Abstract: A system includes a near eye display (NED) that comprises an optical assembly with an electronic display, an imaging sensor configured to capture images of a user's hands, and an eye imaging sensor configured to capture images of an eye of the user. The system also includes a controller configured to determine eye tracking information using the captured images of the eye, the eye tracking information indicating a gaze orientation, wherein the gaze orientation terminates at first location. The controller determines that a pose of the user's hand indicates a pinch gesture based on the captured images of the user's hands. The controller also identifies an object in the local area that is at the first location, and updates the display instructions to cause the electronic display to display an indication of a selection of the object in an artificial reality environment.

Abstract: The present invention provides microparticles that induce the migration of multipotent stem cells to the anatomical site of the microparticles. Various release profiles are demonstrated that depend upon the relative concentration of alginate in the chemokine-loaded microparticle. Local administration and/or intraarticular injection of the microparticles are useful in conditions such as osteoarthritis. Targeted systemic delivery of the alginate chemokine microparticles to distant anatomical sites subjected to autoimmune disease symptomology can be performed by encapsulation within liposomes having targeting ligands. Consequently, upon the creation of the appropriate chemokine gradient, multipotent stem cells will migrate to the distant anatomical site where the liposomes are attached.

Abstract: A system includes a near eye display (NED) that is configured to display images in accordance with display instructions. The system also includes an imaging sensor configured to capture images. The system further includes a controller configured to identify the object in the captured images using one or more recognition patterns, and to determine a pose of the user's hand based on the captured images, with the determined pose indicating a touch gesture with the identified object. The controller also updates the display instructions to cause the electronic display to display a virtual menu in an artificial reality environment, with the virtual menu within a threshold distance of the position of the object in the artificial reality environment.

Abstract: The present invention provides microparticles that deliver in vivo predictable release profiles of at least one chemokine to create a biomimetic chemokine concentration gradient that induces the migration of multipotent stem cells to the anatomical site of the microparticles. Various release profiles are demonstrated that depend upon the relative concentration of alginate in the chemokine-loaded microparticle. Local administration and/or intraarticular injection of the microparticles are useful in conditions such as osteoarthritis. Targeted systemic delivery of the alginate chemokine microparticles to distant anatomical sites subjected to autoimmune disease symptomology can be performed by encapsulation within liposomes having targeting ligands. Consequently, upon the creation of the appropriate chemokine gradient, multipotent stem cells will migrate to the distant anatomical site where the liposomes are attached.

Abstract: Provided are a method of producing a cross-linked PVA-ECM composite, and a PVA-ECM composite produced by using the method.

Abstract: The present invention provides microparticles that deliver in vivo predictable release profiles of at least one chemokine to create a biomimetic chemokine concentration gradient that induces the migration of multipotent stem cells to the anatomical site of the microparticles. Various release profiles are demonstrated that depend upon the relative concentration of alginate in the chemokine-loaded microparticle. Local administration and/or intraarticular injection of the microparticles are useful in conditions such as osteoarthritis. Targeted systemic delivery of the alginate chemokine microparticles to distant anatomical sites subjected to autoimmune disease symptomology can be performed by encapsulation within liposomes having targeting ligands. Consequently, upon the creation of the appropriate chemokine gradient, multipotent stem cells will migrate to the distant anatomical site where the liposomes are attached.

Abstract: The present invention relates to a target-specific probe containing T7 bacteriophage with a targeting antibody, and a detection method or a detection kit for a biomarker using the target-specific probe. The biomarker can be detected by using the genetically-modified T7 bacteriophage expressing various heterogeneous proteins and peptides on its surface and antibody-antigen specific reaction which can make the probe targeted to a biomarker or bacteria; and a detectable labeling agent, for example a quantum dot.

Abstract: This invention relates to a target-specific probe containing a ferritin fusion protein and a targeting agent, a target-specific imaging probe containing a labeling agent coupled to the target-specific probe, and a detection method or detection kit of a biomarker using these probes.

Abstract: Devices, systems and methods using low frequency ultrasound to emulsify, disintegrate, cut and/or coagulate tissue in a narrow space such as the nasal passages and paranasal sinuses. The devices may comprise a low frequency generator, a functionally active handle, an ultrasound emitter, a concentrator, a waveguide and distal functional tips. The devices and methods are configured to safely and efficiently carry out surgical procedures within the nose and sinuses, among other soft tissues within the body.

