Abstract: A method and device are used for administering a humidified aerosol to a patient interface by providing and guiding a first gas flow having a humidified aerosol, a second gas flow having humidified respiratory gases, and a liquid flow of a thermally balancing liquid, thermally balancing the first and second gas flow by parallel guiding the first and second gas flow such that the first and second gas flow are guided in a manner that they are at least partially surrounded by the liquid flow of the thermally balancing liquid, mixing the first and second gas flow to obtain enriched respiratory gases having the humidified aerosol, and administering the enriched respiratory gases to the patient interface. The method and the device avoid the administration of dry or re-dried powdered aerosols and unwanted accumulation of and blockage by powdered material. The device is useful in respiratory support of preterm infants.

Abstract: A system for respiration-controlled application of aerosol in powder form during artificial respiration or assisted respiration of a patient including an interface contacting the patient's respiratory tract, a unit for generating a respiratory gas flow, at least one inspiration line through gas flow is conducted to the interface, an aerosol generator, at least one aerosol line through which the generated aerosol is conducted from the aerosol generator to the interface, and a respiration sensor that detects the patient's respiration signal. A valve in the at least one aerosol line is controlled based on the detected respiratory signal. An intermediate store for generated aerosol in powder form is arranged between the valve and the aerosol generator. The gas flow has a first pressure that is higher than or equal to ambient pressure and the aerosol has a second pressure that is higher than or equal to the first pressure.

Abstract: The invention relates to a humidifier configured to humidify an aerosol, the humidifier comprising a first water compartment (100) containing water used to humidify the aerosol; a second water compartment (300) containing water used to humidify the aerosol; an intermediate chamber (200) located between the first and the second water compartment (100, 300), the intermediate chamber (200) comprising an aerosol inlet (210) and an aerosol outlet (220) and providing first boundary surfaces of a passageway (230) through which the aerosol to be humidified passes; a first layer (10) permeable to water vapour and impermeable to liquid water, which is located between the first water compartment (100) and the intermediate chamber (200), wherein a section of the first layer provides a second boundary surface of the passageway; a second layer (20) permeable to water vapour and impermeable to liquid water, which is located between the second water compartment (300) and the intermediate chamber (200), wherein a section of t

Abstract: The invention relates to a device (10) for providing an aerosol from an aerosolizable material, the device comprising an aerosolization unit (300) through which pressure pulses of a carrier gas (60) are passed; a reservoir (100) comprising the aerosolizable material and which provides the aerosolizable material to the aerosolization unit (300) where the aerosolizable material is entrained by the carrier gas (60); a material providing valve (210) located between the reservoir (100) and the aerosolization unit (300) which opens in direction of the aerosolization unit (300) and which is opened and closed by a pressure difference between the reservoir (100) and the aerosolization unit (300) and which provides, in an open state, the aerosolizable material to the aerosolization unit (300).

Abstract: A method and device are used for administering a humidified aerosol to a patient interface by providing and guiding a first gas flow having a humidified aerosol, a second gas flow having humidified respiratory gases, and a liquid flow of a thermally balancing liquid, thermally balancing the first and second gas flow by parallel guiding the first and second gas flow such that the first and second gas flow are guided in a manner that they are at least partially surrounded by the liquid flow of the thermally balancing liquid, mixing the first and second gas flow to obtain enriched respiratory gases having the humidified aerosol, and administering the enriched respiratory gases to the patient interface. The method and the device avoid the administration of dry or re-dried powdered aerosols and unwanted accumulation of and blockage by powdered material. The device is useful in respiratory support of preterm infants.

Abstract: A system for respiration-controlled application of aerosol in powder form during artificial respiration or assisted respiration of a patient including an interface contacting the patient's respiratory tract, a unit for generating a respiratory gas flow, at least one inspiration line through gas flow is conducted to the interface, an aerosol generator, at least one aerosol line through which the generated aerosol is conducted from the aerosol generator to the interface, and a respiration sensor that detects the patient's respiration signal. A valve in the at least one aerosol line is controlled based on the detected respiratory signal. An intermediate store for generated aerosol in powder form is arranged between the valve and the aerosol generator. The gas flow has a first pressure that is higher than or equal to ambient pressure and the aerosol has a second pressure that is higher than or equal to the first pressure.

Abstract: A device and system for delivering an aerosol to a patient on ventilatory support comprise a contact component 10 to be positioned in contact with a respiratory organ. The contact component 10 comprises a lumen 18a, 20a, 24 through which breathing gas and an aerosol are delivered to lungs of a patient.

Abstract: A bioreactor for preferably three-dimensional cell culturing comprises a scaffold chamber, a first tube, a second tube and a first valve with a scaffold adapter, a tube adapter and a medium adapter. The first valve has a housing with a longitudinal female portion ending in an opening and a longitudinal actuator being arranged through the opening of the female portion of the housing such that the actuator is arranged partially inside the housing and partially outside the housing, wherein the actuator of the first valve is axially moveable relative to the housing of the first valve between a first position in which the first valve is in the operation position and a second position in which the first valve is in the medium change position. By providing the actuators in the first valve which is applied by axial movements, operation of the bioreactor can be comparably simple and safe.

Abstract: The invention relates to aerosolized and humidified particles comprising a therapeutically active substance which can be obtained by suspending dry inhalable particles in a carrier gas, adding water vapor and causing condensation of water on the particles. The invention further relates to methods to generate these particles, and apparatus useful to carry out such methods.

