Abstract: The present invention is based on a correlation found for the presence of the biomarker protein Cytotoxic T-lymphocyte protein 4, also known as CD152 or CTLA-4, on or in EVs, to their immunomodulatory efficacy. Hence, the invention provides a method for assessing the therapeutic efficacy of an EV or an EV-preparation by detecting the biomarker CTLA-4 in such EVs or EV-preparations. Furthermore, the invention provides a method for assessing the therapeutic efficacy of an EV or an EV-preparation by detecting at least one biomarker selected from the group of CTLA-4, PD1, PD-L1 and PD-L2 in the EV or EV-preparation. The method of the invention allows for an evaluation of the immunomodulatory efficacy of said EV preparations without the need of performing laborious functional in vivo or in vitro assays including mixed lymphocyte reaction assays. In three additional aspects of the invention, alternative methods for producing therapeutically active EVs or EV-preparations are provided.

Abstract: It is provided an adjustment system for adjusting an interior object in a vehicle interior, comprising at least—an adjustment apparatus for adjusting the interior object by means of external force and—control electronics for controlling the adjustment of the interior object by means of external force during an adjustment process starting from an initial position into a target position of the interior object. The control electronics are further designed to control the adjustment apparatus for the adjustment process in a first adjustment range for a rough adjustment of the interior object and in a subsequent second adjustment range from an intermediate position until the target position is reached for a precise adjustment.

Abstract: It is provided a drive apparatus for adjusting an interior assembly of a vehicle comprises an electromotive adjustment drive for producing an adjustment force, a self-locking adjustment kinematic mechanism for transmitting an adjustment force produced by the adjustment drive to the interior assembly, which adjustment kinematic mechanism can be driven by means of the adjustment drive, and a control device for controlling the adjustment drive. The control device is configured to activate an adjustment mode for adjustment of the interior assembly depending on at least one trigger criterion and, when the adjustment mode is activated, to actuate the adjustment drive with a support current of a magnitude such that the interior assembly can put into motion by means of a user force produced manually on the interior assembly by a user, overcoming the self-locking of the adjustment kinematic mechanism.

Abstract: A drive device for adjusting an interior assembly of a vehicle includes an electromotive adjustment drive configured to adjust the interior assembly and a controller configured to control the adjustment drive. The controller is further configured to control the adjustment drive in a servo operation for providing a supporting force during a manual adjustment of the interior assembly by a user.

Abstract: It is provided an adjustment system for a vehicle, comprising at least one electronic obstacle-detection device for detecting a potential obstacle in an adjustment path of the at least one interior component to be adjusted by an external force, wherein the at least one obstacle-detection device is configured to generate at least one obstacle signal on detection of a potential obstacle in the adjustment path, and control electronics which are configured to generate at least one control signal for outputting a visually perceptible obstacle indication for a user in response to the at least one obstacle signal, via which the potential obstacle is indicated.

Abstract: A measuring device for measuring parameters of a piezoelectric crystal onto which a thin film of material is deposited (under vacuum). The crystal includes two spaced-apart electrodes. A frequency generator is adapted to generate an oscillator signal at a specified output frequency. A measuring amplifier is adapted to apply the oscillator signal as a drive signal to one of the electrodes of the crystal and to provide a crystal output signal in response to the drive signal. A quadrature demodulator is adapted to down convert the crystal output signal and to provide an in-phase output signal and a quadrature output signal. A computation unit is adapted to determine one or more parameters of the crystal based on the in-phase output signal and the quadrature output signal. Furthermore, there is provided a corresponding measuring method as well as to thin-film deposition systems (including a vacuum chamber) with such a device and methods for controlling such systems.

Abstract: A control arrangement for a drive arrangement of a motor vehicle interior element, the interior element is adjustable and lockable in position by aid of adjustment kinematics, the drive arrangement configured to adjust the interior element with the aid of adjustment kinematics and an interior sensor arrangement for detecting an object, the control arrangement activates the drive in an adjustment routine to adjust the interior element in a rotational motion from an initial angle to a terminal angle. The control arrangement activates the adjustment routine based on sensor data for the object, acquired by means of the interior sensor. The control arrangement includes an interior-element model of geometry of the interior element and the adjustment kinematics and generates a geometric object model based on the sensor data, to determine the terminal angle based on the interior-element model and the object model, adhering to a separation specification.

Abstract: A hydraulic control loop controls a hydraulic adjusting cylinder. The cylinder has a cylindrical housing and a displaceable piston therein. The piston divides the housing interior into a first and a second hydraulic chamber. A first hydraulic valve supplies the first hydraulic chamber with hydraulic fluid. A hydraulic pressure of the first hydraulic chamber is adjustable by controlling the first hydraulic valve. A second hydraulic valve supplies the second hydraulic chamber with hydraulic fluid. A hydraulic pressure of the second hydraulic chamber is adjustable by controlling the second hydraulic valve. A control device controls the two hydraulic valves. In a position control state, the second hydraulic valve is controlled by a position control signal dependent on the working position of the piston and the first hydraulic valve is controlled by an adjusted position control signal, that is generated on the basis of the position control signal.

