Abstract: The present invention provides amino substituted pyridinyl methanone compounds; pharmaceutical compositions comprising the compounds and methods of synthesis thereof. The compounds, which are cyclin dependent kinase (CDK) inhibitors, can be used to treat or ameliorate CDK mediated disorders. The invention thus also provides the therapeutic or prophylactic use of the compounds and/or pharmaceutical compositions to treat such disorders.

Abstract: The present invention is directed to novel hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives of the general formula wherein all variables are as defined herein, useful in the treatment of disorders and conditions mediated by the ORL-1 G-protein coupled receptor. More particularly, the compounds of the present invention are useful in the treatment of disorders and conditions such as anxiety, depression, panic, dementia, mania, bipolar disorder, substance abuse, neuropathic pain, acute pain, chronic pain, migraine, asthma, cough, psychosis, schizophrenia, epilepsy, hypertension, obesity, eating disorders, cravings, diabetes, cardiac arrhythmia, irritable bowel syndrome, Crohn's disease, urinary incontinence, adrenal disorders, attention deficit disorder (ADD), attention deficit hyperactivity disorder (ADHD), Alzheimer's disease, for improved cognition or memory and for mood stabilization.

Abstract: The present invention provides substituted triazole diamine derivatives as selective kinase or dual-kinase inhibitors and a method for treating or ameliorating a selective kinase or dual-kinase mediated disorder.

Abstract: This invention relates to a series of substitituted amino acids of Formula I 1

Abstract: The present invention is directed to novel hydroxy alkyl substituted 1,3,8-triazaspiro[4.

Abstract: This invention relates to a series of substituted amino acids of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention are small molecules which bind to the erythropoietin receptor and compete with the natural ligand for binding to this receptor.

Abstract: The present invention provides substituted triazole diamine derivatives as selective kinase or dual-kinase inhibitors and a method for treating or ameliorating a selective kinase or dual-kinase mediated disorder.

Abstract: The present invention provides pyrazine derivatives that inhibit tyrosine kinase activity. Certain pyrazine derivatives are selective inhibitors of vascular endothelial growth factor (VEGF) receptor tyrosine kinase. The present invention also provides pharmaceutical formulations containing the pyrazine derivatives and methods of use of these formulations as anti-tumor agents and to treat solid-tumor cancers, angiogenesis, diabetic retinopathy, rheumatoid arthritis, endometriosis and psoriasis.

Abstract: The present invention provides pyrazine derivatives that inhibit tyrosine kinase activity. Certain pyrazine derivatives are selective inhibitors of vascular endothelial growth factor (VEGF) receptor tyrosine kinase. The present invention also provides pharmaceutical formulations containing the pyrazine derivatives and methods of use of these formulations as anti-tumor agents and to treat solid-tumor cancers, angiogenesis, diabetic retinopathy, rheumatoid arthritis, endometriosis and psoriasis.

Abstract: This invention relates to a series of substitituted amino acids of Formula I 1

Abstract: This invention relates to a series of substituted amino acids of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention are small molecules which bind to the erythropoietin receptor and compete with the natural ligand for binding to this receptor.

Abstract: A low phase error antenna. The antenna is adapted for use with the Global Positioning System and includes a spiral antenna for receiving electromagnetic energy at a first standard frequency (L1) and a second standard frequency (L2). The spiral antenna has a spiral element with a circumference greater than approximately one and a half times the wavelength of electromagnetic energy at the lowest frequency (L2). The cavity of the antenna is unloaded and includes a balun adjusted for zero squint. The antenna element is either a logarithmic spiral or an archimedian spiral. In the illustrative embodiment, the spiral antenna includes a cavity having a depth which varies in accordance with the received electromagnetic energy. The cavity is approximately ¼ of a wavelength deep at the positions along spiral that receive electromagnetic energy.

Abstract: A quadrifilar helix antenna containing a hybrid junction power divider feed circuit and a plurality of radiating elements. The radiating elements are connected on one end to the hybrid junction power divider feed circuit and are free to radiate on the other end. In a particular embodiment, the antenna includes a microstrip hybrid junction power divider feed circuit deposited on the lower rectangular section of a dielectric substrate. The hybrid junction power divider feed circuit provides both a 0 to 180 degree phase shift and impedance matching. The antenna also includes four radiating microstrip elements deposited on the upper section of the dielectric substrate at a predetermined angle to form a helical pattern upon turning the planar antenna into a cylinder. The radiating elements are connected to the microstrip hybrid junction power divider feed circuit in pairs.

Abstract: Compounds of the general formula I: ##STR1## are disclosed as useful in the treatment or prevention of hypercholesterolemia, hyperlipoproteinemia and atherosclerosis. Novel intermediate compounds used to make the compound of formula I are also disclosed.

Abstract: An improved helix antenna including a single unitary antenna having plural radiating elements extending radially from a common junction. A microstrip balun is connected to the plural antenna elements at the common junction. In a particular embodiment, the antenna includes four radiating elements arranged in a helical pattern and mounted such that a longitudinal axis extending through the axial center of the antenna is coincident with a longitudinal axis of the microstrip balun. One or more of the radiating elements includes a semi-circular loop to create phase relationships necessary for a circularly polarized beam pattern. The microstrip balun includes a transmission line and a ground plane on opposite sides of a dielectric substrate. The transmission line and the ground plane are tapered for impedance matching between the input and the output thereof.

Abstract: Compounds of the general formula I: ##STR1## are disclosed as useful in the treatment or prevention of hypercholesterolemia, hyperlipoproteinemia and atherosclerosis. Novel intermediate compounds used to make the compound of formula I are also disclosed.

Abstract: Compounds of the general formula I: ##STR1## are disclosed as useful in the treatment or prevention of hypercholesterolemia, hyperlipoproteinemia and atherosclerosis. Novel intermediate compounds used to make the compound of formula I are also disclosed.

Abstract: Compounds of the general formula I: ##STR1## are disclosed as useful in the treatment or prevention of hypercholesterolemia, hyperlipoproteinemia and atherosclerosis. Novel intermediate compounds used to make the compound of formula I are also disclosed.