Patents by Inventor Peter Jeffery Leedman

Peter Jeffery Leedman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cancer therapy using miRNAs
    Patent number: 9795626
    Abstract: The present invention relates generally to methods and compositions for the treatment of cancers expressing the type 1 insulin-like growth factor receptor (IGF1R) or a constituent of an IGF1R signaling pathway, in particular melanoma, using the microRNA miR-7-5p. Also provided are methods for increasing the sensitivity of such cancers to therapeutic agents.
    Type: Grant
    Filed: October 18, 2013
    Date of Patent: October 24, 2017
    Assignee: The University of Western Australia
    Inventors: Peter Jeffery Leedman, Keith Michael Giles, Rikki Ann Mary Brown
  • CANCER THERAPY USING miRNAs
    Publication number: 20150366895
    Abstract: The present invention relates generally to methods and compositions for the treatment of cancers expressing the type 1 insulin-like growth factor receptor (IGF1R) or a constituent of an IGF1R signaling pathway, in particular melanoma, using the microRNA miR-7-5p. Also provided are methods for increasing the sensitivity of such cancers to therapeutic agents.
    Type: Application
    Filed: October 18, 2013
    Publication date: December 24, 2015
    Inventors: Peter Jeffery LEEDMAN, Keith Michael GILES, Ann Mary BROWN
  • Methods and compositions for increasing sensitivity to tyrosine kinase inhibitors
    Patent number: 9051551
    Abstract: The present invention relates to a method for sensitizing a disease cell expressing the epidermal growth factor receptor (EGFR) to a tyrosine kinase inhibitor selective or specific for EGFR and/or its signalling pathway, the method comprising contacting the cell with a miR-7 miRNA, a precursor or variant thereof, or a miRNA comprising a seed region comprising the sequence GGAAGA.
    Type: Grant
    Filed: November 24, 2010
    Date of Patent: June 9, 2015
    Assignee: The University of Western Australia
    Inventors: Peter Jeffery Leedman, Keith Michael Giles, Felicity Caris Kalinowski
  • METHODS AND COMPOSITIONS FOR INCREASING SENSITIVITY TO TYROSINE KINASE INHIBITORS
    Publication number: 20130116299
    Abstract: The present invention relates to a method for sensitizing a disease cell expressing the epidermal growth factor receptor (EGFR) to a tyrosine kinase inhibitor selective or specific for EGFR and/or its signalling pathway, the method comprising contacting the cell with a miR-7 miRNA, a precursor or variant thereof, or a miRNA comprising a seed region comprising the sequence GGAAGA.
    Type: Application
    Filed: November 24, 2010
    Publication date: May 9, 2013
    Inventors: Peter Jeffery Leedman, Keith Michael Giles, Felicity Caris Kalinowski
  • MODULATION OF EPIDERMAL GROWTH FACTOR RECEPTOR LIGANDS
    Publication number: 20130090366
    Abstract: The present invention relates to a method for modulating the expression and/or activity of an epidermal growth factor receptor (EGFR) ligand in a cell or tissue, the method comprising contacting the cell or tissue with a miR-7 miRNA, a pre-cursor or variant thereof, a miRNA comprising a seed region comprising the sequence GGAAGA, or an antagonist of any such miRNA.
    Type: Application
    Filed: November 24, 2010
    Publication date: April 11, 2013
    Inventors: Peter Jeffery Leedman, Keith Michael Giles, Felicity Caris Kalinowski