Patents by Inventor Peter John Littrup
Peter John Littrup has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230089236Abstract: A method for characterizing tissue of a patient, including receiving acoustic data derived from the interaction between the tissue and the acoustic waves irradiating the tissue; generating a morphology rendering of the tissue from the acoustic data, in which the rendering represents at least one biomechanical property of the tissue; determining a prognostic parameter for a region of interest in the rendering, in which the prognostic parameter incorporates the biomechanical property; and analyzing the prognostic parameter to characterize the region of interest. In some embodiment, the method further includes introducing a contrast agent into the tissue; generating a set of enhanced morphology renderings of the tissue after introducing the contrast agent; determining an enhanced prognostic parameter from the enhanced morphology renderings; and analyzing the enhanced prognostic parameter.Type: ApplicationFiled: June 28, 2022Publication date: March 23, 2023Applicant: Delphinus Medical Technologies, Inc.Inventors: Nebojsa Duric, Peter John Littrup
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Publication number: 20220257761Abstract: This invention relates to a therapeutic composition comprising i) at least two immune checkpoint inhibitors, ii) at least one drug selected from a cytokine a cytotoxic or cytostatic chemotherapeutic drug, and combinations thereof, and iii) a cancer vaccine prepared from tumor or cancer cells, or derivatives thereof, that have been prepared through an ex vivo treatment that creates necrotic and/or necroptotic cancer cells while minimizing destruction of cancer antigens. This invention also relates to a method of treating a tumor or a cancer in a patient comprising administering to a patient in need thereof the therapeutic composition in an amount effective to treat the tumor or cancer.Type: ApplicationFiled: February 11, 2022Publication date: August 18, 2022Inventors: David Granger Bostwick, Brian Rafferty Bostwick, Peter John Littrup
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Patent number: 11399798Abstract: A method for characterizing tissue of a patient, including receiving acoustic data derived from the interaction between the tissue and the acoustic waves irradiating the tissue; generating a morphology rendering of the tissue from the acoustic data, in which the rendering represents at least one biomechanical property of the tissue; determining a prognostic parameter for a region of interest in the rendering, in which the prognostic parameter incorporates the biomechanical property; and analyzing the prognostic parameter to characterize the region of interest. In some embodiment, the method further includes introducing a contrast agent into the tissue; generating a set of enhanced morphology renderings of the tissue after introducing the contrast agent; determining an enhanced prognostic parameter from the enhanced morphology renderings; and analyzing the enhanced prognostic parameter.Type: GrantFiled: December 12, 2018Date of Patent: August 2, 2022Assignee: Delphinus Medical Technologies, Inc.Inventors: Nebojsa Duric, Peter John Littrup
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Publication number: 20200015775Abstract: A method of characterizing the pathological response of tissue to a treatment plan, including: obtaining a set of sequential morphology renderings of the tissue, wherein each rendering corresponds to a particular point in time during the treatment plan; generating a set of representative values of a biomechanical property of the tissue for the set of renderings, wherein each representative value is based on a corresponding rendering; determining a trend of the biomechanical property based on the set of representative values; and predicting response of the tissue to the treatment plan based on the trend of the biomechanical property.Type: ApplicationFiled: March 28, 2019Publication date: January 16, 2020Inventors: Peter John Littrup, Nebojsa DURIC
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Publication number: 20190150885Abstract: A method for characterizing tissue of a patient, including receiving acoustic data derived from the interaction between the tissue and the acoustic waves irradiating the tissue; generating a morphology rendering of the tissue from the acoustic data, in which the rendering represents at least one biomechanical property of the tissue; determining a prognostic parameter for a region of interest in the rendering, in which the prognostic parameter incorporates the biomechanical property; and analyzing the prognostic parameter to characterize the region of interest. In some embodiment, the method further includes introducing a contrast agent into the tissue; generating a set of enhanced morphology renderings of the tissue after introducing the contrast agent; determining an enhanced prognostic parameter from the enhanced morphology renderings; and analyzing the enhanced prognostic parameter.Type: ApplicationFiled: December 12, 2018Publication date: May 23, 2019Inventors: Nebojsa Duric, Peter John LITTRUP
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Patent number: 10278672Abstract: A method of characterizing the pathological response of tissue to a treatment plan, including: obtaining a set of sequential morphology renderings of the tissue, wherein each rendering corresponds to a particular point in time during the treatment plan; generating a set of representative values of a biomechanical property of the tissue for the set of renderings, wherein each representative value is based on a corresponding rendering; determining a trend of the biomechanical property based on the set of representative values; and predicting response of the tissue to the treatment plan based on the trend of the biomechanical property.Type: GrantFiled: August 25, 2015Date of Patent: May 7, 2019Assignee: Delphinus Medical Technologies, Inc.Inventors: Peter John Littrup, Nebojsa Duric
