Abstract: Compounds of general formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are as defined herein are useful for treating respiratory disease and other diseases and conditions modulated by TMEM16A.

Abstract: Compounds of general formula (I) and their tautomeric forms all enantiomers and isotopic variants and salts and solvates thereof: wherein represents a single or a double bond and R1, R2, X1, X2, X3, X4, X5, Y and Z are as defined herein; are useful for treating respiratory disease and other diseases and conditions modulated by TMEM16A.

Abstract: Compounds of general formula (1): wherein R1, R2, R3, R4, R5a, R* X1, X2, Z and Y are as defined herein are positive modulators of the N H calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.

Abstract: Compounds of general formula (I): wherein R1, R2, R3, R4, R5a, R5b X1, X2, Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.

Abstract: The invention provides a method of obtaining data cubes such that elimination of the irrelevant portion of the illumination reveals the low intensity intrinsic spectral components. The method obtains target and reference data cubes using a single camera and of a single field of view so that low-level intrinsic spectral components may be detected and enhanced under conditions of high illumination intensity without the use of filters. Two exposures in rapid succession of the same field of view at the same camera settings are taken, one exposure of the target is taken under coherent conditions where the field of view is in focus, and the second exposure is of the same field of view taken under non-coherent conditions where the target is defocused such that it has no discernible spatial features in the field of view.

Abstract: A method is provided to obtain a full range intrinsic spectral signature for spectroscopy and spectral imaging. The method eliminates the irrelevant spectral components and is used to normalize the spectral intensities across the full wavelength ranges obtained from different instrumentation. The method determines the intrinsic instrument noise levels and the noise level across the spectral range is averaged for each spectrum. By determining the percent of the integrated instrument noise relative to the integrated illumination energy for each instrument, the instrument noise can be normalized to one common value and the intensity values of the intrinsic sample spectra can be normalized proportionately and combined into a continuous intrinsic spectrum across the wavelength ranges of the contributing instruments. The methodology is also implemented in spectral imaging and spectral data cubes.

Abstract: The present invention is a method of removing the illumination and background spectral components thus isolating spectra from multi-spectral and hyper-spectral data cubes. The invention accomplishes this by first balancing a reference and sample data cubes for each spectra associated with each location, or pixel/voxel, in the spatial image. The set of residual spectra produced in the balancing step is used to obtain and correct a new set of reference spectra that is used to remove the illumination and background components in a sample data cube.

Abstract: The present invention is a method of removing the illumination and background spectral components thus isolating spectra from multi-spectral and hyper-spectral data cubes. The invention accomplishes this by first balancing a reference and sample data cubes for each spectra associated with each location, or pixel/voxel, in the spatial image. The set of residual spectra produced in the balancing step is used to obtain and correct a new set of reference spectra that is used to remove the illumination and background components in a sample data cube.

Abstract: The present invention is a method of obtaining and isolating sample spectra from a wide wavelength illumination source without the use of filters. The method obtains the combined sample and illumination spectra of a sample and removes the illumination spectrum from the combined spectrum. This is accomplished by obtaining both the combined sample/illumination spectrum and the illumination spectrum separately at the same time and under the same environmental and instrument conditions. The illumination spectrum is then subtracted, wavelength by wavelength from the combined sample/illumination spectrum, leaving the pure sample spectrum which may a single spectrum or combination of two or more spectra from different types and/or compounds in the sample.

Abstract: A recess is formed into a first side of a wafer such that a thinned center portion of the wafer is formed, and such that the central portion is surrounded by a thicker peripheral edge support portion. The second side of the wafer remains substantially entirely planar. After formation of the thinned wafer, vertical power devices are formed into the first side of the central portion of the wafer. Formation of the devices involves forming a plurality of diffusion regions into the first side of the thinned central portion. Metal electrodes are formed on the first and second sides, the peripheral portion is cut from the wafer, and the thin central portion is diced to form separate power devices. In one example, a first commercial entity manufactures the thinned wafers, and a second commercial entity obtains the thinned wafers and performs subsequent processing to form the vertical power devices.

Abstract: A recess is formed into a first side of a wafer such that a thinned center portion of the wafer is formed, and such that the central portion is surrounded by a thicker peripheral edge support portion. The second side of the wafer remains substantially entirely planar. After formation of the thinned wafer, vertical power devices are formed into the first side of the central portion of the wafer. Formation of the devices involves forming a plurality of diffusion regions into the first side of the thinned central portion. Metal electrodes are formed on the first and second sides, the peripheral portion is cut from the wafer, and the thin central portion is diced to form separate power devices. In one example, a first commercial entity manufactures the thinned wafers, and a second commercial entity obtains the thinned wafers and performs subsequent processing to form the vertical power devices.

Abstract: A power device includes a gate electrode, a source electrode, and a drain electrode provided within an active region of a semiconductor substrate of first conductivity type. A vertical diffusion region of second conductivity is provided at a periphery the active region. The vertical diffusion region extends continuously from a top surface of the substrate to a bottom surface of the substrate. The vertical diffusion region includes an upper portion having a first depth and a lower portion having a second depth that is substantially greater than the first depth.

Abstract: A power device includes a gate electrode, a source electrode, and a drain electrode provided within an active region of a semiconductor substrate of first conductivity type. A vertical diffusion region of second conductivity is provided at a periphery the active region. The vertical diffusion region extends continuously from a top surface of the substrate to a bottom surface of the substrate. The vertical diffusion region includes an upper portion having a first depth and a lower portion having a second depth that is substantially greater than the first depth.

Abstract: A power device includes a gate electrode, a source electrode, and a drain electrode provided within an active region of a semiconductor substrate of first conductivity type. A vertical diffusion region of second conductivity is provided at a periphery the active region. The vertical diffusion region extends continuously from a top surface of the substrate to a bottom surface of the substrate. The vertical diffusion region includes an upper portion having a first depth and a lower portion having a second depth that is substantially greater than the first depth.

Abstract: A vehicle seat has a mechanism supporting a table for articulation between a stowed position and an extended position. A surface of the table extends generally horizontally from an integral part of the seat, a cover overlies the table surface, and the cover is detachably secured to the table in a manner that will allow the table to be moved to the stowed position and back to the extended position without damaging the cover.

Abstract: A vehicle seat is disclosed having a mechanism supporting a table for articulation between a stowed position and an extended position. A surface of the table extends generally horizontally from an integral part of the seat, a cover overlies the table surface, and the cover is detachably secured to the table in a manner that will allow the table to be moved to the stowed position and back to the extended position without damaging the cover.

Abstract: A power device includes a gate electrode, a source electrode, and a drain electrode provided within an active region of a semiconductor substrate of first conductivity type. A vertical diffusion region of second conductivity is provided at a periphery the active region. The vertical diffusion region extends continuously from a top surface of the substrate to a bottom surface of the substrate. The vertical diffusion region includes an upper portion having a first depth and a lower portion having a second depth that is substantially greater than the first depth.

Abstract: A vehicle seat is disclosed which has a mechanism supporting a table for articulation between a stowed position and an extended position. A surface of the table extends generally horizontally from an integral part of the seat, a cover overlies the table surface, and the cover is detachably secured to the table in a manner that will allow the table to be moved to the stowed position and back to the extended position without damaging the cover.