Abstract: A compound of Formula I or a hydrate or solvate thereof, where R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Abstract: The present invention relates to compounds of formula (I) wherein X, R1, R2, R3, R4 and R5 are as defined herein, which are useful for treating diseases which respond to CXCR2 receptor mediators. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Abstract: A debug circuit for a multi-mode circuit driven by a clock signal, with an input for a clock signal, and a debug signal generator arranged to generate for each of a subset of the modes of the multi-mode circuit a corresponding debug signal based on a clock signal provided at the input. The frequency of debug signals is dependent on the frequency of a clock signal provided at the input, and each debug signal selects its respective mode for a length of time longer than that of each other mode of the multi-mode circuit, or each debug signal selects its respective mode for a length of time shorter than that of each other mode of the multi-mode circuit.

Abstract: Address Resolution Protocol (ARP) request mirroring can provide a mechanism for synchronizing link-layer adjacency information among network elements. This application can be useful, for example, for internet protocol (IP) routing network elements in a high-availability configuration.

Abstract: In various embodiments, one or more real musical instruments may be used to interact with a program (e.g., a game or learning application) on a digital device such as a game console. A method may comprise receiving a music signal from a port of a real musical instrument, formatting the music signal for transmission to a digital device, wherein the formatted music signal comprises an instrument identifier, and wirelessly transmitting the formatted music signal.

Abstract: Compounds of formula (I) in free or salt or solvate form, where T1, T2, and T3 have the meanings as indicated in the specification, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pulmonary fibrosis, liver fibrosis, muscle diseases and systemic skeletal disorders. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Abstract: Compounds of formula (I) inhibit microtubule affinity regulating kinase (MARK), and hence are suitable for treating diseases associated with abnormal phosphorylation of tau.

Abstract: Method and system for forming one or more predetermined patterns on a substrate for making a photovoltaic device. The method includes aligning at least a first droplet source with a substrate, dispensing one or more first droplets associated with one or more first materials from the first droplet source, and forming at least a first pattern of one or more second materials on the substrate by at least the first droplet source. Additionally, the method includes providing a first light beam incident on at least the first pattern, obtaining a first signal associated with the first pattern in response to the first light beam, processing information associated with the first signal, and determining one or more first characteristics of the first pattern based on at least information associated with the first signal.

Abstract: The present invention relates to compounds of formula (I) and the use of these compounds as pharmaceuticals, e.g. in preventing or treating a CXCR2 receptor mediated condition or disease.

Abstract: A compound of Formula I in free or salt or solvate form, where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Abstract: The present invention relates to compounds of formula (I) and the use of these compounds as pharmaceuticals, e.g. in preventing or treating a CXCR2 receptor mediated condition or disease.

Abstract: Compounds of formula (I): are inhibitors of MARK, and hence useful for treatment of disorders involving 10 hyperphosphorylation of tau.

Abstract: The present invention relates to compounds of formula (I) wherein X, R1, R2, R3, R4 and R5 are as defined herein, which are useful for treating diseases which respond to CXCR2 receptor mediators. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Abstract: Compounds of formula (IA) and (IB) are inhibitors of MARK, and hence are suitable for treatment of Alzheimer's disease.

Abstract: Compounds of formula I in free or salt or solvate form, where T1, T2, X, Ra, Rb, R8 and R9 have the meanings as indicated in the specification, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pulmonary fibrosis, liver fibrosis, muscle diseases and systemic skeletal disorders. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Abstract: The invention provides a method of screening for compounds which inhibit the hyperphosphorylation of tau, and hence are suitable for treating AD and related conditions.

Abstract: A debug circuit for a multi-mode circuit driven by a clock signal, with an input for a clock signal, and a debug signal generator arranged to generate for each of a subset of the modes of the multi-mode circuit a corresponding debug signal based on a clock signal provided at the input. The frequency of debug signals is dependent on the frequency of a clock signal provided at the input, and each debug signal selects its respective mode for a length of time longer than that of each other mode of the multi-mode circuit, or each debug signal selects its respective mode for a length of time shorter than that of each other mode of the multi-mode circuit.

Abstract: The present invention relates to the reduction in errors in the phase of quadrature clock signals and provides a correction circuit for signals which are required to have as close to that precise phase relationship as possible. The arrangement is based upon a circuit which aims to bring signals which should be 180 degrees apart closer to a 50% duty cycle.

Abstract: Address Resolution Protocol (ARP) request mirroring can provide a mechanism for synchronizing link-layer adjacency information among network elements. This application can be useful, for example, for internet protocol (IP) routing network elements in a high-availability configuration.

Abstract: Selective passive address resolution protocol (ARP) learning can provide a passive mechanism to synchronize link layer adjacency information among network elements. Selective passive ARP learning can be implemented by a modification to the ARP requests processing of the standby node, with a filter list containing a set of match rules for target network addresses. The implementation, thus, can be a configurable filter that enables software modules to specify a set of internet protocol (IP) addresses that the ARP input engine should monitor.