Patents by Inventor Peter J. Crisalli

Peter J. Crisalli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TAGGED MULTI-NUCLEOTIDES USEFUL FOR NUCLEIC ACID SEQUENCING
    Publication number: 20210292832
    Abstract: The present disclosure relates to tagged multi-nucleotide compounds, which comprise a single tag moiety covalently linked to a plurality of nucleoside-5?-oligophosphate moieties. As disclosed herein, these tagged multi-nucleotide compounds have improved characteristics as polymerase substrates and can be used in a range of nucleic acid detection and sequencing methods, including nanopore sequencing-by-synthesis.
    Type: Application
    Filed: February 22, 2021
    Publication date: September 23, 2021
    Applicant: Roche Sequencing Solutions, Inc.
    Inventors: Dmitriy Gremyachinskiy, Meng Taing, Aruna Ayer, Peter J. Crisalli
  • Tagged multi-nucleotides useful for nucleic acid sequencing
    Patent number: 10975432
    Abstract: The present disclosure relates to tagged multi-nucleotide compounds, which comprise a single tag moiety covalently linked to a plurality of nucleoside-5?-oligophosphate moieties. As disclosed herein, these tagged multi-nucleotide compounds have improved characteristics as polymerase substrates and can be used in a range of nucleic acid detection and sequencing methods, including nanopore sequencing-by-synthesis.
    Type: Grant
    Filed: March 18, 2020
    Date of Patent: April 13, 2021
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Dmitriy Gremyachinskiy, Meng Taing, Aruna Ayer, Peter J. Crisalli
  • TAGGED NUCLEOSIDE COMPOUNDS USEFUL FOR NANOPORE DETECTION
    Publication number: 20200385803
    Abstract: The disclosure relates to tagged nucleoside compounds comprising a nucleotide polyphosphate covalently attached to a tag, wherein the compound is a polymerase substrate and the polymer moiety is capable of entering a nanopore linked to the polymerase and thereby altering the flow of ions through the nanopore. The disclosure also provides methods for preparing the tagged nucleoside compounds and for their use as tags in nanopore-based nucleic acid detection and sequencing.
    Type: Application
    Filed: August 25, 2020
    Publication date: December 10, 2020
    Inventors: Frank Bergmann, Peter J. Crisalli, Sara Kelley, Omid Khakshoor, Hannes Kuchelmeister, Meng Taing
  • TAGGED MULTI-NUCLEOTIDES USEFUL FOR NUCLEIC ACID SEQUENCING
    Publication number: 20200263248
    Abstract: The present disclosure relates to tagged multi-nucleotide compounds, which comprise a single tag moiety covalently linked to a plurality of nucleoside-5?-oligophosphate moieties. As disclosed herein, these tagged multi-nucleotide compounds have improved characteristics as polymerase substrates and can be used in a range of nucleic acid detection and sequencing methods, including nanopore sequencing-by-synthesis.
    Type: Application
    Filed: March 18, 2020
    Publication date: August 20, 2020
    Applicant: Roche Sequencing Solutions, Inc.
    Inventors: Dmitriy Gremyachinskiy, Meng Taing, Aruna Ayer, Peter J. Crisalli
  • Tagged multi-nucleotides useful for nucleic acid sequencing
    Patent number: 10655174
    Abstract: The present disclosure relates to tagged multi-nucleotide compounds, which comprise a single tag moiety covalently linked to a plurality of nucleoside-5?-oligophosphate moieties. As disclosed herein, these tagged multi-nucleotide compounds have improved characteristics as polymerase substrates and can be used in a range of nucleic acid detection and sequencing methods, including nanopore sequencing-by-synthesis.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: May 19, 2020
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Dmitriy Gremyachinskiy, Meng Taing, Aruna Ayer, Peter J. Crisalli
  • TAGGED MULTI-NUCLEOTIDES USEFUL FOR NUCLEIC ACID SEQUENCING
    Publication number: 20190241952
    Abstract: The present disclosure relates to tagged multi-nucleotide compounds, which comprise a single tag moiety covalently linked to a plurality of nucleoside-5?-oligophosphate moieties. As disclosed herein, these tagged multi-nucleotide compounds have improved characteristics as polymerase substrates and can be used in a range of nucleic acid detection and sequencing methods, including nanopore sequencing-by-synthesis.
    Type: Application
    Filed: November 26, 2018
    Publication date: August 8, 2019
    Inventors: Aruna Ayer, Peter J. Crisalli, Dmitriy Gremyachinskiy, Meng Taing
  • TAGGED NUCLEOTIDES USEFUL FOR NANOPORE DETECTION
    Publication number: 20180057870
    Abstract: The present disclosure relates to compounds comprising a negatively-charged polymer moiety which is capable of entering a nanopore and upon entering a nanopore in the presence of positive ions results in an increased flow of the positive ions through the nanopore. The present disclosure provides methods of preparing the compounds and for their use as nanopore-detectable tags, in particular, for nanopore-based nucleic acid detection and sequencing.
    Type: Application
    Filed: August 23, 2017
    Publication date: March 1, 2018
    Inventors: Dmitriy Gremyachinskiy, Peter J. Crisalli, Andrew Trans, Ashwini Bhat