Abstract: The present invention provides a method for analyzing simultaneously multiple human antigen-specific cell populations of a sample, the sample comprising B cells and antigen-specific cells, the method comprising a) separation of B cells from said sample, b) dividing the B cells into n sub-samples, c) differentially labeling the B cells of said sub-samples, wherein at least n-1sub-samples are labeled, d) pulsing of the B cells of each sub-sample with single or multiple peptides, e) pooling of the labeled and peptide-pulsed B cells with cells of said sample comprising said antigen-specific cells, f) co-cultivation of the cells of step e), g) flow cytometry analysis of the B cells with regard to their cell number and CD83 expression, thereby determining the potency of said antigen-specific cells in said sample.

Abstract: The present invention provides a method for analyzing simultaneously multiple human antigen-specific cell populations of a sample, the sample comprising B cells and antigen-specific cells, the method comprising a) separation of B cells from said sample, b) dividing the B cells into n sub-samples, c) differentially labeling the B cells of said sub-samples, wherein at least n-1sub-samples are labeled, d) pulsing of the B cells of each sub-sample with single or multiple peptides, e) pooling of the labeled and peptide-pulsed B cells with cells of said sample comprising said antigen-specific cells, f) co-cultivation of the cells of step e), g) flow cytometry analysis of the B cells with regard to their cell number and CD83 expression, thereby determining the potency of said antigen-specific cells in said sample.

Abstract: The invention relates to a chromatographic process for substance separation in the context of the preparation of chemicals such as, for example, chiral pharmaceuticals, isomers or biomolecules on the small-scale and production scale, based on Simulated Moving Bed (SMB=countercurrent chromatography) technology.

Abstract: To produce at least two bonded-together layers (11, 13; 11?, 13), it is proposed that the material of at least one of the layers (13) is melted and subsequently, by spray compacting with a spray cone (10, 10?), is applied to the other layer, which is moved in relation to the spray cone (10, 10?), in such a way that the material composite is thereby produced.

Abstract: To produce at least two bonded-together layers (11, 13; 11?, 13), it is proposed that the material of at least one of the layers (13) is melted and subsequently, by spray compacting with a spray cone (10, 10?), is applied to the other layer, which is moved in relation to the spray cone (10, 10?), in such a way that the material composite is thereby produced.

Abstract: The invention relates to a chromatographic process for substance separation in the context of the preparation of chemicals such as, for example, chiral pharmaceuticals, isomers or biomolecules on the small-scale and production scale, based on Simulated Moving Bed (SMB=countercurrent chromatography) technology.

Abstract: The invention relates to a chromatographic process for substance separation in the context of the preparation of chemicals such as, for example, chiral pharmaceuticals, isomers or biomolecules on the small-scale and production scale, based on Simulated Moving Bed (SMB=countercurrent chromatography) technology.

Abstract: A runner for a suspended ceiling grid is roll-formed from a single strip of sheet metal so as to have a generally symmetrical appearance about a vertical center line, with a double vertical web and a double-thickness flange for supporting ceiling tiles.

Abstract: A suspended ceiling grid beam is provided that has an increased beam height to provide enhanced resistance to downward deflection. The beam has a cross-section generally in the form of an inverted T, with a central web, a pair of panel support flanges extending from one edge of the web, and a reinforcing bulb extending from the other edge of the web. The reinforcing bulb has a generally planar, fin-like structure extending therefrom opposite to and generally co-planar with the central web.

Abstract: A grid system is provided that is particularly suited for the suspended ceiling system that varies in the vertical plane. An elongated carrier tube is provided the spans substantially the width of the grid system that has a slot therein adapted to receive the strengthening bulb of a main runner. A clip is provided that seats on the carrier tube that has opposed faces for capturing the bulb of the runner, so as to secure the runner to the tube carrier.

Abstract: A perimeter clip is made of a single piece of sheet metal and includes first and second legs that are bent at approximately 90 degrees with respect to each other. The first leg is for engaging the vertical leg of a wall angle. The second leg is adapted to receive the head or bulb of the runner. The first leg includes an upper portion and a lower portion. The upper portion of the first leg forms a back plate that is displaced from the plane of the lower portion, with a generally horizontal ledge connecting the upper portion to the lower portion. The first leg has a tongue or tab that is displaced from the plane of the remainder of the lower portion so that, when in place, the vertical leg of the wall angle is held between the tongue and the remainder of the lower portion. The upper portion of the second leg comprises an inverted, generally U-shaped member, the open end of which forms a trough that supports the lower surface of the bulb of the runner.

