Abstract: A puncture guard for a needle administration set having a needle assembly with a pair of flexible transverse wings includes a cylindrical sleeve which is outwardly flared at one end. One or more transverse openings are provided through the sleeve adjacent the opposite end. The administration set tubing is threaded axially through the sleeve with the flared end facing the needle assembly. Upon removal of the needle from the patient, the sleeve is grasped and the tubing is pulled so that the needle assembly wings engage the flared end of the sleeve. Further pulling of the tubing causes the wings to bend as the needle assembly is pulled into the sleeve. Rotation of the sleeve or tubing relative to each other when the wings are registered with the transverse opening causes the wings to spring outwardly through the transverse opening, locking the needle assembly within the sleeve with the tip of the needle safely confined.