Abstract: The present invention relates to a recombinant Factor VIII protein comprising, in a single chain, a heavy chain portion comprising an A1 and an A2 domain and a light chain portion comprising an A3, C1 and C2 domain of Factor VIII, wherein the B-domain is partially deleted in two deletions, the first leading to the presence of a defined processing sequence cleavable by thrombin, and the second leading to absence of the furin cleavage recognition site at position R1664-R1667. An internal fragment of the B-domain is maintained Nucleic acids encoding said protein, host cells and methods of preparing the protein are also provided, as well as a pharmaceutical composition comprising the protein, nucleic acid or host cell, which may be used for treatment of hemophilia A.

Abstract: Postprocessing of medical images (e.g., MRI and CT images) can be facilitated by a variety of techniques, including training methods which include modular organization and/or online presentation, postprocessing protocols which can be used to specify activities which can be predictably and consistently performed by technologists, and deployment of thin client image processing technology. Additional beneficial results relative to what is possible with the prior art can be obtained by combining one or more of the above approaches.