Patents by Inventor Peter Helmuth Karuso

Peter Helmuth Karuso has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for synthesizing epicconone analogs
    Patent number: 8669378
    Abstract: The present invention relates to a process for the total synthesis of epicocconone analogs of formula (I): The invention also relates to novel epicocconone analogs.
    Type: Grant
    Filed: October 25, 2010
    Date of Patent: March 11, 2014
    Assignees: Universite de Rouen, Centre National de la Recherche Scientifique-CNRS, Institut National des Sciences Appliquees de Rouen, Macquarie University
    Inventors: Xavier Franck, Philippe Peixoto, Peter Helmuth Karuso
  • PROCESS FOR SYNTHESIZING EPICCONONE ANALOGS
    Publication number: 20120214194
    Abstract: The present invention relates to a process for the total synthesis of epicocconone analogs of formula (I): The invention also relates to novel epicocconone analogs.
    Type: Application
    Filed: October 25, 2010
    Publication date: August 23, 2012
    Applicants: UNIVERSITE DE ROUEN, MACQUARIE UNIVERSITY, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE ROUEN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS
    Inventors: Xavier Franck, Philippe Peixoto, Peter Helmuth Karuso
  • METHOD FOR MONITORING HYDROLYTIC ACTIVITY
    Publication number: 20110159524
    Abstract: The present invention relates to methods of measuring the activity of a hydrolytic agent comprising contacting a biomolecule with a hydrolytic agent in the presence of a fluorescent dye under conditions that allow digestion of the biomolecule by the hydrolytic agent. The fluorescence of the dye is monitored over time and a change in fluorescence signifies digestion of the biomolecule by the hydrolytic agent. The biomolecule is preferably a protein, peptide or proteome but can also be a carbohydrate, oligonucleotide or lipid. Further methods relate to determining an end point for digestion of a biomolecule by a hydrolytic agent, and methods of monitoring digestion of a biomolecule by a hydrolytic agent. The monitoring can be performed on the reaction mixture in real time or via sampling. The invention also relates to kits for carrying out the method.
    Type: Application
    Filed: November 23, 2010
    Publication date: June 30, 2011
    Applicant: FLUOROTECHNICS PTY LIMITED
    Inventors: Peter Helmuth Karuso, Hung-Yoon Choi
  • SYNTHESIS OF AGELADINE A AND ANALOGS THEREOF
    Publication number: 20110152313
    Abstract: The invention describes a one pot process for synthesizing a compound of structure (I), or a tautomer thereof. A compound of structure (II), or a tautomer thereof, and an aldehyde of structure RdCHO are condensed to form a condensation product. The resulting condensation product is then oxidized in the same reaction mixture to produce the compound of structure (I) or a tautomer thereof.
    Type: Application
    Filed: June 19, 2009
    Publication date: June 23, 2011
    Applicant: MACQUARIE UNIVERSITY
    Inventors: Peter Helmuth Karuso, Sudhir Ramnathrao Shengule
  • Method of enhancing fluorescence
    Patent number: 7713694
    Abstract: A method of enhancing the fluorescence of and/or producing an increased Stokes' shift in a fluorescent dye comprising combining the dye with a base and/or a detergent is described. The method is suitable in chemical or biochemical techniques using fluorescent dyes, particularly techniques requiring staining or labeling of organic molecules, such as electrophoresis.
    Type: Grant
    Filed: September 26, 2005
    Date of Patent: May 11, 2010
    Assignee: Fluorotechnics Pty Limited
    Inventors: James Alexander Mackintosh, Duncan Adam Veal, Peter Helmuth Karuso, Daniel Richard Coghlan, Hung-Yoon Choi
  • Method for Monitoring Hydrolytic Activity
    Publication number: 20090111104
    Abstract: The present invention relates to methods of measuring the activity of a hydrolytic agent comprising contacting a biomolecule with a hydrolytic agent in the presence of a fluorescent dye under conditions that allow digestion of the biomolecule by the hydrolytic agent. The fluorescence of the dye is monitored over time and a change in fluorescence signifies digestion of the biomolecule by the hydrolytic agent. The biomolecule is preferably a protein, peptide or proteome but can also be a carbohydrate, oligonucleotide or lipid. Further methods relate to determining an end point for digestion of a biomolecule by a hydrolytic agent, and methods of monitoring digestion of a biomolecule by a hydrolytic agent. The monitoring can be performed on the reaction mixture in real time or via sampling. The invention also relates to kits for carrying out the method.
    Type: Application
    Filed: November 3, 2006
    Publication date: April 30, 2009
    Applicant: Fluorotechnics Pty Limited
    Inventors: Peter Helmuth Karuso, Hung-Yoon Choi