Abstract: The present invention relates to the identification of biological markers of ovarian cancer. Specifically, cancer-associated autoantibodies to ANXA1, ARP3, SAHH, SERPH, ARAP1, OTUB1, ATP1A1, UBA1, and CFAH have been identified in subjects with early stage ovarian cancer. These autoantibodies can be utilised for a range of purposes including methods for detecting ovarian cancer, methods for screening for early stage ovarian cancer, and methods for assessing treatment response as well as disease progression and recurrence. The autoantibodies also represent prognostic markers of ovarian cancer development.

Abstract: The present invention provides biological markers associated with gastric cancer. In particular, the present invention provides a method of diagnosing gastric cancer (GC) in a subject, the method including: measuring an expression level of one or more proteins in the subject, wherein the one or more proteins are selected from the group consisting of vitamin D binding protein (VDBP), clusterin, insulin like growth factor binding protein complex acid labile subunit (IGFALS), and afamin; comparing the expression level of the or each protein in the subject to a reference expression level for the or each protein; and diagnosing GC in the subject on the basis of the comparison.

Abstract: The present invention relates to an aqueous coating composition comprising at least one aqueous dispersion comprising at least one copolymer (CP), said copolymer (CP) being preparable by (i) initially charging an aqueous dispersion of at least one polyurethane, and then (ii) polymerizing a mixture of olefinically unsaturated monomers in the presence of the polyurethane from (i), in which (a) a water-soluble initiator is used, (b) the olefinically unsaturated monomers are metered in such that a concentration of 6.0% by weight, based on the total amount of olefinically unsaturated monomers used for polymerization, in the reaction solution is not exceeded over the entire reaction time, and (c) the mixture of the olefinically unsaturated monomers comprises at least one polyolefinically unsaturated monomer and at least one linear hydroxy-functional reaction product (R) having an acid number less than 20 mg KOH/g, the preparation of which involves using at least one compound (v) containing two functional groups (v.

Abstract: Described herein is a method for producing a coating system on a substrate, including producing a cured basecoat film on the substrate by applying a pigmented aqueous basecoat material to the substrate and subsequently curing the basecoat material, wherein the basecoat material includes a polyether-based reaction product which is preparable by reaction of (a) at least one cyclic tetracarboxylic dianhydride having an aliphatic, aromatic or araliphatic radical X which bridges the two anhydride groups, with (b) at least one polyether of a general structural formula (II) in which R is a C3 to C6 alkylene radical and n is selected such that the polyether (b) possesses a number-average molecular weight of 500 to 5000 g/mol, and wherein components (a) and (b) are used in the reaction in a molar ratio of 0.7/2.3 to 1.6/1.7 and a resulting reaction product possesses an acid number of 5 to 80 mg KOH/g.

Abstract: The present invention relates to a door (10) for a domestic appliance, in particular an oven door (10) for a cooking oven. The door (10) comprises a front panel (12) and at least one door handle (14) made of metal and arranged at an outer side of said front panel (12). The door (10) comprises at least one electric and/or electronic device (18) arranged inside and/or at the door handle (14). The door (10) comprises at least one fastening element (24) for fastening the door handle (14) at the front panel (12). At least one conducting element (26) is attached at the inner side and/or outer side of the front panel (12).

Abstract: A door holder, includes a retainer housing (230), which can be connected either to a door or a door frame, and a door retainer rod, which penetrates the retainer housing (230) and which can be articulated to the other of the door and the door frame The door retainer rod has at least one braking surface, and at least one braking element (50) that can be displaced toward the at least one braking surface is arranged on the retainer housing (230), which the braking element can be brought in contact with the at least one braking surface of the door retainer rod at least in some sections and thus produces a primary braking force component against the displacement of the door retainer rod, wherein the door retainer rod has at least one guiding surface, which is inclined with respect to the braking surface.

Abstract: Described is a method for producing a multicoat color and/or effect paint system. A pigmented aqueous basecoat material is used which comprises at least one phosphite of the formula (I): wherein at least one of the radicals R1 to R3 is selected from the group of aliphatic hydrocarbons. The sum total of the weight percentage fractions of all of the phosphites of structural formula (I) here is 0.1% to 5% by weight, based on the total weight of the basecoat material used. Moreover, described are the corresponding basecoat materials, the corresponding multicoat color and/or effect paint system, and the use of the phosphites in pigmented aqueous coating materials. Also described is a method for repairing defects on multicoat color and/or effect paint systems produced with the aid of the above-identified method of the invention.