Abstract: The invention relates to a humidifier configured to humidify an aerosol, the humidifier comprising a first water compartment (100) containing water used to humidify the aerosol; a second water compartment (300) containing water used to humidify the aerosol; an intermediate chamber (200) located between the first and the second water compartment (100, 300), the intermediate chamber (200) comprising an aerosol inlet (210) and an aerosol outlet (220) and providing first boundary surfaces of a passageway (230) through which the aerosol to be humidified passes; a first layer (10) permeable to water vapour and impermeable to liquid water, which is located between the first water compartment (100) and the intermediate chamber (200), wherein a section of the first layer provides a second boundary surface of the passageway; a second layer (20) permeable to water vapour and impermeable to liquid water, which is located between the second water compartment (300) and the intermediate chamber (200), wherein a section of t

Abstract: The invention relates to a device (10) for providing an aerosol from an aerosolizable material, the device comprising an aerosolization unit (300) through which pressure pulses of a carrier gas (60) are passed; a reservoir (100) comprising the aerosolizable material and which provides the aerosolizable material to the aerosolization unit (300) where the aerosolizable material is entrained by the carrier gas (60); a material providing valve (210) located between the reservoir (100) and the aerosolization unit (300) which opens in direction of the aerosolization unit (300) and which is opened and closed by a pressure difference between the reservoir (100) and the aerosolization unit (300) and which provides, in an open state, the aerosolizable material to the aerosolization unit (300).

Abstract: The claimed subject matter relates to a device for dosing and aerosolization of aerosolizable material. The device includes a body with an aerosolization channel with a distal attachment for connecting a source of carrier gas. The carrier gas provides pressure pulses to the aerosolization channel. A proximal attachment allows the aerosolized material to move to a reservoir for receiving the aerosolizable material. The reservoir is connected to the body via the the aerosolization channel. At least part of the walls of the device are self-exciting membranes that can be put into oscillation by the pressure pulses.

Abstract: A bioreactor for preferably three-dimensional cell culturing comprises a scaffold chamber, a first tube, a second tube and a first valve with a scaffold adapter, a tube adapter and a medium adapter. The first valve has a housing with a longitudinal female portion ending in an opening and a longitudinal actuator being arranged through the opening of the female portion of the housing such that the actuator is arranged partially inside the housing and partially outside the housing, wherein the actuator of the first valve is axially moveable relative to the housing of the first valve between a first position in which the first valve is in the operation position and a second position in which the first valve is in the medium change position. By providing the actuators in the first valve which is applied by axial movements, operation of the bioreactor can be comparably simple and safe. In particular, such arrangement allows for a comparably easy identification of the position of the first valve, i.e., e.g.

Abstract: The invention relates to a device for dosing and aerosolization of aerosolizable material. The device comprises a body with an aerosolization channel with a distal attachment portion connectable to a source of carrier gas which provides pressure pulses to the aerosolization channel; a proximal attachment portion for outputting aerosolized material and a reservoir for receiving aerosolizable material. The reservoir comprises walls and is connected in a gas-tight manner to the body and in fluid connection with the aerosolization channel. At least part of the walls of the device are self-exciting membranes that can be put into oscillation by the pressure pulses.

Abstract: The claimed subject matter relates to a device for dosing and aerosolization of aerosolizable material. The device comprises: a body with an aerosolization channel with a distal attachment portion connectable to a source of carrier gas which provides pressure pulses to the aerosolization channel; a proximal attachment portion for outputting aerosolized material and a reservoir for receiving aerosolizable material. The reservoir comprises walls and is connected in a gas-tight manner to the body and in fluid connection with the aerosolization channel. At least part of the walls of the device are self-exciting membranes that can be put into oscillation by the pressure pulses.

Abstract: A device and system for delivering an aerosol to a patient on ventilatory support comprise a contact component 10 to be positioned in contact with a respiratory organ. The contact component 10 comprises a lumen 18a, 20a, 24 through which breathing gas and an aerosol are delivered to lungs of a patient.

Abstract: The invention relates to aerosolized and humidified particles comprising a therapeutically active substance which can be obtained by suspending dry inhalable particles in a carrier gas, adding water vapor and causing condensation of water on the particles. The invention further relates to methods to generate these particles, and apparatus useful to carry out such methods.

Abstract: The claimed subject matter relates to a device for dosing and aerosolization of aerosolizable material. The device comprises: a body with an aerosolization channel with a distal attachment portion connectable to a source of carrier gas which provides pressure pulses to the aerosolization channel; a proximal attachment portion for outputting aerosolized material and a reservoir for receiving aerosolizable material. The reservoir comprises walls and is connected in a gas-tight manner to the body and in fluid connection with the aerosolization channel. At least part of the walls of the device are self-exciting membranes that can be put into oscillation by the pressure pulses.

Abstract: A process and a device for preparing a dermis implant of a predefinable thickness provides for a section of skin (30) to be laid on a plate (20). Subcutaneous material is removed with a milling cutter (40) until the skin is of the desired thickness.

Abstract: The invention relates to a mixing device with a first chamber (1) for a first component, in particular a powder [a liquid], a second chamber (12) for a second component, in particular a liquid [powder], and a divider means (11, 13) separating the first and the second chamber. The second chamber is defined by an inner hollow cylinder (10) which is arranged so as to be moved in a piston-like fashion in an outer hollow body (2) defining the first chamber. According to the invention, the first chamber comprises an evacuation opening (5) which is adapted to be connected with a vacuum source. The invention further relates to a method for vacuum packaging the mixing device.