Abstract: A cartridge for a laundry appliance includes an outer housing having an interior chamber therein. The outer housing includes a primary axis and a secondary axis that is perpendicular to the primary axis. A pump is contained within the outer housing that selectively delivers a laundry chemistry from the interior chamber to a dispensing outlet of the outer housing. The dispensing outlet is defined within a contoured edge of the outer housing and orients the dispensing outlet at an oblique angle with respect to the primary and secondary axes. A rotational drive is operated by an external actuator. The rotational drive is positioned within the outer housing and in operable communication with the pump. The rotational drive aligns with a drive aperture defined within a wall of the outer housing for receiving the external actuator.

Abstract: A cartridge for a laundry appliance includes an outer housing having an interior chamber therein. The outer housing includes a primary axis and a secondary axis that is perpendicular to the primary axis. A pump is contained within the outer housing that selectively delivers a laundry chemistry from the interior chamber to a dispensing outlet of the outer housing. The dispensing outlet is defined within a contoured edge of the outer housing and orients the dispensing outlet at an oblique angle with respect to the primary and secondary axes. A rotational drive is operated by an external actuator. The rotational drive is positioned within the outer housing and in operable communication with the pump. The rotational drive aligns with a drive aperture defined within a wall of the outer housing for receiving the external actuator.

Abstract: A cartridge for a laundry appliance includes an outer housing having an interior chamber therein. The outer housing includes a primary axis and a secondary axis that is perpendicular to the primary axis. A pump is contained within the outer housing that selectively delivers a laundry chemistry from the interior chamber to a dispensing outlet of the outer housing. The dispensing outlet is defined within a contoured edge of the outer housing and orients the dispensing outlet at an oblique angle with respect to the primary and secondary axes. A rotational drive is operated by an external actuator. The rotational drive is positioned within the outer housing and in operable communication with the pump. The rotational drive aligns with a drive aperture defined within a wall of the outer housing for receiving the external actuator.

Abstract: Anti-viral agents of Formula (Ia) wherein: A represents hydroxy; D represents 4-tert-butyl-3-methoxyphenyl; E represents 1,3-thiazol-2-yl or 5-methyl-1,3-thiazol-2-yl,; G represents methoxymethyl; J represents 1,3-thiazol-2-ylmethyl, 1,3-thiazol-4-ylmethyl, 1,2-thiazol-3-ylmethyl, or 1H-pyrazol-1-ylmethyl; and salts, solvates and esters thereof; provided that when A is esterified to form —OR where R is selected from straight or branched chain alkyl, aralkyl, aryloxyalkyl, or aryl, then R is other than tert-butyl; processes for their preparation and their use in HCV treatment are provided.

Abstract: Anti-viral agents of Formula (I) wherein: A represents hydroxy; D represents aryl or heteroaryl; E represents hydrogen, C1-6alkyl, aryl, heteroaryl or heterocyclyl; G represents hydrogen or optionally substituted C1-6alkyl; J represents C1-6alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; and salts, solvates and esters thereof; provided that when A is esterified to form —OR where R is selected from straight or branched chain alkyl, aralkyl, aryloxyalkyl, or aryl, then R is other than tert-butyl; processes for their preparation, pharmaceutical compositions comprising them, and methods of using them in HCV treatment are provided.

Abstract: The invention relates to anti-viral agents of Formula (I) wherein: RA represents OR1, NR1R2, or R1 wherein R1 and R2 independently represent hydrogen, C1-6alkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl; or R1 and R2 together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; RB represents C(O)R3 wherein R3 represents aryl or heteroaryl; RC represents C1-6alkyl, aryl, heteroaryl or heterocyclyl; RD represents hydrogen and RE represents hydrogen, OR4 or SR4, or RD and RE together with the carbon atom to which they are attached form a carbonyl group or a thiocarbonyl group; when RE is hydrogen, OR4 or SR4, RG and RH are both hydrogen; when RD and RE together with the carbon atom to which they are attached form a carbonyl group or a thiocarbonyl group, RG represents hydrogen and RH represents hydrogen, OR4 or SR4, or RG and RH together with the carbon atom to which they are attached form a carbonyl group or a thiocarbonyl group; R4 represents hydroge

Abstract: Novel anti-viral agents of Formula wherein: A represents OR1, NR1R2, or R1 wherein R1 and R2 are hydrogen, C1-6alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; or R1 and R2 together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; B represents C(O)R3 wherein R3 is C1-6alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; C represents C1-6alkyl, aryl, heteroaryl or heterocyclyl; D represents a saturated or unsaturated optionally substituted 6-membered heterocyclic ring; E represents hydrogen or C1-6-alkyl; F represents hydrogen, C1-6alkyl, aryl or heteroaryl; and G represents hydrogen, C1-6alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; and salts, solvates and esters thereof, processes for their preparation and methods of using them in HCV treatment are provided.

