Abstract: The present invention is based on the discovery of polyclonal IgG's ability to promote Schwann cell maturation, differentiation, and myelin production. Methods for treating non-idiopathic, demyelinating peripheral neuropathies in mammals, where the neuropathy is not immune-mediated or infection-mediated, through the administration of polyclonal IgG are provided. Types of demyelinating peripheral neuropathies treatable with the present invention include peripheral nerve trauma and toxin-induced peripheral neuropathies. Alternatively, a composition of polyclonal IgGs can be applied directly to a peripheral nerve cell to induce maturation, differentiation into a myelinating state, and myelin expression or promote cell survival.

Abstract: The present invention is based on the discovery of polyclonal IgG's ability to promote Schwann cell maturation, differentiation, and myelin production. Methods for treating non-idiopathic, demyelinating peripheral neuropathies in mammals, where the neuropathy is not immune-mediated or infection-mediated, through the administration of polyclonal IgG are provided. Types of demyelinating peripheral neuropathies treatable with the present invention include peripheral nerve trauma and toxin-induced peripheral neuropathies. Alternatively, a composition of polyclonal IgGs can be applied directly to a peripheral nerve cell to induce maturation, differentiation into a myelinating state, and myelin expression or promote cell survival.

Abstract: The present invention relates to methods of determining whether a patient responds to a therapeutic treatment of multiple sclerosis (MS), of monitoring the course of multiple sclerosis (MS) in a patient, of determining the risk for a relapse of multiple sclerosis (MS) in a patient, and of adjusting the dose of a therapeutic drug applied for therapeutic treatment of multiple sclerosis in a patient. Said methods are based on the determination of the level of at least one miRNA in a test sample isolated from the patient. The present invention also relates to a method of identifying a compound suitable for the treatment of multiple sclerosis in a patient.

Abstract: The present invention is based on the discovery of polyclonal IgG's ability to promote Schwann cell maturation, differentiation, and myelin production. Methods for treating non-idiopathic, demyelinating peripheral neuropathies in mammals, where the neuropathy is not immune-mediated or infection-mediated, through the administration of polyclonal IgG are provided. Types of demyelinating peripheral neuropathies treatable with the present invention include peripheral nerve trauma and toxin-induced peripheral neuropathies. Alternatively, a composition of polyclonal IgGs can be applied directly to a peripheral nerve cell to induce maturation, differentiation into a myelinating state, and myelin expression or promote cell survival.

Abstract: The present invention relates to methods of determining whether a patient responds to a therapeutic treatment of multiple sclerosis (MS), of monitoring the course of multiple sclerosis (MS) in a patient, of determining the risk for a relapse of multiple sclerosis (MS) in a patient, and of adjusting the dose of a therapeutic drug applied for therapeutic treatment of multiple sclerosis in a patient. Said methods are based on the determination of the level of at least one miRNA in a test sample isolated from the patient. The present invention also relates to a method of identifying a compound suitable for the treatment of multiple sclerosis in a patient.

Abstract: The present invention is based on the discovery of polyclonal IgG's ability to promote Schwann cell maturation, differentiation, and myelin production. Methods for treating non-idiopathic, demyelinating peripheral neuropathies in mammals, where the neuropathy is not immune-mediated or infection-mediated, through the administration of polyclonal IgG are provided. Types of demyelinating peripheral neuropathies treatable with the present invention include peripheral nerve trauma and toxin-induced peripheral neuropathies. Alternatively, a composition of polyclonal IgGs can be applied directly to a peripheral nerve cell to induce maturation, differentiation into a myelinating state, and myelin expression or promote cell survival.

Abstract: The present invention is based on the discovery of polyclonal IgG's ability to promote Schwann cell maturation, differentiation, and myelin production. Methods for treating non-idiopathic, demyelinating peripheral neuropathies in mammals, where the neuropathy is not immune-mediated or infection-mediated, through the administration of polyclonal IgG are provided. Types of demyelinating peripheral neuropathies treatable with the present invention include peripheral nerve trauma and toxin-induced peripheral neuropathies. Alternatively, a composition of polyclonal IgGs can be applied directly to a peripheral nerve cell to induce maturation, differentiation into a myelinating state, and myelin expression or promote cell survival.

Abstract: The present invention is based on the discovery of polyclonal IgG's ability to promote Schwann cell maturation, differentiation, and myelin production. Methods for treating non-idiopathic, demyelinating peripheral neuropathies in mammals, where the neuropathy is not immune-mediated or infection-mediated, through the administration of polyclonal IgG are provided. Types of demyelinating peripheral neuropathies treatable with the present invention include peripheral nerve trauma and toxin-induced peripheral neuropathies. Alternatively, a composition of polyclonal IgGs can be applied directly to a peripheral nerve cell to induce maturation, differentiation into a myelinating state, and myelin expression or promote cell survival.

