Abstract: An electronic capacity exchange system comprises one or more computing devices in communication with one another via at least one of a wired and wireless network. In one aspect, the system is configured to receive capacity orders for product and/or service capacity that include an associated order value in terms of non-monetary universal trading units (UTU's). In addition, the system receives at least electronic indication of interests, at least one of which corresponds to at least one capacity order. The indication of interest is compared to its corresponding capacity order and if there is a match, a capacity may be consummated and executed. Upon execution of the capacity transaction, a quantity of UTU's is credited and/or debited from electronic UTU accounts pertaining to one or both parties to the capacity transaction.

Abstract: Anti-viral agents of Formula (Ia) wherein: A represents hydroxy; D represents 4-tert-butyl-3-methoxyphenyl; E represents 1,3-thiazol-2-yl or 5-methyl-1,3-thiazol-2-yl,; G represents methoxymethyl; J represents 1,3-thiazol-2-ylmethyl, 1,3-thiazol-4-ylmethyl, 1,2-thiazol-3-ylmethyl, or 1H-pyrazol-1-ylmethyl; and salts, solvates and esters thereof; provided that when A is esterified to form —OR where R is selected from straight or branched chain alkyl, aralkyl, aryloxyalkyl, or aryl, then R is other than tert-butyl; processes for their preparation and their use in HCV treatment are provided.

Abstract: Anti-viral agents of Formula (I) wherein: A represents hydroxy; D represents aryl or heteroaryl; E represents hydrogen, C1-6alkyl, aryl, heteroaryl or heterocyclyl; G represents hydrogen or optionally substituted C1-6alkyl; J represents C1-6alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; and salts, solvates and esters thereof; provided that when A is esterified to form —OR where R is selected from straight or branched chain alkyl, aralkyl, aryloxyalkyl, or aryl, then R is other than tert-butyl; processes for their preparation, pharmaceutical compositions comprising them, and methods of using them in HCV treatment are provided.

Abstract: The invention relates to anti-viral agents of Formula (I) wherein: RA represents OR1, NR1R2, or R1 wherein R1 and R2 independently represent hydrogen, C1-6alkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl; or R1 and R2 together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; RB represents C(O)R3 wherein R3 represents aryl or heteroaryl; RC represents C1-6alkyl, aryl, heteroaryl or heterocyclyl; RD represents hydrogen and RE represents hydrogen, OR4 or SR4, or RD and RE together with the carbon atom to which they are attached form a carbonyl group or a thiocarbonyl group; when RE is hydrogen, OR4 or SR4, RG and RH are both hydrogen; when RD and RE together with the carbon atom to which they are attached form a carbonyl group or a thiocarbonyl group, RG represents hydrogen and RH represents hydrogen, OR4 or SR4, or RG and RH together with the carbon atom to which they are attached form a carbonyl group or a thiocarbonyl group; R4 represents hydroge

Abstract: Novel anti-viral agents of Formula wherein: A represents OR1, NR1R2, or R1 wherein R1 and R2 are hydrogen, C1-6alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; or R1 and R2 together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; B represents C(O)R3 wherein R3 is C1-6alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; C represents C1-6alkyl, aryl, heteroaryl or heterocyclyl; D represents a saturated or unsaturated optionally substituted 6-membered heterocyclic ring; E represents hydrogen or C1-6-alkyl; F represents hydrogen, C1-6alkyl, aryl or heteroaryl; and G represents hydrogen, C1-6alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; and salts, solvates and esters thereof, processes for their preparation and methods of using them in HCV treatment are provided.