Abstract: Novel anti-viral agents of Formula (I) wherein: A represents OR1, NR1R2, or R1 wherein R1 and R2 are hydrogen, C1-6alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; or R1 and R2 together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; B represents C(O)R3 wherein R3 is C1-6alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; D represents C1-6alkyl, aryl, heteroaryl or heterocyclyl; E represents OR1, NR1R2, or R1 wherein R1 and R2 are hydrogen, C1-6alkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl; or R1 and R2 together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; F represents hydrogen, C1-6alkyl, aryl or heteroaryl; and G represents hydrogen, C1-6alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; and salts and solvates thereof, processes for their preparation and methods of using them in HCV treatment are provided.

Abstract: Protide compounds of formula (I) wherein X represents H, F, N3, NH2, —CN, or —OMe; X1 represents O or NR7; X2 represents O, NH, NR6 or S, or when X3 is O then X2 is absent; X3 is absent, or when X1 is O then X3 represents O; R1 represents hydrogen; optionally substituted C1-6alkyl; optionally substituted aryl; or optionally substituted heteroaryl; R2 represents hydroxy, OCOR6, or OCO2R6; R3 represents H, optionally substituted C1-6alkyl, optionally substituted aryl, optionally substituted heteroaryl or optionally substituted heterocyclyl; R4 and R5 are independently selected from hydrogen, optionally substituted C1-6alkyl, optionally substituted aryl, or optionally substituted aralkyl; R6 represents optionally substituted C1-6alkyl or optionally substituted aryl; R7 represents H, optionally substituted C1-6alkyl, or optionally substituted aryl, wherein when R4 and R7 are each alkyl they may be linked to form a 5- or 6-membered ring; B represents (a), (b), (c), or (d) wherein Z represents O or S; R8

Abstract: Compounds of formula (I), ##STR1## wherein R.sup.1 represents OR.sup.5, SR.sup.5, NR.sup.5 R.sup.6, N(OR.sup.5)R.sup.6 or N(NR.sup.5 R.sup.6)R.sup.6 ; X represents OH, N.sub.3, NR.sup.3 R.sup.4 or NR.sup.4 CO.sub.2 R.sup.15 ; Y represents H or NHR.sup.2 ; R.sup.2 represents a group SO.sub.2 R.sup.7 or COR.sup.7 ; R.sup.3 represents H, C.sub.1-6 alkyl or C(.dbd.NR.sup.8)NR.sup.9 R.sup.10 ; R.sup.4 represents H or C.sub.1-6 alkyl; R.sup.5 represents H, C.sub.1-20 alkyl, C.sub.3-8 cycloalkyl, C.sub.2-20 alkenyl, C.sub.2-20 alkynyl, CHR.sup.11 COR.sup.12 or C.sub.1-20 alkyl substituted by one or more groups selected from NR.sup.13 R.sup.14, NR.sup.13 COR.sup.14, CO.sub.2 R.sup.13, OR.sup.13, C.sub.3-8 cycloalkyl and optionally substituted aryl; each R.sup.6 independently represents H, C.sub.1-6 alkyl, C.sub.3-8 cycloalkyl, C.sub.2-6 alkenyl, C.sub.2-20 alkynyl, aryl or C.sub.1-4 alkyl substituted by one or more groups selected from NR.sup.13 R.sup.14, COR.sup.13, C.sub.3-8 cycloalkyl, CN, N.sub.3, OR.sup.

Abstract: A fuel injection nozzle of the outwardly opening type includes a valve member having a head biased into contact with a seating by a coiled spring. Fuel under pressure applied to the valve member lifts the head from the seating to allow fuel flow through an outlet. The valve member has a spring retainer connected to it and which forms a piston slidable in a skirt member which forms a cylinder into and out of which fuel can flow through a port. The port is positioned to be progressively covered by the retainer member to form a hydraulic spring which assists the action of the coiled spring, as the valve head is lifted from the seating.

Abstract: A fuel injection pumping apparatus of the rotary distributor type includes a cam ring the angular setting of which can be adjusted to determine the timing of delivery of fuel. In order to adjust the setting of the cam ring first and second fluid pressure operable pistons are arranged in parallel side by side relationship and are each coupled to the cam ring by a radial arm. The first piston is subject to a speed dependent pressure generated within the apparatus to provide normal speed advance and the second piston under the control of a valve can be subjected to said pressure to give full advance when the associated engine is cold and up to a predetermined engine load.

Abstract: A fuel injection pump of the rotary distributor type includes a cam actuated plunger housing in a bore and an adjustable fuel control member which varies the amount of fuel supplied to the bore. The pump also includes a timing piston connected to the cam, the piston being biased by a spring against the action of fuel under pressure. In order to vary the timing under certain conditions a control piston serves as an abutment for the spring and the application of pressure to the control piston is controlled by a valve which has a valve element coupled to a throttle member of the pump the valve having a housing which is secured on the exterior of the pump.

Abstract: A fuel injection nozzle includes a valve assembly located within a chamber defined in a body part to which fuel is supplied through an inlet. The wall of the chamber is resilient whereby during the initial delivery of fuel to the injection nozzle the wall deflects to store fuel whereby the initial rate of flow of fuel to the engine will be at a reduced rate.