Patents by Inventor Peter John Bonitatibus, Jr.
Peter John Bonitatibus, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 8252317Abstract: The present invention provides novel metal alginates prepared from non-cross-linked alginate monomers such as sodium alginate and an aqueous solution of a group 4, 5, or 6 metal oxyhalide. The novel group 4, 5, and 6 metal alginates are useful in the preparation of cell culture supports, exhibit useful X-ray contrast properties, and exhibit unanticipated stability to standard autoclave conditions relative to known metal alginates such as calcium alginate. In general, the novel metal alginates provided by the present invention offer features and properties not observed in known metal alginates such as calcium or barium alginates.Type: GrantFiled: February 26, 2009Date of Patent: August 28, 2012Assignee: General Electric CompanyInventors: Andrew Soliz Torres, Peter John Bonitatibus, Jr.
-
Patent number: 8246932Abstract: Composition of non-radioactive traceable metal isotope-enriched nanoparticles, and methods of their use for determining in-vivo biodistribution are provided. The methods comprise the steps of: (a) introducing the nanoparticles into the biological material, wherein the nanoparticles comprise at least one inorganic core, and the inorganic core comprises at least two metal isotopes in a predetermined ratio; wherein at least one metal isotope is enriched non-radioactive traceable metal isotope and (b) determining the distribution of the nanoparticles in the biological material based on the predetermined ratio of the metal isotopes.Type: GrantFiled: March 28, 2008Date of Patent: August 21, 2012Assignee: General Electric CompanyInventors: Peter John Bonitatibus, Jr., Amit Mohan Kulkarni, Andrew Soliz Torres, Ying Zhou, Chiaki Treynor, Daniel Eugene Meyer
-
Publication number: 20120176016Abstract: A core-shell particulate is provided. The core-shell particulate includes a metal core particulate including a noble metal or a refractory metal; and a ceramic shell including a transition metal composition. The transition metal composition includes a material including hafnium, or zirconium, or yttrium, or tantalum, or tungsten, or molybdenum, or niobium, or any combinations thereof. The ceramic shell substantially uniformly encloses the metal core particulate. A method of making a core-shell particulate is provided. The method includes the steps of providing a metal core particulate; and disposing a ceramic shell including a transition metal composition onto the core particulate. An article including a plurality of core-shell particulates is also provided.Type: ApplicationFiled: September 28, 2007Publication date: July 12, 2012Applicant: General Electric CompanyInventors: Peter John Bonitatibus, JR., Vikas Midha
-
Publication number: 20100278734Abstract: Compositions of nanoparticles functionalized with at least one net positively charged group and at least one net negatively charged group, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core and a shell. The shell comprises a plurality of silane moieties; at least one silane moiety of the plurality is functionalized with a net positively charged group and at least one silane moiety of the plurality is functionalized with a net negatively charged group.Type: ApplicationFiled: April 29, 2009Publication date: November 4, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Peter John Bonitatibus, JR., Matthew David Butts, Robert Edgar Colborn, Amit Mohan Kulkarni, Bruce Allan Hay, Andrew Soliz Torres, Brian Christopher Bales, Michael Ernest Marino
-
Publication number: 20100278749Abstract: Compositions of nanoparticles functionalized with at least one net positively charged group and at least one net negatively charged group, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core and a shell. The shell comprises a plurality of silane moieties; at least one silane moiety of the plurality is functionalized with a net positively charged group and at least one silane moiety of the plurality is functionalized with a net negatively charged group.Type: ApplicationFiled: April 29, 2009Publication date: November 4, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Peter John Bonitatibus, JR., Matthew David Butts, Robert Edgar Colborn, Amit Mohan Kulkarni, Bruce Allan Hay, Andrew Soliz Torres, Brian Christopher Bales, Michael Ernest Marino
-
Publication number: 20100278748Abstract: Compositions of nanoparticles functionalized with at least one net positively charged group and at least one net negatively charged group, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core and a shell. The shell comprises a plurality of silane moieties; at least one silane moiety of the plurality is functionalized with a net positively charged group and at least one silane moiety of the plurality is functionalized with a net negatively charged group.Type: ApplicationFiled: April 29, 2009Publication date: November 4, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Peter John Bonitatibus, JR., Matthew David Butts, Robert Edgar Colborn, Amit Mohan Kulkarni, Bruce Allan Hay, Andrew Soliz Torres, Brian Christopher Bales, Michael Ernest Marino
-
Publication number: 20100216243Abstract: The present invention provides novel metal alginates prepared from non-cross-linked alginate monomers such as sodium alginate and an aqueous solution of a group 4, 5, or 6 metal oxyhalide. The novel group 4, 5, and 6 metal alginates are useful in the preparation of cell culture supports, exhibit useful X-ray contrast properties, and exhibit unanticipated stability to standard autoclave conditions relative to known metal alginates such as calcium alginate. In general, the novel metal alginates provided by the present invention offer features and properties not observed in known metal alginates such as calcium or barium alginates.Type: ApplicationFiled: February 26, 2009Publication date: August 26, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Andrew Soliz Torres, Peter John Bonitatibus, JR.