Abstract: A turbulence generator useful for mixing or as a heat exchanger, comprising a housing having an interior surface defined by an interior wall or walls, and an exterior surface, with at least two turbulence elements, each having at least one non-structured section (3) and at least one structured section (4), comprised of a plurality of alternating ribs (8) and gaps (9), removably inserted therein.

Abstract: The invention describes a device for determining the gas content of a liquid. The device has at least a housing, a measuring chamber base with a cavity and a measuring chamber cover inside the housing. The measuring chamber base and the measuring chamber cover are each movable by a respective piston independently of one another along the longitudinal axis of the housing. The measuring chamber base and the measuring chamber cover form a measuring chamber in the housing. The measuring chamber base or the measuring chamber cover is connected to a pressure sensor and the housing has a liquid inlet and a liquid outlet.

Abstract: High performance thermal control duct for heat exchangers, comprising two sheets, each of which have surface depressions, sandwiched together on both sides of a holed sheet.

Abstract: Diaphragm pump with a multipart pump body, comprising at least three rigid plates and at least two elastic diaphragms arranged between said plates, the plates forming at least one pumping chamber and at least two shut-off chambers, and the pumping chamber and shut-off chambers forming, together with an inlet duct, connecting ducts and an outlet duct, a passage duct; the pumping chamber and the shut-off chambers being separated by the diaphragms in each case into a product space and a control space with an axially movable disc, with an extended rod attached on one side, inserted into said control space, so that the rod, attached on one side of the movable disc, projects outside the metering head and can be adjusted outside the pump to move the movable disc axially and reduce or increase the maximum possible diaphragm travel in the pumping chamber.

Abstract: Diaphragm pump with a multipart pump body, comprising at least three rigid plates and at least two elastic diaphragms arranged between said plates , the plates forming at least one pumping chamber and at least two shut-off chambers, and the pumping chamber and shut-off chambers forming, together with an inlet duct connecting ducts and an outlet duct, a passage duct; the pumping chamber and the shut-off chambers being separated by the diaphragms in each case into a product space and a control space with an axially movable disc, with an extended rod attached on one side, inserted into said control space, so that the rod, attached on one side of the movable disc, projects outside the metering head and can be adjusted outside the pump to move the movable disc axially and reduce or increase the maximum possible diaphragm travel in the pumping chamber.

Abstract: A combination static mixer and heat exchanger having heat exchanger tubes (1) which are provided over their circumference with fins (2a, 2b) which have a static mixing effect.

Abstract: Apparatus for maintaining a predefined pressure in one or more reactors to which pressures from 1 to 500 bar can be applied, with simultaneous measurement of the gas mass flow, comprising at least one buffer container (A) which is equipped with a pressure gauge (B) and can be filled with gas via at least one valve (C), and the buffer container (A) being connected to at least one reactor (F) which is likewise equipped with a pressure gauge (B′), characterized in that the connection between buffer container and reactor contains a restrictor (D) and a valve (E) which is controlled via a control unit (H) which is connected to the pressure gauges of the reactor (F) and of the buffer container (A) via control lines.

Abstract: A diaphragm pump with a multi-part pump body is described. The pump consists at least of three rigid plates (201, 203, 205) and at least two elastic diaphragms (204, 202) arranged between these plates (201, 203, 205), the plates (201, 203, 205) forming, in particular, a pumping chamber (211) and at least two shut-off chambers (210, 212), in each case with an inlet (240) and an outlet (241) orifice for the conveyable material, and the pumping chambers (211) and shut-off chambers (210, 212) forming, together with an inlet duct (207), the connecting ducts (208) and (209) and an outlet duct (206), a passage duct, the pumping chamber (211) and the shut-off chambers (210, 212) being separated by the diaphragms (204, 202) in each case into a product space (230, 231, 232) and a control space (220, 221, 222), and the control spaces (220, 221, 222) having control lines (119, 120, 121) which are connected to a control unit (100, 115).

Abstract: The invention relates to a process for continuously conveying shear-sensitive fluids, in particular polymer latices or plastics dispersions, which is accompanied by the taking of samples and the processing and analysis thereof, to a device for implementing the process and to a new double-long-stroke reciprocating pump.