Abstract: Described herein is a 3D-printed scaffold comprising a peptide-polymer conjugate, the peptide-polymer conjugate having the structure: X—Y-Z-Y—X, wherein X is a biologically active peptide, Y is a linker moiety, and Z is a biocompatible and biodegradable polymer.

Abstract: The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

Abstract: The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

Abstract: A system for providing continuous positive air pressure therapy is provided. The system includes a patient interface, a flow generator, a sensor, and a computing device. Wireless transceivers allow wireless communication between the computing device and the flow generator and/or patient interface. Sensor data is communicated to the computing device and a leak determination is made by the computing device based on the sensor data. If a leak is detected, then troubleshooting options for correcting the leak are displayed to the patient on a display of the computing device. The troubleshooting options may be selected based on the sensed data, the type of patient interface, the type of flow generator, or characteristics of the patient using the device.

Abstract: The present invention relates to immunoglobulin new antigen receptors (IgNARs) from fish and uses thereof. In particular, the present invention relates to modified IgNAR variable domains and to domains from members of the immunoglobulin superfamily that have been modified to include structural features derived from IgNAR variable domains.

Abstract: A user device for connecting symptom, disease, procedure, and facility based information into actionable services for medical care and cost analysis is presented. The user device may include the functionality of linking medical information and providing user specific information. The user-specific information allows the user to make an informed decision about medical treatment. The user device may further be operative to tailor information in light of user characteristics such as location or healthcare network membership.

Abstract: Systems and method for communication of information to one or more medical care providers. The systems and methods may utilize a client with which a user may interact. As such, the user may utilize the client to research, display, and/or select a medical care provider. The user may input information to the client which is transmitted to a selected medical care provider prior to the user arriving at the medical care provider's facility. This may include an indication of the user's intent to visit the medical care provider. As such, the medical care provider may utilize the data received to generate a chart and make preparations (e.g., reserve resources) in anticipation of the user's visit. The user may also use the client to access and/or share a personal health record.

Abstract: A user device for connecting symptom, disease, procedure, and facility based information into actionable services for medical care and cost analysis is presented. The user device may include the functionality of linking medical information and providing user specific information. The user-specific information allows the user to make an informed decision about medical treatment. The user device may further be operative to tailor information in light of user characteristics such as location or healthcare network membership.

Abstract: A method of manufacturing an upper made of a composite material for an article of footwear is disclosed. The method includes associating a layer of carbon fiber material and a flexible substrate to form the composite material. A thin outer coating of TPU is applied to an outer surface of the carbon fiber material of the composite material. The method forms an article of footwear having an upper that is generally flexible and lightweight.

Abstract: A method of manufacturing an upper made of a composite material for an article of footwear is disclosed. The method includes associating a layer of carbon fiber material and a flexible substrate to form the composite material. A thin outer coating of TPU is applied to an outer surface of the carbon fiber material of the composite material. The method forms an article of footwear having an upper that is generally flexible and lightweight.

Abstract: An upper made of a composite material is disclosed. The composite material comprises a layer of carbon fiber material and a flexible substrate. The composite material also includes a thin outer coating of TPU. The upper is generally flexible and lightweight.

Abstract: The present invention concerns compounds inter alia according to general formula 1a. Compounds according to the invention are vasopressin V1a receptor antagonists. Pharmaceutical compositions of the compounds are useful as treatment of dysmenorrhoea.

Abstract: The present invention concerns compounds inter alia according to general formula 1a. Compounds according to the invention are vasopressin V1a receptor antagonists. Pharmaceutical compositions of the compounds are useful as treatment of dysmenorrhoea.

Abstract: The present invention relates to immunoglobulin new antigen receptors (IgNARs) from fish and uses thereof. In particular, the present invention relates to modified IgNAR variable domains and to domains from members of the immunoglobulin superfamily that have been modified to include structural features derived from IgNAR variable domains.

Abstract: The present invention relates to immunoglobulin new antigen receptors (IgNARs) from fish and uses thereof. In particular, the present invention relates to modified IgNAR variable domains and to domains from members of the immunoglobulin superfamily that have been modified to include structural features derived from IgNAR variable domains.

Abstract: A cleated article of footwear includes a chassis assembly having a sole plate having a plurality of bosses extending from a lower surface thereof. A heel counter extends upwardly from a heel portion of the sole plate. An outer assembly is secured to the chassis assembly and includes a sole portion and an upper secured to the sole portion. A plurality of cleats extends downwardly from a lower surface of the sole portion. Each of a plurality of apertures extends downwardly into a corresponding cleat and receives a boss.

Abstract: An upper made of a composite material is disclosed. The composite material comprises a layer of carbon fiber material and a flexible substrate. The composite material also includes a thin outer coating of TPU. The upper is generally flexible and lightweight.

Abstract: An upper made of a composite material is disclosed. The composite material comprises a layer of carbon fiber material and a flexible substrate. The composite material also includes a thin outer coating of TPU. The upper is generally flexible and lightweight.

Abstract: A rotatable selector mechanism for a motor vehicle transmission has a selector knob rotatable in a housing to select an operating mode of the transmission among a number of selector positions indicated by a label (P, R, N, D, M). The selector mechanism further includes a detent plate which cooperates with a detent pin for maintaining the selector knob in each of positions. The detent plate is connected to position sensors for generating selector signals to a transmission control unit which supplies control signals to an actuator for operate the transmission according to the operating mode selected. The detent plate is also associated to the selector knob and to a drive correction means by means of clutch devices respectively to engage the detent plate to one of the selector knob and the drive correction means.

Abstract: A computer-based graphical user interface for graphically controlling processing of hydrological data, comprising a display menu interface listing executable tools from the group comprising one or more of: hydrological data input, hydrological data validity checking and correction, and hydrological modeling, a GUI for selecting and arranging tools from the display menu in a graphical display area to construct a hydrological process, the selected tools each being represented by icons on the graphical display, and for establishing a connection between at least one output of a first tool and an input of a second tool said tools by graphically displaying the connection between said tools representative icon and input means for receiving user input to arrange and execute said constructed hydrological data processing process.