Abstract: The invention relates to a UV stable transdermal therapeutic system (TTS) consisting of a back layer, at least one matrix containing an active substance and optionally, a withdrawal film and an UV-radiation absorber. An adhesive layer containing said UV-radiation absorber is arranged between the back layer and the matrix containing an active substance which is distant as much as possible from a surface, a separation layer is arranged between the adhesive layer containing said UV-radiation absorber and the matrix containing an active substance, which is as remote as possible from the surface which is impermeable to the active substance and UV-radiation absorber. The inventive transdermal therapeutic system exhibits a high stability and is devoid of inconveniences of existing TTS containing a light-sensitive substance.

Abstract: The invention relates to a UV stable transdermal therapeutic system (TTS) consisting of a back layer, at least one matrix containing an active substance and optionally, a withdrawal film and an UV-radiation absorber. An adhesive layer containing said UV-radiation absorber is arranged between the back layer and the matrix containing an active substance which is distant as much as possible from a surface, a separation layer is arranged between the adhesive layer containing said UV-radiation absorber and the matrix containing an active substance, which is as remote as possible from the surface which is impermeable to the active substance and UV-radiation absorber. The inventive transdermal therapeutic system exhibits a high stability and is devoid of inconveniences of existing TTS containing a light-sensitive substance.

Abstract: The invention relates to a UV stable transdermal therapeutic system (TTS) consisting of a back layer, at least one matrix containing an active substance and, optionally, a withdrawal film and an UV-radiation absorber. An adhesive layer containing said UV-radiation absorber is arranged between the back layer and the matrix containing an active substance which is distant as much as possible from a surface, a separation layer is arranged between the adhesive layer containing said UV-radiation absorber and the matrix containing an active substance, which is as remote as possible from the surface which is impermeable to the active substance and UV radiation absorber. The inventive transdermal therapeutic system exhibits a high stability and is devoid of inconveniences of existing TTS containing a light-sensitive substance.

Abstract: Described are methods for providing prolonged physiologically acceptable steady state serum testosterone levels in a patient deficient in endogenous testosterone levels, methods for male contraception and methods for treating a disease or symptom associated with deficient endogenous levels of testosterone in a man, by intramuscularly administering testosterone esters in a vehicle.

Abstract: The present invention relates to pharmaceutical compositions, formulated for injectable administration, which comprises a testosterone ester, in particularly testosterone undecanoate, in a vehicle comprising castor oil and a co-solvent. Upon injecting the compositions according to a particular administration scheme, reliable levels of testosterone in serum in the normal physiological range is achieved for a long period. This allows for the use of the compositions in hormone replacement therapy and male contraception without concomitant monitoring of testosterone levels in serum by a physician.

Abstract: The present invention relates to methods for continuous treatment of diseases, conditions and/or symptoms associated with deficient endogenous levels of estrogen in a woman already receiving a therapeutically effective dose of an estrogen. More particularly, the present invention provides a safe and efficient step-down regimen for women already receiving estrogen therapy and which are potentially overdosed.

Abstract: Described are methods for providing prolonged physiologically acceptable steady state serum testosterone levels in a patient deficient in endogenous testosterone levels, methods for male contraception and methods for treating a disease or symptom associated with deficient endogenous levels of testosterone in a man, by intramuscularly administering testosterone esters in a vehicle.

Abstract: The present invention relates to methods for treating diseases, conditions or symptoms associated with deficient endogenous levels of estrogen comprising administration of a higher first dose of an estrogen followed by administration of a lower second dose of an estrogen once therapy has been effectively established. The invention further relates to a combination treatment comprising administration of an estrogen and a progestin.

Abstract: The invention relates to a UV stable transdermal therapeutic system (TTS) consisting of a back layer, at least one matrix containing an active substance and, optionally, a withdrawal film and an UV-radiation absorber. An adhesive layer containing said UV-radiation absorber is arranged between the back layer and the matrix containing an active substance which is distant as much as possible from a surface, a separation layer is arranged between the adhesive layer containing said UV-radiation absorber and the matrix containing an active substance, which is as remote as possible from the surface which is impermeable to the active substance and UV radiation absorber. The inventive transdermal therapeutic system exhibits a high stability and is devoid of inconveniences of existing TTS containing a light-sensitive substance.

Abstract: The present invention relates to pharmaceutical compositions, formulated for injectable administration, which comprises a testosterone ester, in particularly testosterone undecanoate, in a vehicle comprising castor oil and a co-solvent. Upon injecting the compositions according to a particular administration scheme, reliable levels of testosterone in serum in the normal physiological range is achieved for a long period. This allows for the use of the compositions in hormone replacement therapy and male contraception without concomitant monitoring of testosterone levels in serum by a physician.

Abstract: The invention relates to a multi-stage method for producing gas-filled microcapsules. In one stage of the method, the substance that forms the coat is polymerized. The microcapsules are formed in a physically and/or temporally separate stage, by means of a structuring process. The polymerization is carried out with moderate stirring, while the microcapsules are structured in dispersing conditions.

