvent, wherein the crude product solution comprises a precursor compound and at least one impurity; wherein a boiling point of the first solvent is greater than a boiling point of the crude product solution; feeding a mixture of at least the crude product solution and the first solvent to an evaporator; and collecting, from the evaporator, a distillate comprising the precursor compound, wherein a purity of the precursor compound in the distillate is greater than 95% as determined by 1H NMR. Other methods and systems are provided herein.

Abstract: Provided are humanized anti-HLA-A2 antibodies. In certain aspects, the humanized anti-HLA-A2 antibodies are capable of constituting an antigen binding domain of a chimeric antigen receptor (CAR), where the CAR is capable of being expressed in a human cell such that the CAR specifically binds to HLA-A2. Also provided are CARs that include the humanized anti-HLA-A2 antibodies. Modified cells including the antibodies and CARs, as well as methods of using such modified cells are also provided.

Abstract: Implementations of semiconductor packages may include: a digital signal processor having a first side and a second side and an image sensor array, having a first side and a second side. The first side of the image sensor array may be coupled to the second side of the digital signal processor through a plurality of hybrid bond interconnect (HBI) bond pads and an edge seal. One or more openings may extend from the second side of the image sensor array into the second side of the digital signal processor to an etch stop layer in the second side of the digital signal processor. The one or more openings may form a second edge seal between the plurality of HBI bond pads and the edge of the digital signal processor.

Abstract: One or more computer-readable media store instructions that cause one or more processors to transmit a request for content, receive a first content item and a second content item associated with the first content item, and display the first content item within a content slot in an information resource. The content slot has a first size occupying a first region of the information resource. The operations further include identifying a user interaction associated with the first content item and, responsive to the user interaction, expanding the content slot from the first size to a second size and displaying, in the expanded content slot, the first content item, the second content item, and an actionable object configured to reduce the content slot from the second size to the first size. The second size occupies the first region and an adjoining second region of the information resource.

Abstract: Example systems and methods for analyzing and summarizing legal documents using artificial intelligence are disclosed. A system receives a legal document such as a contract or agreement, and utilizes multiple AI models in combination to process and summarize the document. This includes identifying the type of legal document using a natural language model, and then extracting key information like parties, dates, and monetary values. Related clauses within the document are consolidated using a clause consolidation algorithm even if they are not contiguous. Summaries are generated for each section of the document. Additionally, a question-answering module preemptively generates common questions and answers about the agreement to highlight key considerations for the parties involved. By leveraging an ensemble of customized AI models, the system aims to simplify comprehension of legal documents.

Abstract: An arrangement for actuating a shift element for a bottom bracket gearbox (1) includes a shift ring (4) rotatably mounted in a housing (3) and assigned to a gearbox component. A shift pawl (5) for locking or releasing the shift ring (4) is assigned to the shift ring (4) for shifting a gear stage. A support region mechanically reinforces the housing (3) and is provided at least along a contact region (14) between an inner wall (8) of the housing (3) and an outer circumference of the shift ring (4). The contact region (14) is defined by reaction forces (16) acting when the shift ring (4) is locked.

Abstract: A computer-implemented method of processing at least one image of a retina of an eye acquired by an ophthalmic imaging device, wherein the at least one image shows a texture of the retina. The method comprises processing a first image of the at least one image using a noise reduction algorithm based on machine learning to generate a de-noised image of the retina, wherein the texture of the retina shown in the first image is at least partially removed by the noise reduction algorithm to generate the de-noised image. The method further comprises combining a second image of the at least one image with the de-noised image to generate at least one hybrid image of the retina which shows more of the texture of the retina than the de-noised image.

Abstract: The invention is directed to a compound of formula (I) for use in organic electronic devices, an organic semiconductor layer comprising the compound of formula (I), an organic electronic device comprising the organic semiconductor layer, and a display device comprising the organic electronic device. Wherein R1, R2, R3 and R4 are independently selected from F, Cl, CN or CF3; R? is selected from formula (II); R? is selected from formula (III); R5 is selected from substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or CN; and the “*” denotes the binding position.

Abstract: A system and method for contact-based spatial frequency domain imaging. A medium to be imaged is contacted by a sheet comprising an array of lighting elements generating illumination light patterns illuminating the medium, and comprising an array of sensor elements measuring spatially resolved images of resulting light patterns reflected back after interaction of the illumination light patterns with the medium. The lighting elements generate illumination light patterns that are spatially modulated in light intensity along a surface of the illuminated medium according to a respective different spatial frequency. A set of spatially modulated images is determined based on the measured resulting light patterns caused by the different illumination light patterns. An image of the medium can be generated based on a combination of the spatially modulated images.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for controlling an agent interacting with an environment. In one aspect, a method comprises: receiving one or more observations of an environment; receiving an input text sequence that describes a task to be performed by a robot in the environment; generating an encoded representation of the input text sequence in an embedding space; generating a corresponding encoded representation of each of the one or more observations in the embedding space; generating a sequence of input tokens that comprises the encoded representation of the input text sequence and the corresponding encoded representation of each observation; processing the sequence of input tokens using a language model neural network to generate an output text sequence that comprises high-level natural language instructions; and determining, from the high-level natural language instructions, one or more actions to be performed by the robot.