-
Publication number: 20100166664Abstract: Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.Type: ApplicationFiled: December 29, 2008Publication date: July 1, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Matthew David Butts, Robert Edgar Colborn, Peter John Bonitatibus, JR., Amit Mohan Kulkarni, Bruce Allan Hay, Andrew Soliz Torres, Brian Christopher Bales, Michael Ernest Marino
-
Publication number: 20100166665Abstract: Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.Type: ApplicationFiled: December 29, 2008Publication date: July 1, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Matthew David Butts, Robert Edgar Colborn, Peter John Bonitatibus, JR., Amit Mohan Kulkarni, Bruce Allan Hay, Andrew Soliz Torres, Brian Christopher Bales, Michael Ernest Marino
-
Publication number: 20100166666Abstract: Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.Type: ApplicationFiled: December 29, 2008Publication date: July 1, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Matthew David Butts, Robert Edgar Colborn, Peter John Bonitatibus, JR., Amit Mohan Kulkarni, Bruce Allan Hay, Andrew Soliz Torres, Brian Christopher Bales, Michacl Ernest Marino
-
Publication number: 20090246143Abstract: Composition of non-radioactive traceable metal isotope-enriched nanoparticles, and methods of their use for determining in-vivo biodistribution are provided. The methods comprise the steps of: (a) introducing the nanoparticles into the biological material, wherein the nanoparticles comprise at least one inorganic core, and the inorganic core comprises at least two metal isotopes in a predetermined ratio; wherein at least one metal isotope is enriched non-radioactive traceable metal isotope and (b) determining the distribution of the nanoparticles in the biological material based on the predetermined ratio of the metal isotopes.Type: ApplicationFiled: March 28, 2008Publication date: October 1, 2009Applicant: GENERAL ELECTRIC COMPANYInventors: Peter John Bonitatibus, JR., Amit Mohan Kulkarni, Andrew Soliz Torres, Ying Zhou, Chiaki Treynor, Daniel Eugene Meyer
-
Publication number: 20090087383Abstract: The present invention is generally directed to core/shell nanoparticles, wherein such core/shell nanoparticles comprise a nanoparticle core and a nanoshell disposed about the nanoparticle core such that, in the aggregate, they form a core/shell nanoparticle that is operable for use as an imaging agent in X-ray/computed tomography (CT). Typically, such core/shell nanoparticle-based X-ray CT imaging agents further comprise a targeting species for targeting the imaging agent to diseased sites. Included herein are methods for forming such agents, comprising forming an ensemble of core/shell nanoparticles, wherein the mean diameter of the ensemble of core/shell nanoparticles is selected so as to render the nanoparticles in the ensemble substantially clearable by a mammalian kidney.Type: ApplicationFiled: November 24, 2008Publication date: April 2, 2009Applicant: GENERAL ELECTRIC COMPANYInventors: Peter John Bonitatibus, JR., David Cheney deMoulpied, Andrew Soliz Torres, Amit Mohan Kulkarni, Robert Edgar Colborn, Paul William Buckley