Abstract: The lifting platform (10) has at least two lateral pillars (12, 14, 33). Each pillar has height-changeable, pivotable arms (13, 34, 44) that are displaceable telescopically in length. An end of each arm has a decoupling device with a receptacle (31, 41) for supporting an object. A carrying device (11, 50) has receiving points corresponding to the number of the receptacles (31, 41). The lifting platform and the carrying device are positioned with respect to each other without impairing an object resting on the at least one receptacle. The at least one receptacle (31, 41) is placed onto the at least one receiving point, and the carrying device (11, 50) together with the transferred at least one receptacle (31, 41) and an object thereon is removed from a region of the lifting platform (10).

Abstract: A hydraulic control loop controls a hydraulic adjusting cylinder. The cylinder has a cylindrical housing and a displaceable piston therein. The piston divides the housing interior into a first and a second hydraulic chamber. A first hydraulic valve supplies the first hydraulic chamber with hydraulic fluid. A hydraulic pressure of the first hydraulic chamber is adjustable by controlling the first hydraulic valve. A second hydraulic valve supplies the second hydraulic chamber with hydraulic fluid. A hydraulic pressure of the second hydraulic chamber is adjustable by controlling the second hydraulic valve. A control device controls the two hydraulic valves. In a position control state, the second hydraulic valve is controlled by a position control signal dependent on the working position of the piston and the first hydraulic valve is controlled by an adjusted position control signal, that is generated on the basis of the position control signal.

Abstract: The invention relates to a method for activating motors of a massage device provided in a seat, in particular a vehicle seat, wherein the activation of the motors is performed by a control unit on the basis of an acoustic entertainment signal, wherein a first motor and a second motor are activated as a pair, and wherein the activation of the motors of the pair is performed alternately. The invention further relates to a control unit, which is designed to control at least one pair of motors according to a method according to the invention, and to a seat arrangement for carrying out such a method.

Abstract: A chair includes a seat surface and a laterally pivotable backrest. The backrest is secured to two joints, which have mutually parallel axes of rotation.

Abstract: The invention relates to a chair, in particular an office chair, comprising a seat surface and a laterally pivotable backrest, wherein the backrest is secured to two joints, which have mutually parallel axes of rotation.

Abstract: An ancillary unit of a motor vehicle, which may particularly be a massage device for a vehicle seat, includes an electrically conductive housing and a planar printed circuit board. A narrow side of the printed circuit board has an electrically conductive section, which is brought into electrical contact with the housing.

Abstract: A device for measuring the tension in a tensioning belt comprises a retaining device for retaining a spring element, an elastically deformable spring element that is retained by the retaining device and on which a section of the tensioning belt can apply a force and elastically deform the spring element, the ends of the spring element being moved closer to one another when the tensioning force increases, and an electronic sensor unit. The sensor unit comprises a sensor system that measures the deflection of the spring element and generates a data signal, and a transmitter for transmitting the data signal to a receiving unit. The sensor system is situated at the ends of the spring element.

Abstract: A method for operating an electromotive massage device of a seat, in particular of a motor vehicle, comprising a massage drive having an electric motor. The electric motor is energized, and a torque of the electric motor is detected, and a first reference value is calculated therefrom. Based on the first reference value, the occupancy of at least one section of the seat is determined. An electromotive massage device of a seat and a seat of a motor vehicle are also provided.

Abstract: The lifting platform (10) has at least two lateral pillars (12, 14, 33). Each pillar has height-changeable, pivotable arms (13, 34, 44) that are displaceable telescopically in length. An end of each arm has a decoupling device with a receptacle (31, 41) for supporting an object. A carrying device (11, 50) has receiving points corresponding to the number of the receptacles (31, 41). The lifting platform and the carrying device are positioned with respect to each other without impairing an object resting on the at least one receptacle. The at least one receptacle (31, 41) is placed onto the at least one receiving point, and the carrying device (11, 50) together with the transferred at least one receptacle (31, 41) and an object thereon is removed from a region of the lifting platform (10).

Abstract: The adjusting mechanism serves for the setting of a restoring force acting on the backrest of a chair. A back support and a seat support are fastened on a support. A setting mechanism configured in the manner of scissors is provided for the weight setting. Said setting mechanism has two scissor arms which are connected to one another via a scissor pin. One of said scissor arms is formed by a spring element and is fastened with its front-side spring end on said support. The back spring end is fastened on said scissor pin. Said first scissor arm is connected to said back support in the manner of a connecting rod. An active lever length is defined between said scissor pin and a support pin about which said back support is mounted pivotably. A compact construction mode is achieved by the configuration of said scissor arm as a spring element.

Abstract: The present invention relates to the use of exosome-preparations derived from neonatal or adult tissue-derived mesenchymal stem-cells (MSCs) for the prevention or for therapy of inflammatory conditions, such as, for example, pre- and postnatally acquired damages of the brain (i.e. neuronal damages) or in complications following stem cell transplantation (“graft vs host-disease”, GvHD).

Abstract: The invention relates to a device for measuring the tension in a tensioning belt, comprising a retaining device for retaining a spring element, an elastically deformable spring element that is retained by the retaining device and on which a section of the tensioning belt can apply a force and elastically deform the spring element, the ends of the spring element being moved closer to one another when the tensioning force increases, and an electronic sensor unit. The sensor unit comprises a sensor system that measures the deflection of the spring element and generates a data signal, and a transmitter for transmitting the data signal to a receiving unit. The sensor system is situated at the ends of the spring element.