Abstract: The present invention relates to a domestic appliance, particularly a cooking oven, comprising a chassis and a door hinged to the chassis at a rotating axis of the door, wherein the door comprises at least one door panel, at least one door frame attached at an inner side of the door panel, at least one electric or electronic unit attached inside or at the door, at least one electrically conducting cable for interconnecting the electric or electronic unit to a control unit arranged at or in the chassis of the domestic appliance, at least one cable channel attached or attachable to the door frame for guiding a first section of the cable, and at least one cable tube arranged within the region of a rotating axis of the door for guiding a second section of the cable from the door frame to the chassis, wherein the cable tube comprises a main section, and a first end section for connecting the cable tube to the hinge-sided end of the door and a second end section for connecting the cable tube to the chassis, wherein

Abstract: Provided herein is a pigmented aqueous basecoat material including a hydroxy-functional polyether-based reaction product that is prepared by a urethane group-forming reaction of: (a) at least one component including isocyanate groups that is prepared by the urethane group-forming reaction of at least one organic diisocyanate (a1) with at least one polyether (a2) of the general structural formula (I). R is a C3 to C6 alkylene radical, and n is selected accordingly such that a polyether (b) possesses a number-average molecular weight of 500 to 5000 g/mol, the components (a1) and (a2) being used in a molar ratio of 1.8/1.7 to 3.0/1.0, and the resulting component (a) having an isocyanate content of 0.5 to 10.0% with (b) at least one organic polyol.

Abstract: A pigmented aqueous basecoat material that includes a dimer fatty acid/polyesterdiol reaction product which is preparable by reacting (a) dimer fatty acids with (b) at least one polyesterdiol of the general structural formula (I) where: R is a divalent radical including 2-10 carbon atoms; R1 and R2 are independently straight-chain or branched alkylene radicals having 2-10 carbon atoms; X and Y are independently O, S or NR3, where R3 is hydrogen or an alkyl radical having 1-6 carbon atoms; and m and n are selected accordingly such that the polyesterdiol possesses a number-average molecular weight of 450-2200 g/mol, components (a) and (b) are used in a molar ratio of 0.7/2.3 to 1.3/1.7, and the resulting dimer fatty acid/polyesterdiol reaction product possesses a number-average molecular weight of 1200-5000 g/mol and an acid number <10 mg KOH/g.

Abstract: The present invention relates to a method for producing a multicoat paint system on a metallic substrate, in which a basecoat or a plurality of directly successive basecoats are produced directly on a metallic substrate coated with a cured electrocoat, a clearcoat is produced directly on the one basecoat or the uppermost of the plurality of basecoats, and then the one or more basecoats and the clearcoat are jointly cured, and wherein at least one basecoat material used for production of the basecoats comprises at least one linear hydroxy-functional reaction product (R) having an acid number of less than 20 mg KOH/g, the preparation of which involves using at least one compound (v) containing two functional groups (v.1) and an aliphatic or araliphatic hydrocarbyl radical (v.2) which is arranged between the functional groups and has 12 to 70 carbons atoms.

Abstract: The present invention relates to a method for producing a multicoat paint system on a metallic substrate, in which a basecoat or a plurality of directly successive basecoats are produced directly on a metallic substrate coated with a cured electrocoat, a clearcoat is produced directly on the one basecoat or the uppermost of the plurality of basecoats, and then the one or more basecoats and the clearcoat are jointly cured, and wherein at least one basecoat material used for production of the basecoats comprises the following components: an aqueous dispersion comprising at least one specific copolymer, a specific linear hydroxy-functional reaction product and a polyurethane resin, the preparation of which involves using at least one compound containing at least one carboxylic acid group and at least one group reactive toward isocyanate groups.

Abstract: The present invention relates to a reaction product preparable by reacting (a) dimer fatty acids with (b) at least one compound (b) of the general structural formula (I) where R is a C3 to C6 alkylene radical and n correspondingly is selected such that the compound (b) possesses a number-average molecular weight of 120 to 445 g/mol, components (a) and (b) are used in a molar ratio of 0.7/2.3 to 1.6/1.7, and the resulting reaction product possesses a number-average molecular weight of 600 to 4000 g/mol and an acid number of less than 10 mg KOH/g. The invention further relates to a pigmented aqueous basecoat material which comprises this reaction product, and to the use of the reaction product in pigmented aqueous basecoat materials for improving adhesion. The present invention further relates to a method for producing multicoat paint systems, and also to the multicoat paint systems producible by means of said method.

