Abstract: The present invention provides a method for analyzing simultaneously multiple human antigen-specific cell populations of a sample, the sample comprising B cells and antigen-specific cells, the method comprising a) separation of B cells from said sample, b) dividing the B cells into n sub-samples, c) differentially labeling the B cells of said sub-samples, wherein at least n-1sub-samples are labeled, d) pulsing of the B cells of each sub-sample with single or multiple peptides, e) pooling of the labeled and peptide-pulsed B cells with cells of said sample comprising said antigen-specific cells, f) co-cultivation of the cells of step e), g) flow cytometry analysis of the B cells with regard to their cell number and CD83 expression, thereby determining the potency of said antigen-specific cells in said sample.

Abstract: The present invention provides a method for analyzing simultaneously multiple human antigen-specific cell populations of a sample, the sample comprising B cells and antigen-specific cells, the method comprising a) separation of B cells from said sample, b) dividing the B cells into n sub-samples, c) differentially labeling the B cells of said sub-samples, wherein at least n-1sub-samples are labeled, d) pulsing of the B cells of each sub-sample with single or multiple peptides, e) pooling of the labeled and peptide-pulsed B cells with cells of said sample comprising said antigen-specific cells, f) co-cultivation of the cells of step e), g) flow cytometry analysis of the B cells with regard to their cell number and CD83 expression, thereby determining the potency of said antigen-specific cells in said sample.

Abstract: The invention relates to a chromatographic process for substance separation in the context of the preparation of chemicals such as, for example, chiral pharmaceuticals, isomers or biomolecules on the small-scale and production scale, based on Simulated Moving Bed (SMB=countercurrent chromatography) technology.

Abstract: To produce at least two bonded-together layers (11, 13; 11?, 13), it is proposed that the material of at least one of the layers (13) is melted and subsequently, by spray compacting with a spray cone (10, 10?), is applied to the other layer, which is moved in relation to the spray cone (10, 10?), in such a way that the material composite is thereby produced.

Abstract: To produce at least two bonded-together layers (11, 13; 11?, 13), it is proposed that the material of at least one of the layers (13) is melted and subsequently, by spray compacting with a spray cone (10, 10?), is applied to the other layer, which is moved in relation to the spray cone (10, 10?), in such a way that the material composite is thereby produced.

Abstract: The invention relates to a chromatographic process for substance separation in the context of the preparation of chemicals such as, for example, chiral pharmaceuticals, isomers or biomolecules on the small-scale and production scale, based on Simulated Moving Bed (SMB=countercurrent chromatography) technology.

Abstract: The invention relates to a chromatographic process for substance separation in the context of the preparation of chemicals such as, for example, chiral pharmaceuticals, isomers or biomolecules on the small-scale and production scale, based on Simulated Moving Bed (SMB=countercurrent chromatography) technology.

Abstract: Static mixer module, consisting of a disc which is provided with a multiplicity of orifices (6) and is structured on its front side and on its rear side by means of channels (4, 5), and in which the orifices (6) are made in the flanks (8) of the inlet channels (4) and open into the flanks (9) of the mixing channels (5). Furthermore, a mixer arrangement is described, which consists of at least two static mixer elements arranged one behind the other, at least one mixer element being a disc-shaped static mixer module. The mixer module and the mixer arrangement are used in pipelines and housings through which a flow passes.

Abstract: The invention relates to a chromatographic process for substance separation in the context of the preparation of chemicals such as, for example, chiral pharmaceuticals, isomers or biomolecules on the small-scale and production scale, based on Simulated Moving Bed (SMB=countercurrent chromatography) technology.

Abstract: A runner for a suspended ceiling grid is roll-formed from a single strip of sheet metal so as to have a generally symmetrical appearance about a vertical center line, with a double vertical web and a double-thickness flange for supporting ceiling tiles.

Abstract: A combination static mixer and heat exchanger having heat exchanger tubes (1) which are provided over their circumference with fins (2a, 2b) which have a static mixing effect.

Abstract: A suspended ceiling grid beam is provided that has an increased beam height to provide enhanced resistance to downward deflection. The beam has a cross-section generally in the form of an inverted T, with a central web, a pair of panel support flanges extending from one edge of the web, and a reinforcing bulb extending from the other edge of the web. The reinforcing bulb has a generally planar, fin-like structure extending therefrom opposite to and generally co-planar with the central web.

Abstract: A lift truck (6) for the transport of a battery block (1) of an industrial truck, such as a fork-lift truck. The lift truck (6) includes at least one electrical unit. The electrical unit can be connected with the battery block (1) to be transported for supplying electrical energy to the lift truck (6). The lift truck (6) may not have its own battery. The electrical unit can be an electrical traction drive motor.

Abstract: Modular device and method for carrying out experiments in parallel on process substances to develop technical methods, comprising at least a multiplicity of individual reactors which are controllable independently of one another said reactors being comprised of pressure-tight chambers having separable sample vessels, and optionally, stirring devices, heating instruments, cooling instruments, or both, a monitoring unit for monitoring or controlling at least the pressure and the temperature in the individual reactors, pressure-tight lids having independent feed lines and optionally independent discharge lines for individual process substances; a plurality of the lids being simultaneously sealable upon the rectors by a common sealing means (11).

Abstract: A grid system is provided that is particularly suited for the suspended ceiling system that varies in the vertical plane. An elongated carrier tube is provided the spans substantially the width of the grid system that has a slot therein adapted to receive the strengthening bulb of a main runner. A clip is provided that seats on the carrier tube that has opposed faces for capturing the bulb of the runner, so as to secure the runner to the tube carrier.

Abstract: A perimeter clip is made of a single piece of sheet metal and includes first and second legs that are bent at approximately 90 degrees with respect to each other. The first leg is for engaging the vertical leg of a wall angle. The second leg is adapted to receive the head or bulb of the runner. The first leg includes an upper portion and a lower portion. The upper portion of the first leg forms a back plate that is displaced from the plane of the lower portion, with a generally horizontal ledge connecting the upper portion to the lower portion. The first leg has a tongue or tab that is displaced from the plane of the remainder of the lower portion so that, when in place, the vertical leg of the wall angle is held between the tongue and the remainder of the lower portion. The upper portion of the second leg comprises an inverted, generally U-shaped member, the open end of which forms a trough that supports the lower surface of the bulb of the runner.

Abstract: A turbulence generator useful for mixing or as a heat exchanger, comprising a housing having an interior surface defined by an interior wall or walls, and an exterior surface, with at least two turbulence elements, each having at least one non-structured section (3) and at least one structured section (4), comprised of a plurality of alternating ribs (8) and gaps (9), removably inserted therein.

Abstract: This invention relates to an apparatus and a process for rapidly and accurately dispensing fluids, in which at least one component is dispensed into the reaction vessel in two or three stages. In this process, the amount of fluid dispensed in the second and third stages is determined on the basis of the mass flow rate calculated in the preceding sub-step.

Abstract: The invention describes a device for determining the gas content of a liquid. The device has at least a housing, a measuring chamber base with a cavity and a measuring chamber cover inside the housing. The measuring chamber base and the measuring chamber cover are each movable by a respective piston independently of one another along the longitudinal axis of the housing. The measuring chamber base and the measuring chamber cover form a measuring chamber in the housing. The measuring chamber base or the measuring chamber cover is connected to a pressure sensor and the housing has a liquid inlet and a liquid outlet.

Abstract: A modular, actuated valve controlled by means of pressure fluids comprising a head plate mounted on a housing plate mounted on a base plate, held together by screws, having a piston with attached valve spindle and a pressure relief space provided between the flow passage 28, 29 and the piston.