Patents by Inventor Peter Jacobus Caspers

Peter Jacobus Caspers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11357405
    Abstract: An optical probe, instrument, and method for measuring a tissue sample. The optical probe comprises a needle having a needle tip formed to penetrate a tissue surface and an optical waveguide arranged to transmit light through the needle; and a probe housing for holding the needle and comprising at least one of an actuator or a sensor configured to receive or generate a depth signal to determine a depth position of the needle tip relative to the tissue surface.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: June 14, 2022
    Assignee: Erasmus University Medical Center Rotterdam
    Inventors: Gerwin Jan Puppels, Tom Christian Bakker Schut, Senada Koljenovic, Peter Jacobus Caspers
  • Publication number: 20200315459
    Abstract: An optical probe, instrument, and method for measuring a tissue sample. The optical probe comprises a needle having a needle tip formed to penetrate a tissue surface and an optical waveguide arranged to transmit light through the needle; and a probe housing for holding the needle and comprising at least one of an actuator or a sensor configured to receive or generate a depth signal to determine a depth position of the needle tip relative to the tissue surface.
    Type: Application
    Filed: December 21, 2015
    Publication date: October 8, 2020
    Applicant: Erasmus University Medical Center Rotterdam
    Inventors: Gerwin Jan PUPPELS, Tom Christian BAKKER SCHUT, Senada KOLJENOVIC, Peter Jacobus CASPERS
  • Patent number: 10531818
    Abstract: Method and instrument for analysing a tissue sample. Localized concentrations of an analyte are measured at a plurality of spaced apart locations around a controlled depth. Spatial variance of the analyte is calculated based on the measured analyte concentrations. The procedure is repeated while varying the controlled depth to obtain the spatial variance as a function of depth. Tissue at a particular depth may be evaluated as tumour tissue when the spatial variance is below the threshold. For example, a section distance is calculated between the tissue surface and a depth where the measured spatial variance crosses a predetermined threshold variance. Feedback can be provided based on a comparison between a calculated section distance and a pre-set minimum section margin.
    Type: Grant
    Filed: January 18, 2016
    Date of Patent: January 14, 2020
    Assignee: ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM
    Inventors: Gerwin Jan Puppels, Elisa Maria Barroso, Tom Christian Bakker Schut, Roeland W. H. Smits, Peter Jacobus Caspers, Senada Koljenovic
  • Publication number: 20180317818
    Abstract: Method and instrument for analysing a tissue sample. Localized concentrations of an analyte are measured at a plurality of spaced apart locations around a controlled depth. Spatial variance of the analyte is calculated based on the measured analyte concentrations. The procedure is repeated while varying the controlled depth to obtain the spatial variance as a function of depth. Tissue at a particular depth may be evaluated as tumour tissue when the spatial variance is below the threshold. For example, a section distance is calculated between the tissue surface and a depth where the measured spatial variance crosses a predetermined threshold variance. Feedback can be provided based on a comparison between a calculated section distance and a pre-set minimum section margin.
    Type: Application
    Filed: January 18, 2016
    Publication date: November 8, 2018
    Inventors: Gerwin Jan Puppels, Elisa Maria Barroso, Tom Christian Bakker Schut, Roeland W.H. Smits, Peter Jacobus Caspers, Senada Koljenovic
  • Publication number: 20170319070
    Abstract: The invention is directed to a method for non-invasive determination of the potential presence of one or more loss-of-function mutation(s) in the gene encoding for filaggrin. The method of the invention comprises (i) obtaining a vibrational spectrum from the stratum corneum of the individual; (ii) determining the local natural moisturising factor content from the vibrational spectrum; (iii) optionally repeating steps (i) and (ii); and (iv) comparing the local natural moisturising factor content of the individual to a reference value, wherein said stratum corneum is stratum corneum of a location of the body of said individual at which said one or more loss-of-function mutation(s) in the gene encoding for filaggrin has a stronger influence on the natural moisturising factor concentration than other factors influencing the natural moisturising factor concentration.
    Type: Application
    Filed: July 27, 2017
    Publication date: November 9, 2017
    Inventors: Peter Jacobus Caspers, Hok Bing Thio, Gerwin Jan Puppels, Patrick M. J. H. Kemperman, Hendrik Arent Martino Neumann
  • Patent number: 8368884
    Abstract: A spectroscopic apparatus for determining a concentration and/or spatial gradient of an analyte of a bodily fluid that provides determination of a position of a capillary vessel within a biological sample in order to focus spectroscopic excitation radiation to a volume that is in close proximity to the capillary vessel but does not overlap with the capillary vessel. The provided apparatus exploits the permeability of the vessel wall with respect to an analyte that is subject to analyte concentration determination. By means of biological transport processes, the concentration of an analyte of a bodily fluid located in the capillary vessel influences the concentration in the surrounding of the capillary vessel. Spectroscopic analysis of a volume outside the capillary vessel can therefore serve for a precise and reliable analyte concentration determination inside the capillary vessel.