Abstract: A wire harness handling and storage system particularly suitable for use in connection with automated harness making machines includes a harness unloading mechanism that unloads a completed wire harness from the harness-making machine and a storage cart that receives a plurality of completed wire harnesses in a plurality of storage racks maintained at different elevations on the storage cart. The handling and storage system is adaptable to handle both short wire harnesses about 6 inches in length) to longer wire harnesses (about 10 feet in length) without tangling or damage to connectors applied to the wires of the wire harnesses. For unloading and placing the longer wire harnesses, a gripping mechanism is provided that picks up the wire harnesses and places on the storage cart in a controlled movement. The unloading and gripping mechanisms are linked with a controller knows the length of the storage areas of the cart for proper, high-density loading thereof.

Abstract: A method for taping together a plurality of wires to create a plurality of individual multiple wire harnesses includes first providing a number of wires, each wire having an end connected to any one of a plurality of end connectors. Then feeding tape to a taping mechanism and applying the tape to the wires along a direction perpendicular to the axes of the wires to form a single bound multiple wire harness. Finally, the bound multiple wire harness is cut into a plurality of individual multiple wire harnesses, each one including an end connector. An apparatus includes a tape feed and application mechanism for applying the tape to the wires along a direction perpendicular to the wires axes; and a tape cutting mechanism to form the plurality of multiple wire harnesses.

Abstract: A machine for producing wire harnesses of the type having multiple connectors terminated to the wires of the harness, the connectors being arranged in serial order along the length of the wire harness and some of the connectors being of two-piece construction is disclosed. The machine includes a reciprocating carriage and a nest that retains a lead connector in place during termination and subsequent advancement of the harness wires. The carriage is received within a termination assembly which has different termination members for different connectors.

Abstract: A wire transferring assembly for a wire harness assembly machine has two adjoining termination stations. First connector elements are advanced in a reciprocating nest from a supply of connector elements into contact with wires extending from a positioning head and terminated thereto. After termination, to the wires, the connector elements are drawn away in the nest from the wire feed source and the wires are cut at their ends opposite the first connector elements. The cut wires are clamped onto a moveable clamping head and maintained in a preselected order while they are transferred to a second termination location, where a row of second connector elements are advanced into contact with the wire ends and terminated thereto.

Abstract: An apparatus for loading individual connectors into a wire-harness making machine includes a feed track which feeds a supply of connectors which have been separated from a connector supply chain. The lead connector is advanced into a feed channel whereupon a severing knife is advanced into the feed channel to separate the lead connector from an adjacent connector. The severing knife remains in place momentarily as a shuttle mechanism is actuated to move the severed lead connector along the feed channel, the severing knife blade forming a portion of the feed channel during the shuttling of the severed connector. Optical sensors may be mounted in proximity to the severing knife in order to verify the presence or absence of a connector prior to severing.

Abstract: An apparatus for taping wires of a wire harness includes first and second tape application heads interconnected together and disposed proximate to a wire guiding mechanism. Both of the first and second tape application heads have hollow inner cores which communicate with a source of negative air pressure to draw a vacuum in each tape application head which causes a strip of wire tape to adhere to the outer surfaces of the application heads. One of the application heads is brought into contact with a plurality of wires guided across the head, while the second application head rotates around a common axis shared by the two heads, whereby each of the first and second application heads generally oppose each other and apply the strip of tape to the wires.

Abstract: A wire-shifting apparatus particularly suited for use in assembling wire or cable harnesses includes a pedestal portion having a plurality of individual, elongated wire guide members thereon. The wire guide members have a channel-like cross-section and some of the wire guide members are fixed in the position upon the pedestal portion, while others of the wire guide members are mounted on the pedestal portion so as to pivot about a fixed point so that upon urging by an actuator, the movable wire guides shift laterally in unison. The shifted wire guides then convey wires between two opposing connector elements in a manner such that selected wires are terminated at locations in one connector element which are removed one location from the other connector element.

Abstract: A wire harness-making machine for producing wire harnesses of the type in which multiple wires extend between opposing first and second electrical connector elements. The machine includes a feeding assembly which separates successive first wire connectors and a transfer nest which shuttles the first array of connectors from a first connector advancement track to a first termination station. Multiple wires are fed to the first termination station where first free ends thereof are terminated to the first connector. Once terminated to the multiple wires, the first connector is shuttled back to the first connector advancement track. The first connector is then advanced along a feedpath and a set of second free ends of the wires are transferred to a second termination station while maintaining the order of the wires.

Abstract: A wire holding device is disclosed for holding a plurality of discrete electrical wires in a side-by-side relationship and to facilitate providing longitudinal strain relief for the wires. The device includes a housing, and a plurality of generally parallel retaining passages through the housing for axially receiving and substantially surrounding the wires to retain the wires in substantially all radial directions. A plurality of access windows extend through the housing transversely of the retaining passages to provide access to the wires in the passages by an appropriate bending tool. Each retaining passage has a cavity opposite each respective window and into which a portion of a respective wire can be bent laterally of its axis so that the bent portion of the wire provides longitudinal strain relief for the wire.