Patents by Inventor Peter Jeffrey DANDLIKER

Peter Jeffrey DANDLIKER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF IDENTIFYING A CONDENSATE PHENOTYPE AND USES THEREOF
    Publication number: 20240145034
    Abstract: The present application provides, in some aspects, methods of identifying a condensate of interest associated with a el disease. Also provided are methods of identifying a marker for identifying a condensate of interest associated with a disease. In other aspects, provided herein are methods of identifying a therapeutic agent useful for treating a disease via the identified condensate of interest.
    Type: Application
    Filed: March 1, 2022
    Publication date: May 2, 2024
    Inventors: William W. CHEN, John C. MANTEIGA, Violeta YU, Ann D. KWONG, Peter Jeffrey DANDLIKER, Bruce Aaron BEUTEL, Chi ZHANG, Lingyao ZENG, Andreas STEFFEN, Daniel Franz FREITAG
  • METHODS OF IDENTIFYING INTERACTIONS OF A COMPOUND AND A CONDENSATE, OR A COMPONENT THEREOF, AND USES THEREOF
    Publication number: 20230314443
    Abstract: In some aspects, provided herein are methods of identifying interactions of a compound and a condensate, or a component thereof, and uses thereof. In other aspects, provided herein are methods of identifying (or screening for or designing) compounds, or portions thereof, having a desired interaction with a condensate, or a component thereof. In yet other aspects, provided herein are applications of the methods described herein, e.g., libraries of compounds having known or predicted characteristics, and methods of identifying compounds useful for treatment of a disease.
    Type: Application
    Filed: August 11, 2021
    Publication date: October 5, 2023
    Inventors: Diana Maria MITREA, Matthäus MITTASCH, Peter Jeffrey DANDLIKER, Bruce Aaron BEUTEL, Edgar Erik BOCZEK
  • METHODS OF CHARACTERIZING CONDENSATE-ASSOCIATED CHARACTERISTICS OF COMPOUNDS AND USES THEREOF
    Publication number: 20230176067
    Abstract: Methods of assessing, such as characterizing or determining, condensate-associated characteristics of a compound, such as a test compound, and applications thereof are provided. For example, methods of determining a partition characteristic of a test compound in a target condensate, methods of determining a relative partition characteristic of a test compound in a target condensate, and methods of determining a condensate preference profile of a test compound are provided. Additionally, methods of designing and/or identifying and/or making a compound, or portion thereof, with a desired relative condensate partition characteristic are provided.
    Type: Application
    Filed: October 5, 2022
    Publication date: June 8, 2023
    Inventors: Bruce Aaron BEUTEL, Peter Jeffrey DANDLIKER, Stephen Paul HALE, Mark Andrew MURCKO, Edgar Erik BOCZEK, Matthäus MITTASCH, Diana Maria MITREA
  • COMPOSITIONS, SYSTEMS, AND METHODS FOR IDENTIFYING A COMPOUND THAT MODULATES ONE OR MORE CHARACTERISTICS ASSOCIATED WITH A RBM20 CONDENSATE AND/OR A RBM20 POLYPEPTIDE
    Publication number: 20220365070
    Abstract: The present disclosure, in some aspects, is directed to methods for screening and identifying compounds that modulate one or more characteristics associated with a condensate comprising a RBM20 polypeptide and/or the RBM20 polypeptide. In other aspects, the disclosure is directed to systems and composition components thereof, such as cellular models useful for the methods described herein.
    Type: Application
    Filed: September 17, 2020
    Publication date: November 17, 2022
    Inventors: Avinash PATEL, Mark Andrew MURCKO, Stephen Paul HALE, Bruce Aaron BEUTEL, Bozena KESIC, Juwina WIJAYA, John C. MANTEIGA, Peter Jeffrey DANDLIKER, Ann D. KWONG
  • Methods of characterizing condensate-associated characteristics of compounds and uses thereof
    Patent number: 11493519
    Abstract: Methods of assessing, such as characterizing or determining, condensate-associated characteristics of a compound, such as a test compound, and applications thereof are provided. For example, methods of determining a partition characteristic of a test compound in a target condensate, methods of determining a relative partition characteristic of a test compound in a target condensate, and methods of determining a condensate preference profile of a test compound are provided. Additionally, methods of designing and/or identifying and/or making a compound, or portion thereof, with a desired relative condensate partition characteristic are provided.
    Type: Grant
    Filed: February 7, 2020
    Date of Patent: November 8, 2022
    Assignee: DEWPOINT THERAPEUTICS, INC.
    Inventors: Bruce Aaron Beutel, Peter Jeffrey Dandliker, Stephen Paul Hale, Mark Andrew Murcko, Edgar Erik Boczek, Matthäus Mittasch, Diana Maria Mitrea
  • METHODS OF CHARACTERIZING CONDENSATE-ASSOCIATED CHARACTERISTICS OF COMPOUNDS AND USES THEREOF
    Publication number: 20200284801
    Abstract: Methods of assessing, such as characterizing or determining, condensate-associated characteristics of a compound, such as a test compound, and applications thereof are provided. For example, methods of determining a partition characteristic of a test compound in a target condensate, methods of determining a relative partition characteristic of a test compound in a target condensate, and methods of determining a condensate preference profile of a test compound are provided. Additionally, methods of designing and/or identifying and/or making a compound, or portion thereof, with a desired relative condensate partition characteristic are provided.
    Type: Application
    Filed: February 7, 2020
    Publication date: September 10, 2020
    Inventors: Bruce Aaron BEUTEL, Peter Jeffrey DANDLIKER, Stephen Paul HALE, Mark Andrew MURCKO, Edgar Erik BOCZEK, Matthäus MITTASCH, Diana Maria MITREA