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Patent number: 10231696Abstract: A method for characterizing tissue of a patient, including receiving acoustic data derived from the interaction between the tissue and the acoustic waves irradiating the tissue; generating a morphology rendering of the tissue from the acoustic data, in which the rendering represents at least one biomechanical property of the tissue; determining a prognostic parameter for a region of interest in the rendering, in which the prognostic parameter incorporates the biomechanical property; and analyzing the prognostic parameter to characterize the region of interest. In some embodiment, the method further includes introducing a contrast agent into the tissue; generating a set of enhanced morphology renderings of the tissue after introducing the contrast agent; determining an enhanced prognostic parameter from the enhanced morphology renderings; and analyzing the enhanced prognostic parameter.Type: GrantFiled: October 12, 2017Date of Patent: March 19, 2019Assignee: Delphinus Medical Technologies, Inc.Inventors: Nebojsa Duric, Peter John Littrup
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Publication number: 20180125447Abstract: A method for characterizing tissue of a patient, including receiving acoustic data derived from the interaction between the tissue and the acoustic waves irradiating the tissue; generating a morphology rendering of the tissue from the acoustic data, in which the rendering represents at least one biomechanical property of the tissue; determining a prognostic parameter for a region of interest in the rendering, in which the prognostic parameter incorporates the biomechanical property; and analyzing the prognostic parameter to characterize the region of interest. In some embodiment, the method further includes introducing a contrast agent into the tissue; generating a set of enhanced morphology renderings of the tissue after introducing the contrast agent; determining an enhanced prognostic parameter from the enhanced morphology renderings; and analyzing the enhanced prognostic parameter.Type: ApplicationFiled: October 12, 2017Publication date: May 10, 2018Inventors: Nebojsa Duric, Peter John Littrup
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Patent number: 9814441Abstract: A method for characterizing tissue of a patient, including receiving acoustic data derived from the interaction between the tissue and the acoustic waves irradiating the tissue; generating a morphology rendering of the tissue from the acoustic data, in which the rendering represents at least one biomechanical property of the tissue; determining a prognostic parameter for a region of interest in the rendering, in which the prognostic parameter incorporates the biomechanical property; and analyzing the prognostic parameter to characterize the region of interest. In some embodiment, the method further includes introducing a contrast agent into the tissue; generating a set of enhanced morphology renderings of the tissue after introducing the contrast agent; determining an enhanced prognostic parameter from the enhanced morphology renderings; and analyzing the enhanced prognostic parameter.Type: GrantFiled: June 30, 2015Date of Patent: November 14, 2017Assignee: DELPHINUS MEDICAL TECHNOLOGIES, INC.Inventors: Nebojsa Duric, Peter John Littrup
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Publication number: 20150359508Abstract: A method of characterizing the pathological response of tissue to a treatment plan, including: obtaining a set of sequential morphology renderings of the tissue, wherein each rendering corresponds to a particular point in time during the treatment plan; generating a set of representative values of a biomechanical property of the tissue for the set of renderings, wherein each representative value is based on a corresponding rendering; determining a trend of the biomechanical property based on the set of representative values; and predicting response of the tissue to the treatment plan based on the trend of the biomechanical property.Type: ApplicationFiled: August 25, 2015Publication date: December 17, 2015Inventors: Peter John Littrup, Nebojsa Duric
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Publication number: 20150297174Abstract: A method for characterizing tissue of a patient, including receiving acoustic data derived from the interaction between the tissue and the acoustic waves irradiating the tissue; generating a morphology rendering of the tissue from the acoustic data, in which the rendering represents at least one biomechanical property of the tissue; determining a prognostic parameter for a region of interest in the rendering, in which the prognostic parameter incorporates the biomechanical property; and analyzing the prognostic parameter to characterize the region of interest. In some embodiment, the method further includes introducing a contrast agent into the tissue; generating a set of enhanced morphology renderings of the tissue after introducing the contrast agent; determining an enhanced prognostic parameter from the enhanced morphology renderings; and analyzing the enhanced prognostic parameter.Type: ApplicationFiled: June 30, 2015Publication date: October 22, 2015Inventors: Nebojsa Duric, Peter John Littrup
