Patents by Inventor Peter Herbrechtsmeier

Peter Herbrechtsmeier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10429380
    Abstract: The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to a device comprising a hydrogel having a glucose-binding protein and a ligand of the glucose-binding protein incorporated therein, wherein the hydrogel comprises a first hydrogel matrix made of alginate and a second hydrogel matrix which forms an interpenetrating network within the first hydrogel matrix. The invention further relates to the use of such a device for determining the glucose content in a sample and to the use of the device for diagnosing impaired glucose metabolism in a test subject.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: October 1, 2019
    Assignee: EyeSense AG
    Inventors: Achim Müller, Peter Herbrechtsmeier, Monika Knuth, Katharina Nikolaus
  • Patent number: 9826926
    Abstract: The invention relates to a sensor element for detecting at least one analyte in a body fluid or in a body tissue, particularly for determining at least one metabolite concentration in a body fluid. The sensor element comprises an implantable, one-piece shaped body, which comprises a sensor end and a coupling end. The shaped body comprises, in the area of the sensor end, at least one sensor area, which comprises at least one sensor material. The sensor material changes at least one optically measurable property in the presence of the analyte. The shaped body also has at least one optically transparent coupling part, which is designed to transmit electromagnetic radiation in at least one spectral range between the sensor area and the coupling end. In the sensor area, the shaped body has at least one optically transparent matrix material, and the analyte can at least partially diffuse through the matrix material to the sensor material. The sensor material is embedded in the matrix material.
    Type: Grant
    Filed: October 2, 2009
    Date of Patent: November 28, 2017
    Assignee: EyeSense AG
    Inventors: Achim Müller, Peter Herbrechtsmeier
  • Patent number: 9244064
    Abstract: The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to the use of a polymer-based hydrogel consisting of at least one water-soluble polymer in a sensor for enriching a dissolved glucose-binding protein, wherein the at least one water-soluble polymer is capable of interacting with the glucose-binding protein and wherein the glucose-binding protein is present in a complex with a ligand.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: January 26, 2016
    Assignee: EYESENSE AG
    Inventors: Achim Müller, Peter Herbrechtsmeier, Monika Knuth, Katharina Nikolaus
  • Patent number: 8945942
    Abstract: The present invention relates to the use of preparations for stabilizing isolated proteins. In particular, the use of such a preparation for stabilizing receptors in biochemical sensors is disclosed. The invention in addition relates to biochemical sensors containing such preparations.
    Type: Grant
    Filed: October 25, 2010
    Date of Patent: February 3, 2015
    Assignee: Eyesense AG
    Inventors: Peter Herbrechtsmeier, Achim Müller, Monika Knuth, Katharina Nikolaus
  • Patent number: 8652101
    Abstract: The invention relates to an implantation device for implanting a sensor element for detecting at least one analyte in a bodily fluid or body tissue. The implantation device comprises at least one cannula for piercing a skin surface of a patient. The cannula has at least one holding area for holding the sensor element. The implantation device furthermore has at least one hydraulic container, connected to the cannula, for holding a hydraulic fluid and at least one pressure generation device. The pressure generation device is designed to apply pressure to the hydraulic fluid, wherein the sensor element can be transferred from the cannula into the body tissue using the hydraulic fluid.
    Type: Grant
    Filed: October 2, 2009
    Date of Patent: February 18, 2014
    Assignee: EyeSense AG
    Inventors: Achim Müller, Peter Herbrechtsmeier
  • Patent number: 8647271
    Abstract: An implant (110) for detecting at least one analyte (126) in a body fluid, in particular an eye fluid, is proposed. The implant (110) is designed to be implanted in a tissue layer and/or a chamber of an eye of a patient, the implant (110) having a hydrogel matrix (110) with at least one hydrogel (114). The implant (110) also has sensor particles (116) dispersed in the hydrogel matrix (110), the sensor particles (116) having at least one sensor matrix (120) with a sensor matrix material (122) and at least one sensor material (124).
