Abstract: The present invention relates to the use of HTRA1 mRNA antagonists in the treatment of eye disorders, such as macular degeneration, and the use of an HTRA1 levels in the aqueous and vitreous humor as a diagnostic biomarker for the suitability of treatment of a subject with an HTRA1 mRNA antagonist.

Abstract: A method for identifying material in a voxel comprises reading in first and second signal trains, each representing magnetization values determined after exposing the material to predefined radio-frequency pulses. The radio-frequency pulses differ before or during measuring the first signal train in at least one parameter from the radio-frequency pulses before or during measuring the second signal train. The method comprises performing a time-domain-frequency-domain transformation (ILFT) to obtain first and second transformation values. The first transformation value represents a frequency domain signal resulting from the time-domain-frequency-domain transformation on the basis of at least the first signal train. The second transformation value represents a frequency domain signal resulting from the time-domain-frequency-domain transformation on the basis of at least the second signal train.

Abstract: A method and appertaining device is provided for magnetic resonance imaging of a contiguous region of a subject under application of the partially parallel acquisition via modulation of the spin magnetization by way of radio-frequency pulses, as well as via spatial coding of the subject region and via subsequent measurement in cycles of the radio-frequency response signals showing the excited spins. Based on the measurement of the radio-frequency response signals by a coil array comprising two or more radio-frequency receiver coils via which both the coil sensitivity information and the radio-frequency response signals are acquired, each radio-frequency receiver coil acquires a reduce data set for implementation of the image reconstruction and additional modulations of the spin magnetization are used; additional modulations are comprised of modulations of radio-frequency pulses and/or additional modulation of gradients used for spatial coding of the subject regions.

Abstract: A method and appertaining device is provided for magnetic resonance imaging of a contiguous region of a subject under application of the partially parallel acquisition via modulation of the spin magnetization by way of radio-frequency pulses, as well as via spatial coding of the subject region and via subsequent measurement in cycles of the radio-frequency response signals showing the excited spins. Based on the measurement of the radio-frequency response signals by a coil array comprising two or more radio-frequency receiver coils via which both the coil sensitivity information and the radio-frequency response signals are acquired, each radio-frequency receiver coil acquires a reduce data set for implementation of the image reconstruction and additional modulations of the spin magnetization are used; additional modulations are comprised of modulations of radio-frequency pulses and/or additional modulation of gradients used for spatial coding of the subject regions.

Abstract: Methods are disclosed for the production and purification of hydrophobic fusion proteins production and purification of said hydrophobic polypeptides, proteins or peptides. Homogeneous monomeric .beta.-amyloid peptide and tests for screening amyloid toxicity-inhibiting drugs using this monomeric .beta.-amyloid peptide relate to these fusion proteins.

Abstract: A commutator for an electric machine with reciprocally insulated metal segments is described. At least one groove is made in the segments in the circumferential direction of the commutator and receives an insert formed from a precious metal or electrographite part. The axial width of the inserts only takes up part of the commutator contact surface. Alternatively two inserts are juxtaposed in each segment.