Abstract: Disclosed are various embodiments for generating and verifying stateful hash-based signatures. A message hash of a message is generated using a cryptographic hash function. Then, the message hash is split into a predefined number of parts of equal size. Next, a value of a signature debt is calculated for each of the predefined number of parts of the message hash. Subsequently, a respective signature part is calculated for each of the predefined number of parts of the message hash by applying the cryptographic hash function to a respective portion of a private key for a number of times equal to the value of the signature debt. Next, the respective signature parts are concatenated to generate a signature for the message.

Abstract: The present invention provides a clinically applicable method of stem cell transplantation that facilitates engraftment and reconstitutes immunocompetence of the recipient without requiring radiotherapy or chemotherapy, and without development of GVHD or graft rejection. Aspects of the present invention are based on the discovery that the depletion of the endogenous stem cell niche facilitates efficient engraftment of stem cells into that niche. In particular, the present invention combines the use of selective ablation of endogenous stem cells with a combination of antibodies specific for CD117, and agents that modulate immunoregulatory signaling pathways, e.g. agonists of immune costimulatory molecules, in combination with the administration to the recipient of exogenous stem cells, resulting in efficient, long-term engraftment, even in immunocompetent recipients.

Abstract: An irrigation communicates wirelessly with irrigation control valves. A wireless controller transceiver unit obtains signals from the irrigation controller and transmits these signals wirelessly to a valve transceiver. The irrigation control valves open or close according to the signals received by the valve transceiver. The irrigation system also includes an auxiliary communication device that communicates user commands to the controller transceiver. The user commands are used to create associations between the controller transceiver and each of the valve transceivers. The communication link between the auxiliary communication device and the communication transceiver or the valve transceiver can be an RF communication link such as Bluetooth, a close field communication link such as an inductive communication link, or an optical communication link.

Abstract: The invention relates to UBE3A protein targets and their usage as target engagement biomarkers for compounds that modulate ube3a expression.

Abstract: Temperature control device (1) has a hot water inlet (12), a cold water inlet (14) and an outlet (16) for tempered water. A diffuser (18) is provided in the device (1) to disrupt the flow of hot water after it enters the device (1). The disrupted hot water emerges from the diffuser (18) into a chamber (20) in which it is melded with cold water that is able to enter the chamber (20) from the inlet (14) when a piston (22) is spaced from a seat (24). The melded hot and cold water result in tempered water that is discharged from the outlet (16). A temperature sensitive device (26) is provided, which is responsive to changes in ambient temperature. A temperature setting mechanism (52) is provided which is operatively associated with the temperature sensitive device (26) and permits the maximum temperature of the discharged tempered water to be adjusted.

Abstract: The present disclosure provides compounds, compositions containing such compounds, and methods of designing, developing, producing and preparing compounds represented by general Formula (I), including pharmaceutically acceptable salts thereof or a synthetic intermediate thereof: The compounds act as MEK inhibitors and are capable of displaying one or more beneficial therapeutic effects, including treating cancer.

Abstract: The present disclosure generally relates to a method for testing a telecommunication standard-based positioning, navigation, and timing system and a test device. The system includes the test device. Radio signals from at least three different transmitters are received by the test device. Each transmitter transmits a radio signal according to the telecommunication standard. An assessed position of the test device is determined based on the radio signals received by the test device. The position of the mobile device is determined by the test device additionally to the assessed position. The assessed position is compared with the determined position.

Abstract: An x-ray scanning system, and corresponding method, includes an x-ray source that produces incident x-ray radiation having end-point x-ray energy, which, in various embodiments, can be greater than about 200 keV, between about 200 keV and about 500 keV, or greater than about 500 keV. The system also includes a disk chopper wheel that can be irradiated by and attenuate the incident x-ray radiation. The disk chopper wheel further defines one or more slits configured to pass the incident x-ray radiation through the disk chopper wheel for scanning a target. In some embodiments, the high end-point x-ray energies with disk chopper wheels are facilitated by forming the incident x-ray radiation as a collimated fan beam and/or orienting the chopper wheel with a wheel plane substantially non-perpendicular to a fan beam plane, increasing effective thickness of a disk chopper wheel to attenuate incident x-rays of higher energies.

Abstract: An irrigation system comprises an irrigation controller that receives user input and provides a power signal and command and message data to an encoder. The encoder encodes the command and message data onto the power signal to provide a data encoded power waveform that is sent over a two-wire path. The irrigation system further comprises one or more decoders in communication with the two-wire path to receive the data encoded power waveform and one or more irrigation valves in communication with the one or more decoders. The data encoded power waveform provides power to the decoders and the decoders decode the command and message data from the data encoded power waveform to control the irrigation valves according to the user input.

Abstract: A cosmetic composition comprising a ferment from a fermentation mixture comprising at least one prebiotic active ingredient, a structured water component, and at least one probiotic microorganism is disclosed. The ferment may further comprise at least one cosmetic active ingredient. A method of increasing collagen production of the skin by applying the cosmetic composition is also disclosed.