Abstract: Protide compounds of formula (I) wherein X represents H, F, N3, NH2, —CN, or —OMe; X1 represents O or NR7; X2 represents O, NH, NR6 or S, or when X3 is O then X2 is absent; X3 is absent, or when X1 is O then X3 represents O; R1 represents hydrogen; optionally substituted C1-6alkyl; optionally substituted aryl; or optionally substituted heteroaryl; R2 represents hydroxy, OCOR6, or OCO2R6; R3 represents H, optionally substituted C1-6alkyl, optionally substituted aryl, optionally substituted heteroaryl or optionally substituted heterocyclyl; R4 and R5 are independently selected from hydrogen, optionally substituted C1-6alkyl, optionally substituted aryl, or optionally substituted aralkyl; R6 represents optionally substituted C1-6alkyl or optionally substituted aryl; R7 represents H, optionally substituted C1-6alkyl, or optionally substituted aryl, wherein when R4 and R7 are each alkyl they may be linked to form a 5- or 6-membered ring; B represents (a), (b), (c), or (d) wherein Z represents O or S; R8

Abstract: Novel anti-viral agents of Formula (I) wherein: A represents OR1, NR1R2, or R1 wherein R1 and R2 are hydrogen, C1-6alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; or R1 and R2 together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; B represents C(O)R3 wherein R3 is C1-6alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; D represents C1-6alkyl, aryl, heteroaryl or heterocyclyl; E represents OR1, NR1R2, or R1 wherein R1 and R2 are hydrogen, C1-6alkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl; or R1 and R2 together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; F represents hydrogen, C1-6alkyl, aryl or heteroaryl; and G represents hydrogen, C1-6alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; and salts and solvates thereof, processes for their preparation and methods of using them in HCV treatment are provided.

Abstract: A Web-based system and method for selectively reproducing software files for distribution to a user, to support that user's already authorized and installed software applications includes a web server, a database containing a selection of software files, a graphical user interface (GUI) for accessing the database remotely by an authorized subscriber of one or more subsets of the software files, a GUI for searching the database to determine what, if any, additional software files are available to the authorized subscriber, a GUI for displaying the results of such search, a GUI for selecting software files to be reproduced and delivered to the authorized subscriber, means for reproducing such selected software in a computer readable medium, and means for coordinating the shipment of that computer readable medium to the authorized subscriber for the purposes of updating, upgrading, and installing new revisions of the software applications of a client device operated by such authorized subscriber.

Abstract: The present invention relates to the specific stimulation of serum and secretory antibodies through mucosal presentation of antigens.

Abstract: Compounds of formula (I), ##STR1## wherein R.sup.1 represents OR.sup.5, SR.sup.5, NR.sup.5 R.sup.6, N(OR.sup.5)R.sup.6 or N(NR.sup.5 R.sup.6)R.sup.6 ; X represents OH, N.sub.3, NR.sup.3 R.sup.4 or NR.sup.4 CO.sub.2 R.sup.15 ; Y represents H or NHR.sup.2 ; R.sup.2 represents a group SO.sub.2 R.sup.7 or COR.sup.7 ; R.sup.3 represents H, C.sub.1-6 alkyl or C(.dbd.NR.sup.8)NR.sup.9 R.sup.10 ; R.sup.4 represents H or C.sub.1-6 alkyl; R.sup.5 represents H, C.sub.1-20 alkyl, C.sub.3-8 cycloalkyl, C.sub.2-20 alkenyl, C.sub.2-20 alkynyl, CHR.sup.11 COR.sup.12 or C.sub.1-20 alkyl substituted by one or more groups selected from NR.sup.13 R.sup.14, NR.sup.13 COR.sup.14, CO.sub.2 R.sup.13, OR.sup.13, C.sub.3-8 cycloalkyl and optionally substituted aryl; each R.sup.6 independently represents H, C.sub.1-6 alkyl, C.sub.3-8 cycloalkyl, C.sub.2-6 alkenyl, C.sub.2-20 alkynyl, aryl or C.sub.1-4 alkyl substituted by one or more groups selected from NR.sup.13 R.sup.14, COR.sup.13, C.sub.3-8 cycloalkyl, CN, N.sub.3, OR.sup.

Abstract: Complex of a drug, hormone, bio-active peptide, or immunogen with the carrier molecule vitamin B12 and a method for delivering the complex to the intestine of a host vertebrate in order to deliver the complex to the circulation of the host and thereby elicit a pharmacological response to the drug, hormone, bio-active molecule or to elicit a systemic immune response to the immunogen. The invention also provides a method for the production of the complex. Further, the invention provides medicaments containing the complex.

