Abstract: This disclosure relates to a method to identify xenobiotics that can debilitate a target organism. In particular, the present disclosure provides methods of heterologously expressing a xenobiotic metabolizing enzyme from the target organism in yeast, libraries of yeast strains heterologously expressing a different xenobiotic metabolizing enzyme and methods of screening libraries with xenobiotics to identify a xenobiotic that debilitates a target organism. The disclosure further relates to a method of treating or preventing a nematode infection comprising administering, to a subject in need thereof, an effective amount of a compound of Formula I, or a solvate thereof, as well as certain novel compounds of Formula I, or a solvate thereof.

Abstract: A table and a gas-driven cutting apparatus are provided. The table supports a workpiece in a manner suitable for cutting of the workpiece by the gas-driven cutting apparatus. The table includes an open table top having a plurality of openings for receiving the forced hot gases and a plurality of distributed horizontally arranged contact points for supporting the workpiece. The openings are distributed throughout the table top independently of the cutting paths of the gas-driven cutting apparatus. The table further includes a ventilated stationary negative pressure, situated below the table top and coupled to each of the openings. The table may include a plurality of vertically arranged slats having longitudinal axes extending across the open table top. A plurality of horizontally extending members (e.g., having an inverted V-shape) may be placed between each pair of slats that extend across the open table top.

Abstract: A table and a gas-driven cutting apparatus are provided. The table supports a workpiece in a manner suitable for cutting of the workpiece by the gas-driven cutting apparatus. The table includes an open table top having a plurality of openings for receiving the forced hot gases and a plurality of distributed horizontally arranged contact points for supporting the workpiece. The openings are distributed throughout the table top independently of the cutting paths of the gas-driven cutting apparatus. The table further includes a ventilated stationary negative pressure, situated below the table top and coupled to each of the openings. The table may include a plurality of vertically arranged slats having longitudinal axes extending across the open table top. A plurality of horizontally extending members (e.g., having an inverted V-shape) may be placed between each pair of slats that extend across the open table top.