Abstract: Computerized systems and methods are provided for automatically generating an application overflow tool that is dynamically updated and arranged to provide improved access to popular or recently used applications. These systems and methods improve existing technologies by generating an overflow panel different from a task bar, such that the overflow panel provides access to most recently used applications that are not on the task bar. As such, ease of access to applications is improved to increase user efficiency. These systems also improve the way computers operate by leveraging existing GUI layouts to reduce computing resource consumption, such as memory, network latency, I/O, and the like, that would otherwise be required improve access to applications.

Abstract: Methods of treating cancer using antisense oligonucleotides directed against DNA double-strand break repair proteins such as BRCA2 or RAD51 are provided. The antisense oligonucleotides can he used alone, in tandem or in combination with other cancer therapies, in particular with therapies that lead to DNA damage, inhibition of DNA repair or inhibition of DNA synthesis, such as radiation, platinum drugs, alkylating agents, PARP inhibitors, or inhibitors of thymidylate synthase.

Abstract: Methods of treating cancer using antisense oligonucleotides directed against DNA double-strand break repair proteins such as BRCA2 or RAD51 are provided. The antisense oligonucleotides can be used alone, in tandem or in combination with other cancer therapies, in particular with therapies that lead to DNA damage, inhibition of DNA repair or inhibition of DNA synthesis, such as radiation, platinum drugs, alkylating agents, PARP inhibitors, or inhibitors of thymidylate synthase.

Abstract: Methods of treating cancer using antisense oligonucleotides directed against DNA double-strand break repair proteins such as BRCA2 or RAD51 are provided. The antisense oligonucleotides can be used alone, in tandem or in combination with other cancer therapies, in particular with therapies that lead to DNA damage, inhibition of DNA repair or inhibition of DNA synthesis, such as radiation, platinum drugs, alkylating agents, PARP inhibitors, or inhibitors of thymidylate synthase.

Abstract: A pin has a pilot point of uniform width throughout 360.degree. and a body containing a cross section of arcuate polygonal lobular configuration, also of uniform width but wider than the point. The pin may be driven into a circular hole in a member such that the lobes of the pin are elastically deformed in compression to enhance the grip between the pin and the member and with there being regions of stress relief on the member intermediate the lobes. The hole in the member may also be reshaped into a lobular form. The uniform body width approximates the minimum diameter of the hole in the member. Furthermore, the pin is of a range of lobulation sufficient to span a wide range of hole diameter tolerances.