Abstract: The present invention is based on the discovery of polyclonal IgG's ability to promote Schwann cell maturation, differentiation, and myelin production. Methods for treating non-idiopathic, demyelinating peripheral neuropathies in mammals, where the neuropathy is not immune-mediated or infection-mediated, through the administration of polyclonal IgG are provided. Types of demyelinating peripheral neuropathies treatable with the present invention include peripheral nerve trauma and toxin-induced peripheral neuropathies. Alternatively, a composition of polyclonal IgGs can be applied directly to a peripheral nerve cell to induce maturation, differentiation into a myelinating state, and myelin expression or promote cell survival.

Abstract: The present invention relates to methods of determining whether a patient responds to a therapeutic treatment of multiple sclerosis (MS), of monitoring the course of multiple sclerosis (MS) in a patient, of determining the risk for a relapse of multiple sclerosis (MS) in a patient, and of adjusting the dose of a therapeutic drug applied for therapeutic treatment of multiple sclerosis in a patient. Said methods are based on the determination of the level of at least one miRNA in a test sample isolated from the patient. The present invention also relates to a method of identifying a compound suitable for the treatment of multiple sclerosis in a patient.

Abstract: The invention relates to a side channel compressor, comprising a housing shell and a running wheel. The running wheel is mounted to be rotatable with respect to the housing shell to provide two annular sealing areas between the housing shell and the running wheel. The housing shell between the first and the second sealing area can be made of one piece. The gap dimensions of the first and second sealing areas can be adjusted by means of a disc spring/nut system or a wobble means. A fan impeller may be fixed on the motor shaft, and the housing shell can comprise cooling ribs, wherein the cooling ribs are arranged and formed such that the air conveyed by the fan impeller sweeps through the cooling ribs. One of the annular sealing areas can include a dead volume chamber. The housing shell may be a casting or a machined extruded profile.

Abstract: The invention relates to fan units for ventilators, in particular for CPAP-apparatus. The fan units comprise a housing, a motor having a stator and a rotor, with the stator being affixed to the housing, and an impeller affixed to the rotor. According to an embodiment the motor is positioned in the suction area of the impeller and the housing forms a suction channel extending helically about the motor axis and being arranged such that the sucked air is accelerated in the direction of rotation of the motor. According to another embodiment the housing in the proximity of the fixtures of the motor is formed such that the housing acts as spring element itself. According to another embodiment a tissue is provided in the fan unit through which the air flows after its compression by the impeller.

Abstract: The invention relates to a side channel compressor, comprising a housing shell and a running wheel. The running wheel is mounted to be rotatable with respect to the housing shell to provide two annular sealing areas between the housing shell and the running wheel. The housing shell between the first and the second sealing area can be made of one piece. The gap dimensions of the first and second sealing areas can be adjusted by means of a disc spring/nut system or a wobble means. A fan impeller may be fixed on the motor shaft, and the housing shell can comprise cooling ribs, wherein the cooling ribs are arranged and formed such that the air conveyed by the fan impeller sweeps through the cooling ribs. One of the annular sealing areas can include a dead volume chamber. The housing shell may be a casting or a machined extruded profile.

Abstract: The invention relates to fan units for ventilators, in particular for CPAP-apparatus. The fan units comprise a housing, a motor having a stator and a rotor, with the stator being affixed to the housing, and an impeller affixed to the rotor. According to an embodiment the motor is positioned in the suction area of the impeller and the housing forms a suction channel extending helically about the motor axis and being arranged such that the sucked air is accelerated in the direction of rotation of the motor. According to another embodiment the housing in the proximity of the fixtures of the motor is formed such that the housing acts as spring element itself. According to another embodiment a tissue is provided in the fan unit through which the air flows after its compression by the impeller.

Abstract: A shoe has a sole and an upper releasably joined together by a peripheral releasable joining device such as a zipper. The sole has a ridgelike upwardly projecting support member which extends at least partially around the peripheral region of the sole, to form a barrier between the joining device and the interior space of the shoe.

Abstract: A filter cassette having a fanfolded filter medium against which a thin wed strip is cemented on each fanfolded face by means of an edge gluing machine such that on the upstream side it projects slightly over the filter medium. To hold the filter cassette in the filter housing there is a clamping frame, which reaches over the edge of the filter cassette and forces the protruding, upstream side face of the outer strip into a seal of the filter housing and whose two opposing sides have a surface prong that reaches into the outermost fanfold of the filter medium and pushes it into another seal of the filter housing.