Abstract: A method includes initiating a compression operation to compress data to be stored in a group of storage elements at a memory device that includes an error correction coding (ECC) engine. The method includes selecting one of a first mode of the ECC engine to generate a first number of parity bits and a second mode of the ECC engine to generate a second number of parity bits based on an extent of compression of the data. The method also includes encoding the compressed data to generate parity bits corresponding to the compressed data and storing the compressed data and the parity bits to the group of storage elements according to a page format that includes a data portion and a parity portion. The compressed data is stored in the data portion and at least some of the parity bits are stored in the parity portion.

Abstract: A method and apparatus for reducing power consumption during an operation in a non-volatile storage device is disclosed. A non-volatile storage device controller that is in communication with a non-volatile memory in the non-volatile storage device receives a characteristic corresponding to a time duration required for the non-volatile memory to complete an operation. The controller disables a circuit that indicates when an operation by the non-volatile memory is complete. The controller then initiates the operation in the non-volatile memory, and maintains the circuit in a disabled state for a first predetermined time that is a portion of the time duration. The controller enables the circuit upon expiration of the first predetermined time and prior to the completion of the operation. The controller receives an indication of the completion of the operation via the circuit.

Abstract: A method of modifying properties of intrinsic tissue of an organ is provided. The method includes providing an organ, where a first electrode is disposed proximal to the organ first end. The first electrode has a surface area and insulator. A second electrode is disposed opposite the first electrode, where the organ is disposed between the first electrode and the second electrode. The second electrode has surface area and surface insulator. An organ-shaping device is provided that is disposed on the organ between the electrodes, where the organ-shaping device deforms the organ middle section along at least one lateral direction between the electrodes. An electric current is provided between the first second electrodes, where a current density gradient is provided by the electrode surface areas and the deformed organ middle section, and the properties of the intrinsic muscle tissue are modified according to the current density gradient.

Abstract: A method and apparatus for reducing power consumption during an operation in a non-volatile storage device is disclosed. A non-volatile storage device controller that is in communication with a non-volatile memory in the non-volatile storage device receives a characteristic corresponding to a time duration required for the non-volatile memory to complete an operation. The controller disables a circuit that indicates when an operation by the non-volatile memory is complete. The controller then initiates the operation in the non-volatile memory, and maintains the circuit in a disabled state for a first predetermined time that is a portion of the time duration. The controller enables the circuit upon expiration of the first predetermined time and prior to the completion of the operation. The controller receives an indication of the completion of the operation via the circuit.

Abstract: A method includes initiating a compression operation to compress data to be stored in a group of storage elements at a memory device that includes an error correction coding (ECC) engine. The method includes selecting one of a first mode of the ECC engine to generate a first number of parity bits and a second mode of the ECC engine to generate a second number of parity bits based on an extent of compression of the data. The method also includes encoding the compressed data to generate parity bits corresponding to the compressed data and storing the compressed data and the parity bits to the group of storage elements according to a page format that includes a data portion and a parity portion. The compressed data is stored in the data portion and at least some of the parity bits are stored in the parity portion.

Abstract: A method of modifying properties of intrinsic tissue of an organ is provided. The method includes providing an organ, where a first electrode is disposed proximal to the organ first end. The first electrode has a surface area and insulator. A second electrode is disposed opposite the first electrode, where the organ is disposed between the first electrode and the second electrode. The second electrode has surface area and surface insulator. An organ-shaping device is provided that is disposed on the organ between the electrodes, where the organ-shaping device deforms the organ middle section along at least one lateral direction between the electrodes. An electric current is provided between the first second electrodes, where a current density gradient is provided by the electrode surface areas and the deformed organ middle section, and the properties of the intrinsic muscle tissue are modified according to the current density gradient.

Abstract: In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the treatment or prevention of a viral infection are provided. In another aspect of the invention, compounds useful in the treatment or prevention of HCV infection are provided.

Abstract: The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.

Abstract: The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.

Abstract: The illustrated input and output trays are pivotally attached to the hardcopy device and are movable between a processing position and a storage position.

Abstract: A printing-fluid container includes a reservoir having a leading surface with an outer perimeter. Redundant interface elements are recessed from the leading surface interior the outer perimeter.