    Type: Grant
    Filed: May 23, 2008
    Date of Patent: February 11, 2014
    Assignee: Eyesense AG
    Inventors: Achim Müller, Peter Herbrechtsmeier, Monika Knuth, Katharina Nikolaus
  • Publication number: 20140024060
    Abstract: The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to the use of a polymer-based hydrogel consisting of at least one water-soluble polymer in a sensor for enriching a dissolved glucose-binding protein, wherein the at least one water-soluble polymer is capable of interacting with the glucose-binding protein and wherein the glucose-binding protein is present in a complex with a ligand.
    Type: Application
    Filed: December 13, 2011
    Publication date: January 23, 2014
    Inventors: Achim Müller, Peter Herbrechtsmeier, Monika Knuth, Katharina Nikolaus
  • Patent number: 8452363
    Abstract: The invention proposes a manual measuring appliance (112) and an analytical measuring system (110) which can be used to measure at least one analyte in an eye fluid of an eye (114). The handheld measuring appliance (112) comprises a measuring system (120) and a positioning system (122). The measuring system (120) can measure at least one property of the at least one analyte and/or at least one analyte-dependent change of property of at least one ocular sensor (116) in the eye fluid, and this can be used to infer a concentration of the analyte in the eye fluid. The positioning system (122) is set up to measure a spatial positioning, wherein the spatial positioning comprises a distance between at least one measurement location in the eye (114) and the handheld measuring appliance (112) and also furthermore at least one further positioning co-ordinate.
    Type: Grant
    Filed: July 23, 2007
    Date of Patent: May 28, 2013
    Assignee: Eyesense AG
    Inventors: Achim Müller, Peter Herbrechtsmeier, Klaus Haberstroh, Roman Gruler
  • Publication number: 20120258551
    Abstract: The present invention relates to the use of preparations for stabilizing isolated proteins. In particular, the use of such a preparation for stabilizing receptors in biochemical sensors is disclosed. The invention in addition relates to biochemical sensors containing such preparations.
    Type: Application
    Filed: October 25, 2010
    Publication date: October 11, 2012
    Inventors: Peter Herbrechtsmeier, Achim Müller, Monika Knuth, Katharina Nikolaus
  • Patent number: 8088313
    Abstract: A measured amount of a material that is crosslinkable by impingement of a suitable form of energy, especially UV light, is introduced into a two-part mould of which the cavity determines the shape of a moulding to be produced. The two mould halves are held a small distance from one another so that a thin annular gap is formed between them, which gap is in communication with the mould cavity and through which gap excess material can escape. The crosslinking is triggered by impingement of the selected form of energy, the impingement being spatially restricted to the cavity by suitable masking so that material disposed outside the mould cavity is not crosslinked. In that manner mouldings are obtained that do not require subsequent mechanical processing, and the mould is reusable. The process is especially, but not, however, exclusively, suitable for the manufacture of contact lenses.
    Type: Grant
    Filed: June 9, 2004
    Date of Patent: January 3, 2012
    Assignee: Novartis AG
    Inventors: Peter Hagmann, Sharla Borghorst, John Golby, Peter Herbrechtsmeier, Otto Kretzschmar, Bernhard Seiferling, Norbert Söllner, Beat Müller
  • Patent number: 8057041
    Abstract: The invention proposes a manual measuring appliance (112) and an analytical measuring system (110) which can be used to measure at least one analyte in an eye fluid of an eye (114). The handheld measuring appliance (112) comprises a measuring system (120) and a positioning system (122). The measuring system (120) can measure at least one property of the at least one analyte and/or at least one analyte-dependent change of property of at least one ocular sensor (116) in the eye fluid, and this can be used to infer a concentration of the analyte in the eye fluid. The positioning system (122) is set up to measure a spatial positioning, wherein the spatial positioning comprises a distance between at least one measurement location in the eye (114) and the handheld measuring appliance (112) and also furthermore at least one further positioning co-ordinate.