Abstract: Complex of a drug, hormone, bio-active peptide, or immunogen with the carrier molecule vitamin B12 and a method for delivering the complex to the intestine of a host vertebrate in order to deliver the complex to the circulation of the host and thereby elicit a pharmacological response to the drug, hormone, bio-active molecule or to elicit a systemic immune response to the immunogen. The invention also provides a method for the production of the complex. Further, the invention provides medicaments containing the complex.

Abstract: An orally administered complex of a drug, hormone, bio-active peptide, or immunogen with the carrier molecule, such as vitamin B12 or analogue thereof, and a method for delivering said complex to the intestine of a host vertebrate in order to deliver the complex to the circulation of the host and thereby elicit a pharmacological response to the drug, hormone, or bio-active molecule or to elicit a systemic immune response to the immunogen. The invention also provides a method for the production of the complex. Further the invention provides medicaments containing the complex.

Abstract: A folding freight carrier consists of a flat rectangular base structure, whose upper surface forms a loading bearing freight carrying platform, having post members pivotally mounted on the base structure at each corner thereof, said post members are capable of being moved from an erected position in which the post extends upwardly from the base structure to a folded position in which the post members lie parallel to the base structure. The base structure is provided adjacent its corners with recesses into which the post members are located when in their folded position so that the post members do not project above the freight carrying platform but rather form a continuation of the load bearing freight carrying platform.

Abstract: A fuel injection nozzle of the outwardly opening type includes a valve member having a head biased into contact with a seating by a coiled spring. Fuel under pressure applied to the valve member lifts the head from the seating to allow fuel flow through an outlet. The valve member has a spring retainer connected to it and which forms a piston slidable in a skirt member which forms a cylinder into and out of which fuel can flow through a port. The port is positioned to be progressively covered by the retainer member to form a hydraulic spring which assists the action of the coiled spring, as the valve head is lifted from the seating.

Abstract: A fuel injection pumping apparatus of the rotary distributor type includes a cam ring the angular setting of which can be adjusted to determine the timing of delivery of fuel. In order to adjust the setting of the cam ring first and second fluid pressure operable pistons are arranged in parallel side by side relationship and are each coupled to the cam ring by a radial arm. The first piston is subject to a speed dependent pressure generated within the apparatus to provide normal speed advance and the second piston under the control of a valve can be subjected to said pressure to give full advance when the associated engine is cold and up to a predetermined engine load.

Abstract: A fuel injection pump of the rotary distributor type includes a cam actuated plunger housing in a bore and an adjustable fuel control member which varies the amount of fuel supplied to the bore. The pump also includes a timing piston connected to the cam, the piston being biased by a spring against the action of fuel under pressure. In order to vary the timing under certain conditions a control piston serves as an abutment for the spring and the application of pressure to the control piston is controlled by a valve which has a valve element coupled to a throttle member of the pump the valve having a housing which is secured on the exterior of the pump.

Abstract: A fuel injection nozzle includes a valve assembly located within a chamber defined in a body part to which fuel is supplied through an inlet. The wall of the chamber is resilient whereby during the initial delivery of fuel to the injection nozzle the wall deflects to store fuel whereby the initial rate of flow of fuel to the engine will be at a reduced rate.

Abstract: An internal combustion engine performance analyzing system is disclosed for displaying a number of operating characteristics, such as engine ignition and cylinder power, which exists under selectively controlled operating conditions. Simple connections to the engine provide the necessary signals to the solid-state electronic analyzer. Various pattern display modes may be selected. An anticipatory cylinder fire signal, which is related to crankshaft rotational degrees, permits a given cylinder to be shorted for the desired interval, regardless of the engine speed. This anticipatory cylinder fire signal is obtained from a servoed ramp waveform generator. Individual cylinder waveform patterns are synchronously and simultaneously displayed on an oscilloscope.