Patents by Inventor Peter Hilgard
Peter Hilgard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6903080Abstract: A method of treating protozoal and fungal diseases is described, in which an effective amount of a compound of formula I is administered to a host having a protozoal or fungal disease.Type: GrantFiled: November 8, 2002Date of Patent: June 7, 2005Assignee: Zentaris GmbHInventors: Gerhard Nossner, Bernhard Kutscher, Jurgen Engel, Wolfgang Schumacher, Margrit Stekar, Peter Hilgard, Jurij Stekar
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Patent number: 6696428Abstract: The side effect of decrease in body weight caused by the alkylphosphocholines such as miltefosine can be antagonized by certain acetylcholine receptor antagonists such as domperidone and pimozide. The combination of alkylphosphocholine plus the antagonist does not have any effect on the anti-tumor action of the alkylphosphocholine. The combination also caused no new side effects in the animals.Type: GrantFiled: August 2, 2002Date of Patent: February 24, 2004Assignee: Zentaris AGInventors: Bernd Nickel, Peter Hilgard, Thomas Klenner, Jürgen Engel
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Publication number: 20030153533Abstract: Novel phospholipid derivatives of the General Formula I: 1Type: ApplicationFiled: November 8, 2002Publication date: August 14, 2003Applicant: Zentaris AGInventors: Gerhard Nossner, Bernhard Kutscher, Jurgen Engel, Wolfgang Schumacher, Jurij Stekar, Peter Hilgard
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Patent number: 6576624Abstract: The side effect of decrease in body weight caused by the alkylphosphocholines such as miltefosine can be antagonized by certain acetylcholine receptor antagonists such as domperidone and pimozide. The combination of alkylphosphocholine plus the antagonist does not have any effect on the anti-tumor action of the alkylphosphocholine. The combination also caused no new side effects in the animals.Type: GrantFiled: June 23, 2000Date of Patent: June 10, 2003Assignee: Zentaris AGInventors: Bernd Nickel, Peter Hilgard, Thomas Klenner, Jürgen Engel
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Patent number: 6544551Abstract: The present invention relates to new solid pharmaceutical compositions containing hexadecylphosphocholine (miltefosine) for oral administration in the treatment of leishmaniasis, a process for the manufacture of said pharmaceutical composition, a dosage scheme for oral administration of said pharmaceutical composition in the treatment of leishmaniasis, and finally a combination comprising said solid pharmaceutical composition, antiemeticum, and/or an antidiarrhoeal.Type: GrantFiled: July 24, 2000Date of Patent: April 8, 2003Assignee: Zentaris AGInventors: Juergen Engel, Werner Sarlikiotis, Thomas Klenner, Peter Hilgard, Dieter Sauerbier, Eckhard Milsmann
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Publication number: 20030040507Abstract: The invention relates to the use of a combination of ifosfamide and carnitine, in particular L-carnitine, for the production of tumour pharmaceuticals having decreased side effects. The results show clearly that the side effect produced by ifosfamide (damage to the proximal tubule of the kidney) is antagonized in animals by L-carnitine. It was furthermore possible to show that the antitumour action of ifosfamide is not affected in combination with L-carnitine. The combination also caused no new side effects in the animals.Type: ApplicationFiled: October 9, 2002Publication date: February 27, 2003Inventors: Bernd Nickel, Joerg Pohl, Thomas Nolte, Peter Hilgard, Jurgen Engel, J. S. Schlenzig
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Publication number: 20030008846Abstract: The side effect of decrease in body weight caused by the alkylphosphocholines such as miltefosine can be antagonized by certain acetylcholine receptor antagonists such as domperidone and pimozide. The combination of alkylphosphocholine plus the antagonist does not have any effect on the anti-tumor action of the alkylphosphocholine. The combination also caused no new side effects in the animals.Type: ApplicationFiled: August 2, 2002Publication date: January 9, 2003Applicant: Degussa AGInventors: Bernd Nickel, Peter Hilgard, Thomas Klenner, Jurgen Engel