Abstract: A status indicator light assembly for a trailer includes a housing having a mounting member having an interface surface configured to face a portion of the trailer, a support member connected to the mounting member, and at least one opening in the at least one support member. The status indicator light assembly also includes at least one status light accommodated in the at least one opening of the housing and a wiring harness having one end coupled to the at least one status light and another end configured to be coupled to an electrical system of the trailer.

Abstract: This invention relates to a therapeutic composition comprising i) at least two immune checkpoint inhibitors, ii) at least one drug selected from a cytokine a cytotoxic or cytostatic chemotherapeutic drug, and combinations thereof, and iii) a cancer vaccine prepared from tumor or cancer cells, or derivatives thereof, that have been prepared through an ex vivo treatment that creates necrotic and/or necroptotic cancer cells while minimizing destruction of cancer antigens. This invention also relates to a method of treating a tumor or a cancer in a patient comprising administering to a patient in need thereof the therapeutic composition in an amount effective to treat the tumor or cancer.

Abstract: An aircraft seat, including: a seat chassis; a seat assembly comprising a seat pan, a seat back and a leg rest; the seat pan being mounted to the seat chassis by a first pivoting connection defining a seat pan pivot axis about which the seat pan pivots, the location of the seat pan pivot axis being fixed relative to the seat chassis; the leg rest being mounted to said seat pan by a pivoting connection defining a leg rest pivot axis about which the leg rest pivots; at least one seat pan link for controlling pivoting of the seat pan about said seat pan pivot axis; and at least one leg rest link connected to the leg rest and the at least one seat pan link; wherein the at least one seat pan link is coupled to the seat pan in front of the seat pan pivot axis.

Abstract: A sensor package may include a sensor housing unit and a first sensor that may acquire a first set of measurements within a first measurement range. The sensor package may also include a second sensor configured to acquire a second set of measurements within a second measurement range. The first measurement range and the second measurement range may include an overlapping range used to calibrate the first set of measurements, the second set of measurements, or both.

Abstract: An air intake system for an internal combustion engine of a vehicle includes a main housing defining an interior chamber configured to receive an air filter, a cover seated on the main housing to enclose the air filter within the interior chamber, dual intake ducts fluidly coupled to the interior chamber and configured to provide cold intake air directly from a high pressure zone behind a vehicle grille, an air outlet formed in the main housing and configured to receive intake air that has passed through the air filter, and an air intake duct having a first end coupled to the air outlet and a second end configured to couple to a throttle body of the engine. The air intake system is configured to provide a short airflow path directly into the engine rather than through a tortuous path.

Abstract: The present disclosure provides compounds, compositions containing such compounds, and methods of designing, developing, producing and preparing compounds represented by general Formula (III), including pharmaceutically acceptable salts thereof or a synthetic intermediate thereof: The compounds act as MEK inhibitors and are capable of displaying one or more beneficial therapeutic effects, including treating cancer.

Abstract: A linerbolt removal tool, including: a housing; a moil supported for reciprocating movement by the housing; an inertial body located within the housing; a gas charged accumulator extending from the inertial body away from the moil; a piston moveable within the inertial body between a striking position at which the piston strikes the moil and a retracted position, whereby firing the piston from its retracted position to its striking position includes causing pressurized gas within the accumulator to accelerate the piston toward the moil, wherein the piston has a striking end for striking the moil and an opposing rear end; and a piston cap that encloses the rear end of the piston, wherein during firing, the piston and the piston cap initially accelerate together and prior to the piston reaching its striking position the piston cap separates from the piston, whereby the piston cap isolates the piston from the accumulator.

Abstract: Systems and method for determining a topic cohesion measurement between a content item and a hyperlinked landing page are presented. In one embodiment, a plurality of content item signals is generated for the content item and a corresponding plurality of signals are generated for the hyperlinked landing page. An analysis of the corresponding signals is conducted to determine a measurement of topic cohesion, a topic cohesion score, between the content item and the hyperlinked landing page. A cohesion predictor model is trained to generate the predictive topic cohesion score between an input content item and a hyperlinked landing page. Upon a determination that the topic cohesion score is less than a predetermined threshold, remedial actions are taken regarding the hyperlink of the content item. Alternatively, positive actions may be carried out, including promoting the content item to others, associating advertisements with the content item, and the like.

Abstract: A method for generating and providing artificial intelligence assisted surgical guidance includes analyzing video images from surgical procedure and training a neural network to identify at least one of anatomical objects, surgical objects, and tissue manipulation in video images. The method includes receiving, by the neural network, a live feed of video images from the surgery. The method further includes classifying, by the neural network, at least one of anatomical objects, surgical objects, and tissue manipulation in the live feed of video images. The method further includes outputting, in real time, surgical guidance based on algorithms created using the classified at least one of anatomical objects, surgical objects, and tissue manipulations in the live feed of video images.

Abstract: The present disclosure relates to a system and method for adjusting a tool with a plurality of segments for inserting into a cavity of a machine. The method includes determining an initial alignment measurement of at least a portion of the tool; comparing the initial alignment measurement to a target alignment measurement to determine an adjustment amount; and adjusting at least one of the plurality of segments based on the adjustment amount. The tool includes a plurality of segments moveably coupled, where one or more of the plurality of segments comprises a unique dimensional measurement affecting a fit tolerance.