    Type: Grant
    Filed: July 23, 2007
    Date of Patent: November 15, 2011
    Assignee: EyeSense AG
    Inventors: Achim Müller, Peter Herbrechtsmeier, Klaus Haberstroh, Roman Gruler
  • Publication number: 20110230835
    Abstract: The invention relates to an implantation device for implanting a sensor element for detecting at least one analyte in a bodily fluid or body tissue. The implantation device comprises at least one cannula for piercing a skin surface of a patient. The cannula has at least one holding area for holding the sensor element. The implantation device furthermore has at least one hydraulic container, connected to the cannula, for holding a hydraulic fluid and at least one pressure generation device. The pressure generation device is designed to apply pressure to the hydraulic fluid, wherein the sensor element can be transferred from the cannula into the body tissue using the hydraulic fluid.
    Type: Application
    Filed: October 2, 2009
    Publication date: September 22, 2011
    Applicant: EyeSense AG
    Inventors: Achim Müller, Peter Herbrechtsmeier
  • Publication number: 20110224514
    Abstract: The invention relates to a sensor element (110) for detecting at least one analyte in a body fluid or in a body tissue (130), particularly for determining at least one metabolite concentration in a body fluid. The sensor element (110) comprises an implantable, one-piece shaped body (112), which comprises a sensor end (114) and a coupling end (116). The shaped body (112) comprises, in the area of the sensor end (114), at least one sensor area (118), which comprises at least one sensor material (122). The sensor material (122) changes at least one optically measurable property in the presence of the analyte. The shaped body (112) also has at least one optically transparent coupling part (120), which is designed to transmit electromagnetic radiation in at least one spectral range between the sensor area (118) and the coupling end (116).
    Type: Application
    Filed: October 2, 2009
    Publication date: September 15, 2011
    Applicant: EyeSense AG
    Inventors: Achim Müller, Peter Herbrechtsmeier
  • Publication number: 20100331634
    Abstract: An implant (110) for detecting at least one analyte (126) in a body fluid, in particular an eye fluid, is proposed. The implant (110) is designed to be implanted in a tissue layer and/or a chamber of an eye of a patient, the implant (110) having a hydrogel matrix (110) with at least one hydrogel (114). The implant (110) also has sensor particles (116) dispersed in the hydrogel matrix (110), the sensor particles (116) having at least one sensor matrix (120) with a sensor matrix material (122) and at least one sensor material (124).
    Type: Application
    Filed: May 23, 2008
    Publication date: December 30, 2010
    Applicant: Eyesense AG
    Inventors: Achim Müller, Peter Herbrechtsmeier, Monika Knuth, Katharina Nikolaus
  • Publication number: 20100063371
    Abstract: The invention proposes a manual measuring appliance (112) and an analytical measuring system (110) which can be used to measure at least one analyte in an eye fluid of an eye (114). The handheld measuring appliance (112) comprises a measuring system (120) and a positioning system (122). The measuring system (120) can measure at least one property of the at least one analyte and/or at least one analyte-dependent change of property of at least one ocular sensor (116) in the eye fluid, and this can be used to infer a concentration of the analyte in the eye fluid. The positioning system (122) is set up to measure a spatial positioning, wherein the spatial positioning comprises a distance between at least one measurement location in the eye (114) and the handheld measuring appliance (112) and also furthermore at least one further positioning co-ordinate.
    Type: Application
    Filed: July 23, 2007
    Publication date: March 11, 2010
    Applicant: EYESENSE AG
    Inventors: Achim Müller, Peter Herbrechtsmeier, Klaus Haberstroh
  • Publication number: 20080249381
    Abstract: A combined apparatus for measuring the blood glucose level from an ocular fluid comprises a hand-held fluorescence photometer (D1) for determining the glucose level of the ocular fluid and a device (D2) for the amperometric or photometric determination of the blood glucose level. The fluorescence photometer (D1) comprises: first irradiating means (7,8,10) for providing a pilot beam (1) for irradiation of the eye (3) in order to excite a first fluorescence comprising a first wavelength band; first detecting means (8,9,12,13) for measuring the intensity of the of the pupil fluorescence within the first wavelength band; second irradiating means (17,18,21) for providing a measurement beam (5) for irradiation of the eye in order to excite an ocular sensor (4) to emit a second fluorescence comprising a second wavelength band; second detecting means (18,19,20,22,23,24,25) for measuring the intensity of the second fluorescence within the second wavelength band.