    Type: Grant
    Filed: April 19, 2006
    Date of Patent: February 5, 2013
    Assignee: Koninklijke Philips Electronics N.V.
    Inventors: Gerhardus Wilhelmus Lucassen, Rufus Driessen, Kristiane Anne Schmidt, Gerwin Jan Puppels, Peter Jacobus Caspers
  • Publication number: 20120116232
    Abstract: The present invention relates to a method of using Raman spectra to identify unknown mutations in a gene, more specifically the filaggrin gene. Specifically, the present invention relates to a method to determine if a person has a homozygous or compound heterozygous mutation in the filaggrin-gene comprising measurement of the presence of tyrosine in the skin. Preferably said measurements are performed by Rama spectrography and on the tsiie of the skin, most preferably on the palm of the hand. Further, when these measurements are taken together with measurements of the NMF content of the skin it, the present invention relates to a method of classifying atopic dermatitis.
    Type: Application
    Filed: September 30, 2011
    Publication date: May 10, 2012
    Applicant: River Diagnotics B.V.
    Inventors: Peter Jacobus Caspers, Grainne O'Regan, Johanna de Sterke, Gerwin Jan Puppels
  • Publication number: 20100322860
    Abstract: The invention is directed to a method for non-invasive determination of the potential presence of one or more loss-of-function mutation(s) in the gene encoding for filaggrin. The method of the invention comprises (i) obtaining a vibrational spectrum from the stratum corneum of the individual; (ii) determining the local natural moisturising factor content from the vibrational spectrum; (iii) optionally repeating steps (i) and (ii); and (iv) comparing the local natural moisturising factor content of the individual to a reference value, wherein said stratum corneum is stratum corneum of a location of the body of said individual at which said one or more loss-of-function mutation(s) in the gene encoding for filaggrin has a stronger influence on the natural moisturising factor concentration than other factors influencing the natural moisturising factor concentration.
    Type: Application
    Filed: June 25, 2008
    Publication date: December 23, 2010
    Inventors: Peter Jacobus Caspers, Hok Bing Thio, Gerwin Jan Puppels, Patrick M.J.H. Kemperman, Hendrik Arent Martino Neumann
  • Patent number: 7656522
    Abstract: A Raman spectrum is measured inside animal tissue, such us human skin tissue, at a selected depth from a surface the tissue. A pH value is computed using a function that assigns a pH value as a function of the measured Raman spectrum. The computation may involve computing a number representing a ratio of concentrations of a protonated and a deprotonated version of a chemical substance from the Raman spectrum and generating pH information on the basis of said number. The chemical substance is for example a form of Urocanic acid (UCA). UV exposure is measured from the weight of the spectrum of cis-UCA.
    Type: Grant
    Filed: February 28, 2002
    Date of Patent: February 2, 2010
    Assignee: River Diagnostics B.V.
    Inventors: Gerwin Jan Puppels, Peter Jacobus Caspers, Gerhardus Wilhelmus Lucassen
  • Patent number: 6609015
    Abstract: An analysis apparatus including a spectroscopic analysis apparatus comprises an excitation system and a monitoring system. The excitation system emits an excitation beam to excite a target region during an excitation period. The monitoring system emits a monitoring beam to image the target region during a monitoring period. The excitation period and the monitoring period substantially overlap. Hence the target region is imaged together with the excitation, and an image is formed displaying both the target region and the excitation area. On the basis of this image, the excitation beam can be very accurately aimed at the target region.
    Type: Grant
    Filed: July 24, 2001
    Date of Patent: August 19, 2003
    Assignee: Koninklijke Philips Electronics N.V.
    Inventors: Gerhardus Wilhelmus Lucassen, Gerwin Jan Puppels, Peter Jacobus Caspers, Marjolein Van Der Voort, Egbert Lenderink, Martinus Bernardus Van Der Mark, Robert Frans Maria Hendriks, Julius Simon Cohen
  • Publication number: 20020133065
    Abstract: An analysis apparatus including a spectroscopic analysis apparatus comprises an excitation system and a monitoring system. The excitation system emits an excitation beam to excite a target region during an excitation period. The monitoring system emits a monitoring beam to image the target region during a monitoring period. The excitation period and the monitoring period substantially overlap. Hence the target region is imaged together with the excitation, and an image is formed displaying both the target region and the excitation area. On the basis of this image, the excitation beam can be very accurately aimed at the target region.
    Type: Application
    Filed: July 24, 2001
    Publication date: September 19, 2002
    Inventors: Gerhardus Wilhelmus Lucassen, Gerwin Jan Puppels, Peter Jacobus Caspers, Marjolein Van Der Voort, Egbert Lenderink, Martinus Bernardus Van Der Mark, Robert Frans Maria Hendriks, Julius Simon Cohen