Abstract: The invention provides a compound having the structure: wherein R1 and R2 are each independently H, halogen, —NO2, —CN, —NHR14, —NR14R15, —SR14, —SO2R14, —OR14, —CO2R14, —CF3, -alkyl-NR14R15, -alkyl-OR14, C1-10 alkyl, C2-10 alkenyl, or C2-10 alkynyl; or wherein R1 and R2 together formed into a cycloalkyl or cycloheteroalkyl; wherein R3 and R7 are each independently H, halogen, —NO2, —CN, —NHR14, —NR14R15, —SR14, —SO2R14, —OR14, —CO2R14, —CF3, -alkyl-NR14R15, C1-10 alkyl, C2-10 alkenyl or C2-10 alkynyl; wherein R4 and R6 are each independently H, —NO2, —SR14, —SO2R14, —OR14, —CO2R14, -alkyl-NR14R15, -alkyl-OR14, C2-10 alkenyl or C2-10 alkynyl; wherein R5 is —NO2, —NHR14, —NR14R15, —SR14, —SO2R14, —(C?O)—NH—R14, —CO2R14, -alkyl-NR14R15, -alkyl- OR14, C2-10 alkenyl, C2-10 alkynyl, —(C0-10 alkyl)-heterocyclyl, wherein R8, R9, R10, and R11 are each independently N or CH; wherein R12 is C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, aryl, heteroaryl, cycloalkyl, cycloheteroalky, or heterocyclyl; wherein

Abstract: This invention provides a composition comprising the compound having the structure: ethyl 2-[19F]F-4-nitrobenzoate, and at least one acceptable carrier. This invention also provides a method of detecting the presence of or location of bacteria cells in a subject which comprises determining if an amount of the compound or determining where an amount of the compound having the structure: is present in the subject at a period of time after administration of the compound or salt thereof to the subject, thereby detecting the presence of or location of the bacteria cells based on the amount of the compound determined to be present in the subject or detecting the location of the bacteria cells based on the location of the compound determined to be present in the subject.

Abstract: This application relates to methods and apparatus for controlling slew-rate of components for outputting an analogue output signal. Described is a signal processing circuit having a forward signal path for receiving an input signal and outputting an analogue output signal. The signal processing circuit has a first component located in said forward signal path for outputting the analogue output signal. A predictor is configured to predict a required slew-rate for the first component based on the input signal and a controller is configured to controllably vary an output slew-rate limit of the first component based on the prediction of required slew-rate.

Abstract: Provided herein are compounds of Formula (I) and pharmaceutically acceptable salts or tautomers thereof which may inhibit adenylate-forming enzymes. Also provided are pharmaceutical compositions, kits, uses, and methods involving the inventive compounds for the treatment and/or prevention of an infectious disease (e.g., bacterial infection (e.g., tuberculosis, methicillin-resistant Staphylococcus aureus)).

Abstract: Provided herein are compounds of Formula (I) and pharmaceuticals acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, and prodrugs thereof. Also provided are pharmaceutical compositions, kits, and methods involving the inventive compounds for the treatment of an infectious disease (e.g., bacterial infection (e.g., tuberculosis, methicillin-resistant Staphylococcus aureus).

Abstract: The present invention is directed to compounds having the formula: In the formula, A2 represents N or C—X1a—R1 and A4 represents N or C—X2b—R2, provided that A2 and A4 are not both N. R1 and R2 independently represent H or a hydrocarbon group, provided that R1 and R2 are not both H. The hydrocarbon groups of R1 and R2 are preferably alkyl or alkenyl groups. More preferably, the hydrocarbon groups are alkyl groups. A1, A3, A6, and A8 independently represent CH or N. A5 and A9 independently represent CR3 or N, wherein R3 independently represents H, methyl, ethyl, or halo. A7 represents CR4 or N, wherein R4 represents H, methyl, ethyl, halo, nitro, hydroxy, amino, amido, or a methyl or ethyl group substituted independently with halo, nitro, hydroxy, amino, or amido. Not more than three of A5, A6, A7, A8, and A9 are N.