Abstract: Described herein is a pigmented aqueous basecoat material including a polyether-based reaction product which is preparable by reaction of (a) at least one cyclic tetracarboxylic dianhydride having an aliphatic, aromatic, or araliphatic radical X bridging the two anhydride groups with (b) at least one polyether of the general structural formula (II) in which R is a C3 to C6 alkylene radical and n is selected accordingly such that the polyether (b) possesses a number-average molecular weight of 500 to 5000 g/mol, the components (a) and (b) being used in the reaction in a molar ratio of 0.7/2.3 to 1.6/1.7 and the resulting reaction product possessing an acid number of 5 to 80 mg KOH/g. Also described herein is a reaction product of specific dianhydrides and a polyether, and the use of the pigmented aqueous basecoat material or the reaction product.

Abstract: The present invention relates to a dimer fatty acid/dimer diol reaction product which is preparable by reacting (a) dimer fatty acids with (b) at least one dimer diol, where components (a) and (b) are used in a molar ratio of 0.7/2.3 to 1.3/1.7 and the resulting dimer fatty acid/dimer diol reaction product possesses a number-average molecular weight of 1200 to 5000 g/mol and an acid number <10 mg KOH/g. The invention further relates to a pigmented aqueous basecoat material which comprises this dimer fatty acid/dimer diol reaction product, and also to the use of said dimer fatty acid/dimer diol reaction product in pigmented aqueous basecoat materials. It relates, further, to a method for producing multicast paint systems, and also to the multicoat paint systems producible by means of said method. The present invention relates, furthermore, to the refinishing of defects on multicoat paint systems.

Abstract: A pigmented aqueous basecoat material is disclosed. The pigmented aqueous basecoat material includes a polyether-based reaction product which is preparable by a reaction of trimesic acid with at least one polyether of the general structural formula (I) R is a C3 to C6 alkylene radical and n is selected accordingly such that the at least one polyether possesses a number-average molecular weight of 500 to 5000 g/mol. The trimesic acid and the at least one polyether are used in the reaction in a molar ratio of 0.7/2.3 to 1.6/1.7 and the resulting reaction product possesses an acid number of 10 to 50 mg KOH/g.

Abstract: The present invention relates to a pigmented aqueous basecoat material comprising a polyether-based reaction product which is preparable by reaction of (a) at least one cyclic carboxylic anhydride comprising a free carboxylic acid group and/or the halide of a carboxylic acid group with (b) at least one polyether of the general structural formula (I) in which R is a C3 to C6 alkylene radical and n is selected accordingly such that the polyether (b) possesses a number-average molecular weight of 800 to 4000 g/mol, the components (a) and (b) being used in the reaction in a molar ratio of 0.7/2.3 to 1.6/1.7 and the resulting reaction product possessing an acid number of 10 to 50 mg KOH/g.

Abstract: The present invention relates to a pigmented aqueous basecoat material including a polyether-based reaction product which is preparable by reaction of (a) at least one carboxy-functional component which is preparable by esterification reaction of at least one dihydroxycarboxylic acid (a1) with at least one dicarboxylic acid (a2) and/or the anhydride of a dicarboxylic acid (a2), the components (a1) and (a2) being used in a molar ratio of 0.5/3.0 to 1.7/1.8, with (b) at least one polyether of a general structural formula (I) in which R is a C3 to C6 alkylene radical and n is selected accordingly such that the polyether (b) possesses a number-average molecular weight of 500 to 5000 g/mol, the components (a) and (b) being used in the reaction in a molar ratio of 0.7/2.3 to 1.6/1.7, and the resulting reaction product possessing an acid number of 10 to 50 mg KOH/g.

Abstract: A composition for fixing wound items is provided. In one example, the composition comprises 5 to 97 wt % of at least one ?,?-unsaturated polyester resin and/or ?,?-unsaturated polyester imide resin comprising components of at least one ?,?-ethylenically unsaturated mono-, di- and/or tricarboxylic acid, and/or its anhydride and/or ester, at least one polyol, at least one (meth)acrylic group containing component, possibly at least one mono-, di-, tri- and/or tetracarboxylic acid, which is not ?,?-ethylenically unsaturated, and/or its anhydride and/or ester.

Abstract: Described herein are sample manipulation devices, for removing lids from and/or for placing lids onto sample containers. Such devices include a sample unit including a sample carrier receptacle for receiving at least one sample carrier for holding one or more sample containers, and a manipulation unit having at least one manipulation tool, where the sample unit and the manipulation unit are movable relative to each other along a movement direction. The sample unit is also movable between a first orientation in which a longitudinal direction of a sample carrier in the sample carrier receptacle is parallel to the movement direction between sample unit and manipulation unit, and a second orientation in which a transverse direction, which is orthogonal to the longitudinal direction, of a sample carrier in the sample carrier receptacle is parallel to the movement direction between sample unit and manipulation unit.