Abstract: Disclosed herein is a composition including (i) at least one polyurethane (1) carrying ethylenically unsaturated groups and COOH groups, which COOH groups are at least partly in the form of a salt group thereof, which polyurethane is obtained by the reaction of at least one polyol (B1) carrying at least one COOH group, at least monoalcohol (B2) carrying at least one ethylenically unsaturated group, optionally at least polyol (B3) carrying at least one ethylenically unsaturated group and no COOH group, at least one polyol (B4) carrying no ethylenically unsaturated group and no COOH group, at least one polyisocyanate (A1) carrying at least one ethylenically unsaturated group, optionally at least one polyisocyanate (A2) carrying no ethylenically unsaturated group, and optionally at least one compound (C1) carrying at least one NH2 group and no OH group.

Abstract: An ankle stretch orthosis includes a foot assembly having a ball support assembly adjustably mounted on a foot plate. The foot assembly includes an adjustment mechanism for selectively adjusting a position of ball support assembly relative to the foot plate to align the ball support assembly with a ball portion of a foot that is one of supinated and pronated.

Abstract: A vertical power semiconductor device includes a silicon carbide (SiC) semiconductor body having opposite first and second surfaces. The SiC semiconductor body includes a transistor cell area including gate structures, a gate pad area, and an interconnection area electrically coupling a gate electrode of the gate structures and a gate pad of the gate pad area via a gate interconnection. The vertical power semiconductor device further includes a sensor electrode and a first interlayer dielectric having a first interface to the sensor electrode and a second interface to at least one of the gate electrode or the gate interconnection. A conduction band offset at the first interface ranges from 1 eV to 2.5 eV. The vertical power semiconductor device further includes a second interface to at least one of the gate electrode or the gate interconnection. The second interlayer dielectric laterally adjoins to the first interlayer dielectric.

Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a user equipment (UE) may transmit an indication of a set of frequency bands supported for uplink transmission switching between frequency bands, the frequency bands including one or more bandwidth parts. The UE may transmit an indication of a subset of the set of frequency bands, the subset supported for dynamic uplink transmission switching between the frequency bands. The UE may transmit one or more uplink communications via one or more frequency bands of the subset of the set of frequency bands. Numerous other aspects are described.

Abstract: An ingestible device (200), comprising: a housing (210, 220) comprising a stop geometry (228) at an exit hole (224); a tissue penetrating member (230) and an actuator that comprises: a pushing portion (260) configured for axial movement from a first to a second position, the pushing portion configured to move the tissue penetrating member from within the housing to a lodged position in tissue, and a holder portion (270) coupled with the pushing portion (260) for initial axial movement with the pushing portion. In the first position the holder portion releasably holds the tissue penetrating member (230) in axial retaining engagement. As the pushing portion (260) moves towards the second position, the tissue penetrating member (230) moves through the exit hole (224) until the holder portion (270) enters into engagement with the stop geometry (228). The pushing portion (260) moves further to release and advance the tissue penetrating member (230).

Abstract: A method is described for performing a wipe-out and verification of a plurality of non-volatile memory (NVM) cells. The method includes performing an operation to set all the plurality of NVM cells to a single state. The single state may be one of a conducing or non-conducting state depending on the NVM architecture. After the operation to set the cells to the single state is complete, the verification is performed. In the verification operation, all cells of the plurality of NVM cells are set to the single state by performing a single read operation on the plurality of NVM cells. Detection of one of a conducting or non-conducting path through the plurality of NVM cells is used to verify if all cells of the NVM array had their contents wiped out. A notification is provided in response to all cells not being set to the single known state.

Abstract: Systems and methods for a chatbot authentication system and process that may utilize a large language model (LLM) and state of the art generative natural language processing (NLP) to generate and/or interpret user answers questions generated based on comprehensive known data about the user. The questions can include skills-based and/or knowledge-based queries which may be open ended questions. The user answers provided may be evaluated for accuracy and completeness. Iterative and/or follow-up questions may be generated and posed to allow the user to provide clarifications or additional details. By virtue of the LLM and NLP, the systems and methods disclosed herein may understand the semantical meaning of the answers provided by the user, which can enable a more accurate, user friendly and secure authentication process.