Abstract: A heat barrier laminate for use as a skin, the laminate comprising in the following order: a) a radiant barrier layer, b) a heat-insulating layer comprising a first polymer, c) a spacer layer comprising a fabric, and d) a heat-insulating layer comprising a second polymer, wherein the first polymer and/or the second polymer comprise a heat-insulating filler selected from hollow glass particles, hollow ceramic particles, hollow polymer particles, and a combination thereof.

Abstract: A shearing blade for a cutting device includes a main body that has a seat and a blade insert that is arranged on the seat and forms a cutting wedge, wherein the cutting wedge forms a cutting edge via a flank face and a pressure face at an angle to the flank face. The seat has at least one undercut face that acts in a direction transverse to the flank face. When the blade insert is inserted, the undercut face interacts with at least one form-closure face formed on the blade insert, whereby a form closure taking effect transversely to the flank face is established. The blade insert is fastened to the main body by at least one pin-shaped plug-in connection element, which is oriented perpendicular to the flank face and which is arranged in aligned holes in the main body and in the blade insert.

Abstract: The invention relates to a spreader tip (32) for replaceable attachment to two pincer-like co-operating spreader arms (4) of a rescue tool (1). Mounted on a working face (35) of the spreader tip (32) is at least one insert element (39) which protrudes from and has different material properties in comparison with the spreader tip (32).

Abstract: The invention relates to a spreader tip (32) for replaceable attachment to two pincer-like co-operating spreader arms (4) of a rescue tool (1). Mounted on a working face (35) of the spreader tip (32) is at least one insert element (39) which protrudes from and has different material properties in comparison with the spreader tip (32).

Abstract: The invention relates to a cutting device providing a main frame body, at least one stationary cutting element disposed on the main frame body, a drive system disposed on the main frame body, in particular in the form of a fluid cylinder, and a cutting blade drivingly connected to the drive system and guided in its movement on the main frame body, which co-operates with the stationary cutting element. The main frame body and/or the drive system is made from an essentially light metal or a light metal alloy with a density of less than 5000 kg/m3, in particular less than 3000 kg/m3.

Abstract: The present invention relates to methods, agents and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts. The invention thus provides a method, comprising contacting a compound with a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID No: 194-309; and measuring a compound-polypeptide property related to the differentiation of said cells. The invention further relates to a bone formation enhancing pharmaceutical composition, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean bone density in a subject. Furthermore, the invention relates to a method for the in vitro production of bone tissue.

Abstract: The invention relates to a photovoltaic system with a plastic support and a photovoltaic module for installation on roofs. The plastic support (1) may be mounted directly to a roof substructure, so that an additional roof covering can be dispensed with. The photovoltaic modules may be fixed on the plastic support (1) without screwing.

Abstract: The invention relates to a shearing blade (2) for a cutting device (1), comprising a main body (3) that has a seat (11) and a blade insert (4) that is arranged on the seat (11) and forms a cutting wedge (8), wherein the cutting wedge (8) forms a cutting edge (6) by means of a flank face (9) and a pressure face (10) at an angle to the flank face. The seat (11) has at least one undercut face (13, 28) that acts in a direction transverse to the flank face (9). When the blade insert (4) is inserted, the undercut face (13, 28) interacts with at least one form-closure face (16, 27) formed on the blade insert, whereby a form closure taking effect transversely to the flank face (9) is established. The blade insert (4) is fastened to the main body (3) by means of at least one pin-shaped plug-in connection element (5), which is oriented perpendicular to the flank face (9) and which is arranged in aligned holes (18, 19) in the main body (3) and in the blade insert (4).

Abstract: The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inducing anabolic stimulation of chondrocytes, including cartilage formation enhancing pharmaceutical compositions, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean cartilage thickness in a subject.