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Patent number: 9144403Abstract: A method of characterizing the pathological response of tissue to a treatment plan, including: obtaining a set of sequential morphology renderings of the tissue, wherein each rendering corresponds to a particular point in time during the treatment plan; generating a set of representative values of a biomechanical property of the tissue for the set of renderings, wherein each representative value is based on a corresponding rendering; determining a trend of the biomechanical property based on the set of representative values; and predicting response of the tissue to the treatment plan based on the trend of the biomechanical property.Type: GrantFiled: February 14, 2011Date of Patent: September 29, 2015Assignee: Delphinus Medical Technologies, Inc.Inventors: Nebojsa Duric, Peter John Littrup
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Patent number: 9101290Abstract: A method for characterizing tissue of a patient, including receiving acoustic data derived from the interaction between the tissue and the acoustic waves irradiating the tissue; generating a morphology rendering of the tissue from the acoustic data, in which the rendering represents at least one biomechanical property of the tissue; determining a prognostic parameter for a region of interest in the rendering, in which the prognostic parameter incorporates the biomechanical property; and analyzing the prognostic parameter to characterize the region of interest. In some embodiment, the method further includes introducing a contrast agent into the tissue; generating a set of enhanced morphology renderings of the tissue after introducing the contrast agent; determining an enhanced prognostic parameter from the enhanced morphology renderings; and analyzing the enhanced prognostic parameter.Type: GrantFiled: December 11, 2012Date of Patent: August 11, 2015Assignee: Delphinus Medical Technologies, Inc.Inventors: Nebojsa Duric, Peter John Littrup
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Patent number: 8876716Abstract: A method for characterizing tissue of a patient, including receiving acoustic data derived from the interaction between the tissue and the acoustic waves irradiating the tissue; generating a morphology rendering of the tissue from the acoustic data, in which the rendering represents at least one biomechanical property of the tissue; determining a prognostic parameter for a region of interest in the rendering, in which the prognostic parameter incorporates the biomechanical property; and analyzing the prognostic parameter to characterize the region of interest. In some embodiment, the method further includes introducing a contrast agent into the tissue; generating a set of enhanced morphology renderings of the tissue after introducing the contrast agent; determining an enhanced prognostic parameter from the enhanced morphology renderings; and analyzing the enhanced prognostic parameter.Type: GrantFiled: February 14, 2011Date of Patent: November 4, 2014Assignee: Delphinus Medical Technologies, Inc.Inventors: Nebojsa Duric, Peter John Littrup
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Publication number: 20130303895Abstract: A system and method for performing an image-guided biopsy of a target mass of a volume of tissue comprising: a transducer array comprising a set of ultrasound emitters and a set of ultrasound receivers configured to generate a set of acoustic data based upon acoustic waveforms received from the volume of tissue, wherein the transducer array is configured to enable determination of a location of the target mass based on the set of acoustic data; a base proximate to the transducer array; a fixation plate coupled to the base and cooperating with the base and the transducer array to at least partially define an adjustable receiving space configured to receive the volume of tissue; and a guiding module coupled to the base and comprising an aperture configured to align a biopsy tool with the location of the target mass.Type: ApplicationFiled: May 14, 2013Publication date: November 14, 2013Applicant: Delphinus Medical Technologies, Inc.Inventors: Peter John Littrup, Nebojsa Duric, Gerrit Lee Littrup
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Publication number: 20110201932Abstract: A method for characterizing tissue of a patient, including receiving acoustic data derived from the interaction between the tissue and the acoustic waves irradiating the tissue; generating a morphology rendering of the tissue from the acoustic data, in which the rendering represents at least one biomechanical property of the tissue; determining a prognostic parameter for a region of interest in the rendering, in which the prognostic parameter incorporates the biomechanical property; and analyzing the prognostic parameter to characterize the region of interest. In some embodiment, the method further includes introducing a contrast agent into the tissue; generating a set of enhanced morphology renderings of the tissue after introducing the contrast agent; determining an enhanced prognostic parameter from the enhanced morphology renderings; and analyzing the enhanced prognostic parameter.Type: ApplicationFiled: February 14, 2011Publication date: August 18, 2011Inventors: Nebojsa Duric, Peter John Littrup
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Publication number: 20110201928Abstract: A method of characterizing the pathological response of tissue to a treatment plan, including: obtaining a set of sequential morphology renderings of the tissue, wherein each rendering corresponds to a particular point in time during the treatment plan; generating a set of representative values of a biomechanical property of the tissue for the set of renderings, wherein each representative value is based on a corresponding rendering; determining a trend of the biomechanical property based on the set of representative values; and predicting response of the tissue to the treatment plan based on the trend of the biomechanical property.Type: ApplicationFiled: February 14, 2011Publication date: August 18, 2011Inventors: Nebojsa Duric, Peter John Littrup