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Patent number: 6479472Abstract: A method of treating protozoal and fungal diseases is described, in which an effective amount of a compound of formula I is administered to a host having a protozoal or fungal disease.Type: GrantFiled: September 29, 2000Date of Patent: November 12, 2002Assignee: Asta Medica AktiengesellschaftInventors: Gerhard Nössner, Bernhard Kutscher, Jürgen Engel, Wolfgang Schumacher, Jurij Stekar, Peter Hilgard
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Patent number: 6172050Abstract: Phospholipid derivatives of Formula X: wherein A is the ring system in which R is a linear or branched alkyl radical having 10 to 24 carbon atoms which may contain one or more double or triple bonds; R1 and R2 are independently hydrogen or linear alkyl radicals having 1 to 3 carbon atoms; y is 0, 1, 2 or 3; m and n are independently 0 or in an integer, with the proviso that m+n is between 2 and 8; or A is a tropanio or quinuclidinio ring system, which is linked via a carbon-carbon bond and is optionally substituted by one or more methyl groups; processes for the preparation of the derivatives, and methods for treating tumors therewith.Type: GrantFiled: August 4, 1997Date of Patent: January 9, 2001Assignee: Asta Medica AktiengesellschaftInventors: Gerhard Nössner, Bernhard Kutscher, J{umlaut over (u)}rgen Engel, Wolfgang Schumacher, Jurij Stekar, Peter Hilgard
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Patent number: 6093704Abstract: The side effect of decrease in body weight caused by the alkylphosphocholines such as miltefosine can be antagonized by certain acetylcholine receptor antagonists such as domperidone and pimozide. The combination of alkylphosphocholine plus the antagonist does not have any effect on the anti-tumor action of the alkylphosphocholine. The combination also caused no new side effects in the animals.Type: GrantFiled: December 5, 1997Date of Patent: July 25, 2000Assignee: ASTA Medica AktiengesellschaftInventors: Bernd Nickel, Peter Hilgard, Thomas Klenner, Jurgen Engel
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Patent number: 5958906Abstract: Phospholipid derivatives containing higher elements of the Vth main group (P, As, Sb, Bi), their method of preparation and antineoplastic and antimicrobially active medications that can be prepared from the phospholipid derivatives.Type: GrantFiled: May 7, 1997Date of Patent: September 28, 1999Assignee: ASTA-Medica AktiengesellschaftInventors: Gerhard Nossner, Jurij Stekar, deceased, Peter Hilgard, Bernhard Kutscher, Jurgen Engel
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Patent number: 5773032Abstract: Poorly soluble salts of LHRH analogues, for example cetrorelix embonate, display an intrinsic sustained release effect in the grain size 5 .mu.m to 200 .mu.m.Type: GrantFiled: June 10, 1996Date of Patent: June 30, 1998Assignee: Asta Medica AktiengellschaftInventors: Jurgen Engel, Karin Klokkers-Bethke, Thomas Reissman, Peter Hilgard
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Patent number: 5663145Abstract: For application during the treatment of benign and malign tumour diseases, the product according to the invention containing the initial dose of Cetrorelix acetate and one or more maintenance doses of Cetrorelix acetate, Cetrorelix embonate or a slow-release form of Cetrorelix, is used as a combination preparation for treatment to be administered at specific time intervals.Type: GrantFiled: December 8, 1994Date of Patent: September 2, 1997Assignee: ASTA Medica AktiengesellschaftInventors: Jurgen Engel, Peter Hilgard, Thomas Reissmann
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Patent number: 5637577Abstract: Phospholipid derivatives containing higher elements of the Vth main group (P, As, Sb, Bi), their method of preparation and antineoplastic and antimicrobially active medications that can be prepared from the phospholipid derivatives.Type: GrantFiled: April 14, 1995Date of Patent: June 10, 1997Assignee: Asta Medica AktiengesellschaftInventors: Gerhard Nossner, Jurij Stekar, Peter Hilgard, Bernhard Kutscher, Jurgen Engel
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Patent number: 5449798Abstract: Phospholipid derivatives containing higher elements of the Vth main group (P, As, Sb, Bi), their method of preparation and antineoplastic and antimicrobially active medications that can be prepared from the phospholipid derivatives.Type: GrantFiled: September 22, 1993Date of Patent: September 12, 1995Assignee: Asta Medica AktiengesellschaftInventors: Gerhard Nossner, Jurij Stekar, Peter Hilgard, Bernhard Kutscher, Jurgen Engel