Abstract: The application discloses methods for identifying and using compounds that inhibit extra-cellular matrix (ECM) degradation and inflammation, using a polypeptide sequence including SEQ ID NO: 17-127 (hereinafter “TARGETS”) and fragments thereof, expression inhibitory agents such as antisense polynucleotide, a ribozyme, and a small interfering RNA (siRNA), comprising a nucleic acid sequence complementary to, or engineered from, a naturally occurring polynucleotide sequence encoding a polypeptide of SEQ ID NO: 17-127, useful in pharmaceutical compositions comprising said agent, for the treatment, or prevention, of chronic joint degenerative and/or inflammatory diseases such as rheumatoid arthritis.

Abstract: The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inducing anabolic stimulation of chondrocytes, including cartilage formation enhancing pharmaceutical compositions, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean cartilage thickness in a subject.

Abstract: The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts, including bone formation enhancing pharmaceutical compositions, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean bone density in a subject.

Abstract: The present invention relates to methods, agents and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts. The invention thus provides a method, comprising contacting a compound with a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID No: 194-309; and measuring a compound-polypeptide property related to the differentiation of said cells. The invention further relates to a bone formation enhancing pharmaceutical composition, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean bone density in a subject. Furthermore, the invention relates to a method for the in vitro production of bone tissue.

Abstract: The application discloses methods for identifying and using compounds that inhibit extra-cellular matrix (ECM) degradation and inflammation, using a polypeptide sequence including SEQ ID NO: 17-127 (hereinafter “TARGETS”) and fragments thereof, expression inhibitory agents such as antisense polynucleotide, a ribozyme, and a small interfering RNA (siRNA), comprising a nucleic acid sequence complementary to, or engineered from, a naturally occurring polynucleotide sequence encoding a polypeptide of SEQ ID NO: 17-127, useful in pharmaceutical compositions comprising said agent, for the treatment, or prevention, of chronic joint degenerative and/or inflammatory diseases such as rheumatoid arthritis.

Abstract: The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inducing anabolic stimulation of chondrocytes, including cartilage formation enhancing pharmaceutical compositions, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean cartilage thickness in a subject.

Abstract: The invention relates to a cutting device (1) comprising a main frame body (2), at least one stationary cutting element (20) disposed on the main frame body (2), a drive system (4) disposed on the main frame body (2), in particular in the form of a fluid cylinder (7), and a cutting blade (5) drivingly connected to the drive system (4) and guided in its movement on the main frame body (2) which co-operates with the stationary cutting element (20). The main frame body (2) and/or the drive system (4) is made from an essentially light metal or a light metal alloy with a density of less than 5000 kg/m3, in particular less than 3000 kg/m3.

Abstract: The application discloses methods for identifying and using compounds that inhibit extra-cellular matrix (ECM) degradation and inflammation, using a polypeptide sequence including SEQ ID NO: 17-127 (hereinafter “TARGETS”) and fragments thereof, expression inhibitory agents such as antisense polynucleotide, a ribozyme, and a small interfering RNA (siRNA), comprising a nucleic acid sequence complementary to, or engineered from, a naturally occurring polynucleotide sequence encoding a polypeptide of SEQ ID NO: 17-127, useful in pharmaceutical compositions comprising said agent, for the treatment, or prevention, of chronic joint degenerative and/or inflammatory diseases such as rheumatoid arthritis.

Abstract: A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a GPCR polypeptide, or fragment thereof, and measuring a compound-GPCR property related to the production of amyloid-beta peptide. Cellular assays of the method measure indicators including second messenger and/or amyloid beta peptide levels. Therapeutic methods, and pharmaceutical compositions including effective amyloid-beta precursor processing-inhibiting amounts of GPCR expression inhibitors, are useful for treating conditions involving cognitive impairment such as Alzheimers Disease.

Abstract: The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inhibiting extra-cellular matrix degradation, including joint degenerative inhibiting and/or anti-inflammatory pharmaceutical compositions, and the use thereof in treating and/or preventing a disease involving extra-cellular matrix degradation in a subject.

Abstract: The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inhibiting extra-cellular matrix degradation, including joint degenerative inhibiting and/or anti-inflammatory pharmaceutical compositions, and the use thereof in treating and/or preventing a disease involving extra-cellular matrix degradation in a subject.