Abstract: Embodiments disclosed herein include a three-dimensional display, such as a flower bouquet, that is arranged to be popped open. The three-dimensional display includes an outer layer and one or more elastomeric or biasing members arranged pop open and/or to hold the display in the open position. In some embodiments, the outer layer includes flower with stems and leaves. In some embodiments, the bouquet includes inner layers attachable to the outer layer. In some embodiments, the elastomeric or biasing member includes one or more elastic bands. In some embodiments, the three-dimensional display may be popped open by pressing the side panels of the display.

Abstract: The present invention relates to a compound that is useful as an inhibitor of the activity of Wee-1 kinase. The present invention also relates to pharmaceutical compositions comprising this compound and to methods of using this compound in the treatment of cancer and methods of treating cancer.

Abstract: Embodiments disclosed herein include a three-dimensional display, such as a flower bouquet, that is arranged to be popped open. The three-dimensional display includes an outer layer and one or more elastomeric or biasing members arranged pop open and/or to hold the display in the open position. In some embodiments, the outer layer includes flower with stems and leaves. In some embodiments, the bouquet includes inner layers attachable to the outer layer. In some embodiments, the elastomeric or biasing member includes one or more elastic bands. In some embodiments, the three-dimensional display may be popped open by pressing the side panels of the display.

Abstract: Provided are USP19 inhibitors, methods of treating obesity, metabolic syndrome and/or diabetes using the USP19 inhibitor compounds, as well as those compounds for use in methods of treating obesity, metabolic syndrome and/or diabetes. Also provided are methods of treating muscular atrophy, for example cachexia or sarcopenia with USP19 inhibitor compounds, plus those compounds for use in methods of treating muscular atrophy.

Abstract: The present invention relates to compounds of Formula (I) that are useful as inhibitors of the activity of the ubiquitin specific protease USP19. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in therapy.

Abstract: The present invention relates to a compound that is useful as an inhibitor of the activity of Wee-1 kinase. The present invention also relates to pharmaceutical compositions comprising this compound and to methods of using this compound in the treatment of cancer and methods of treating cancer.

Abstract: The present invention relates to compounds of Formula (I) that are useful as inhibitors of the activity of the ubiquitin specific protease USP19. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in therapy.

Abstract: The present invention relates to a compound that is useful as an inhibitor of the activity of Wee-1 kinase. The present invention also relates to pharmaceutical compositions comprising this compound and to methods of using this compound in the treatment of cancer and methods of treating cancer.

Abstract: The present invention concerns the identification of inhibitors of ubiquitin specific protease 7 (USP7), and methods of use thereof.

Abstract: The present invention concerns the identification of inhibitors of ubiquitin specific protease 7 (USP7), and methods of use thereof.

Abstract: The present invention relates to compounds of Formula (I) that are useful as inhibitors of the activity of the ubiquitin specific protease USP19. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in therapy.

Abstract: A cover for a container in which the cover is formed with a first opening to which a mesh pouch is secured to hold fragments of tea leaves or other infusible consumable products. The opening is positioned on one side of a diameter of the cover with a remote sip hole in the cover. A second opening in the cover provides for inclusion of other ingredients and stirring the beverage.

Abstract: The invention relates to azaindolizines of formula I-a or I-b with anti-cancer and/or anti-inflammatory activity and more specifically to azaindolizines which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

Abstract: The invention relates to azaindolizines of formula I-a or I-b with anti-cancer and/or anti-inflammatory activity and more specifically to azaindolizines which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

Abstract: A versatile system which includes a display unit by which a plurality of image works selected from photographs, paintings, newspaper articles, pictures, images, prints, designs, sports memorabilia, certificates, awards, and diplomas may be viewed simultaneously or individually, as selected by the viewer. A display unit stores a plurality of image works for selective viewing by an observer by virtue of each image works being mounted on a slidable carrier, which may be slid within a framework to enable or disable viewing of image works which may be disposed behind a given slidable carrier.

Abstract: The instant invention relates to a method and an apparatus useful for purifying DNA sequencing reaction products. Briefly, a gel filtration medium is combined with a molecular cutoff filter in a single apparatus to isolate DNA sequencing fragments from the sequencing template, enzyme, salt and nucleotides. A preferred embodiment of the instant apparatus depicted in FIG. 1 shows a cylindrical housing having openings at the top and bottom of the housing. The housing may take forms other than cylindrical, e.g., rectangular, octagonal, etc.