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Patent number: 5238955Abstract: Antitumor acting platinum(II or IV) complexes of the general formula ##STR1## where B represents a phenyl-C.sub.1 -C.sub.4 -alkyl radical which is optionally substituted in the phenyl nucleus by the radical R.sub.1 and R.sub.1 is hydrogen, halogen, trihalogen methyl, C.sub.1 -C.sub.6 -alkyl, hydroxy, C.sub.1 -C.sub.6 -alkoxy or C.sub.2 -C.sub.6 -alkanoyloxy or where B together with the structural part H.sub.2 N-CR.sub.2 < forms a tetrahydroisoquinoline radical, if B contains benzyl and R.sub.2 hydrogen and the benzyl radical in the 2-position contains the CH.sub.2 -radical or where B together with the structural part --CR.sub.2 < represents a tetrahydronaphthyl radical in which one CH.sub.2 group is optionally replaced by oxygen, or where B together with the structural part --CR.sub.2 < represents a decahydronaphthyl radical or an indanyl radical; R.sub.2 represents hydrogen, C.sub.1 -C.sub.6 -alkyl, phenyl or phenyl-C.sub.1 -C.sub.4 -alkyl, it also being possible for the phenyl ring of this group R.Type: GrantFiled: November 25, 1992Date of Patent: August 24, 1993Assignee: Asta Pharma AGInventors: Henri Brunner, Peter Hankofer, Friedrich Maiterth, Jurgen Engel, Wolfgang Schumacher, Peter Hilgard, Rainer Voegeli
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Patent number: 5219866Abstract: Octadecyl-[2-(N-methylpiperidino)-ethyl]-phosphate and a process for its preparation. This compound is useful for the treatment of cancer.Type: GrantFiled: July 1, 1992Date of Patent: June 15, 1993Assignee: Asta Medica AGInventors: Wolfgang Schumacher, Jurgen Engel, Gerhard Nossner, Bernhard Kutscher, Jurij Stekar, Peter Hilgard
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Patent number: 5194644Abstract: Antitumor acting platinum(II or IV) complexes of the general formula ##STR1## where B represents a phenyl-C.sub.1 -C.sub.4 -alkyl radical which is optionally substituted in the phenyl nucleus by the radical R.sub.1 and R.sub.1 is hydrogen, halogen, trihalogen methyl, C.sub.1 -C.sub.6 -alkyl, hydroxy, C.sub.1 -C.sub.6 -alkoxy or C.sub.2 -C.sub.6 -alkanoyloxy or where B together with the structural part H.sub.2 N--CR.sub.2 <forms a tetrahydroisoquinoline radical, if B contains benzyl and R.sub.2 hydrogen and the benzyl radical in the 2-position contains the CH.sub.2 -radical or where B together with the structural part --CR.sub.2 < represents a tetrahydronaphthyl radical in which one CH.sub.2 group is optionally replaced by oxygen, or where B together with the structural part --CR.sub.2 < represents a decahydronaphthyl radical or an indanyl radical; R.sub.2 represents hydrogen, C.sub.1 -C.sub.6 -alkyl, phenyl or phenyl-C.sub.1 -C.sub.4 -alkyl, it also being possible for the phenyl ring of this group R.Type: GrantFiled: April 10, 1991Date of Patent: March 16, 1993Assignee: Asta Pharma AGInventors: Henri Brunner, Peter Hankofer, Friedrich Maiterth, Jurgen Engel, Wolfgang Schumacher, Peter Hilgard, Rainer Voegeli
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Patent number: 5023335Abstract: 1,2-Bis(aminomethyl)-cyclobutane-platinum complexes having an anti-tumor activity.Type: GrantFiled: September 25, 1990Date of Patent: June 11, 1991Assignee: ASTA Pharma AktiengesellschaftInventors: Wolfgang Schumacher, Johannes Respondek, Jurgen Engel, Jorg Pohl, Rainer Voegeli, Peter Hilgard
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Patent number: 4716242Abstract: There are provided new antitumor salts of oxazaphosphorine derivatives of the formula ##STR1## where R.sub.1, R.sub.2, and R.sub.3 are the same or different and represent hydrogen, methyl, ethyl, 2-chloroethyl, or 2-methanesulfonyloxyethyl and wherein at least two of these residues are 2-chloroethyl and/or 2-methanesulfonyl-oxyethyl and A is the group --S--alk--SO.sub.3 H or --N(OH)--CONH--alk--CO.sub.2 H and alk represents a C.sub.2 -C.sub.6 -alkylene residue optionally containing a mercapto group, whereby alk also can be --CH.sub.2 -- in case there is a carboxy group attached to the alk group, with homocysteinethiolactone or .alpha.-amino-.epsilon.-caprolactam or a basic compound of the formula: ##STR2## wherein R.sub.4 is a hydroxy group, an amino group or a C.sub.1 -C.sub.6 -alkoxy group, R.sub.5 is hydrogen or a difluoromethyl group, R.sub.6 is hydrogen, an indolyl-(3)-methyl residue, imidazolyl-(4)-methyl residue, a C.sub.1 -C.sub.10 -alkyl group or a C.sub.1 -C.sub.Type: GrantFiled: February 22, 1985Date of Patent: December 29, 1987Assignee: Asta-Werke Aktiengesellschaft Chemische FabrikInventors: Jurgen Engel, Axel Kleemann, Ulf Niemeyer, Peter Hilgard, Joerg Pohl