    Type: Application
    Filed: June 13, 2005
    Publication date: October 9, 2008
    Inventors: Achim Muller, Peter Herbrechtsmeier, Bernhard Seiferling, Wolfgang Hofmann
  • Publication number: 20070213638
    Abstract: The invention relates to a device for drawing a sample and analyzing body fluids, and to a corresponding method. The device comprises a handle (1), which accommodates a pneumatic drive device, and a sensor unit (2) that contains a microneedle (3) on an elastic membrane (4) and at least one sensor system (5). The handle (1) and the sensor unit are detachably connected to one another, and the pneumatic drive device interacts with the sensor unit (2) in such a manner that the drive device exerts pressure onto the elastic membrane (4) so that the microneedle (3) pierces the surface of the skin in order to draw body fluid. During the ensuing decreasing pressure, the elastic membrane (4) returns to its original shape, and body fluid is suctioned, due to the resulting underpressure, from the location of piercing and into the interior of the sensor unit (2) to the at least one sensor system (5).
    Type: Application
    Filed: June 25, 2004
    Publication date: September 13, 2007
    Inventors: Peter Herbrechtsmeier, Wolfgang Ehrfeld, Karoly Nagy, Stefan Kammermeier, Alexander Azzawi, Egbert Linnebach, Thomas Schwank
  • Publication number: 20040222539
    Abstract: A measured amount of a material that is crosslinkable by impingement of a suitable form of energy, especially UV light, is introduced into a two-part mould of which the cavity determines the shape of a moulding to be produced. The two mould halves are held a small distance from one another so that a thin annular gap is formed between them, which gap is in communication with the mould cavity and through which gap excess material can escape. The crosslinking is triggered by impingement of the selected form of energy, the impingement being spatially restricted to the cavity by suitable masking so that material disposed outside the mould cavity is not crosslinked. In that manner mouldings are obtained that do not require subsequent mechanical processing, and the mould is reusable. The process is especially, but not, however, exclusively, suitable for the manufacture of contact lenses.
    Type: Application
    Filed: June 9, 2004
    Publication date: November 11, 2004
    Inventors: Peter Hagmann, Sharla Borghorst, John Golby, Peter Herbrechtsmeier, Otto Kretzchmar, Bernhard Seiferling, Norbert Sollner, Beat Muller
  • Patent number: 6800225
    Abstract: A measured amount of a material that is crosslinkable by impingement of a suitable form of energy, especially UV light, is introduced into a two-part mould of which cavity determines the shape of a moulding to be produced. The two mould halves are held a small distance from one another so that a thin annular gap is formed between them, which gap is in communication with the mould cavity and through which gap excess material can escape. The crosslinking is triggered by impingement of the selected form of energy, the impingement being spatially restricted to the cavity by suitable masking so that material disposed outside the mould cavity is not crosslinked. In that manner mouldings are obtained that do not require subsequent mechanical processing, and the mould is reusable. The process is especially, but not, however, exclusively, suitable for the manufacture of contact lenses.
    Type: Grant
    Filed: July 14, 1994
    Date of Patent: October 5, 2004
    Assignee: Novartis AG
    Inventors: Peter Hagmann, Sharla Borghorst, John Golby, Peter Herbrechtsmeier, Otto Kretzschmar, Bernhard Seiferling, Norbert Söllner, Beat Müller
  • Patent number: 6627124
    Abstract: The invention tackles the problem of improving the production process for contact lenses further, so that the production costs for contact lenses can be reduced further and the production capacities can be increased. To this end, provision is made for the two mould halves, which together form the mould for producing a contact lens, to be fixed to each other and/or detachably connected to each other by means of individual half-mould guide. In conjunction with a cyclic production process, a high degree of automation can be achieved in this way.
    Type: Grant
    Filed: December 14, 2000
    Date of Patent: September 30, 2003
    Assignee: Novartis AG
    Inventors: Peter Herbrechtsmeier, Peter Hagmann, Roger Biel, Axel Heinrich, Wilhelm Hörner, Egbert Jux, Anette Therese Lang-Schöll, Iris Jlona Leder-Brück, Achim Müller, Bernhard Seiferling, Werner Steffan